滇丁香中抑制α-葡萄糖苷酶活性成分研究

目的:寻找滇丁香中具有抑制α-葡萄糖苷酶活性的成分.方法:利用体外抑制α-葡萄糖苷酶活性模型进行追踪,采用各种色谱法分离,运用多种谱学技术鉴定结构,并对活性较强的几个单体化合物进行酶抑制动力学研究.结果:滇丁香的醋酸乙酯部分具有较高的活性,从中分离出5个抑制α-葡萄糖苷酶活性的化合物,分别鉴定为:莨菪内酯(1),5-甲氧基-8-羟基香豆素(2),1α,3β,24-三羟基熊果酸(3),熊果酸(4)和齐墩果酸(5),其中化合物4(IC_(50) 3-3 mg·L~(-1)),5(IC_(50)2.88 mg·L~(-1))的活性最好,明显高于阳性对照阿卡波糖(IC_(50) 1081.27 mg·L~(-1)).化合物3为竞争性抑制.结论:化合物1～4为首次报道对α-葡萄糖苷酶有抑制活性.     

滇丁香萜苷类化合物研究

目的：对滇丁香乙醇提取物的正丁醇部位进行研究。方法：色谱技术进行分离,MS,NMR,2D NMR等波谱方法进行结构鉴定。结果：分离得到7个化合物Vogeloside(1),epi-Vogeloside(2),Loganoside(3),Loganin(4),Cincholic acid 28-O-β-D-glucopyranosyl ester(5),Cincholic acid-3-O-β-D-glucopyranoside,28-O-β-D-glucopyranosyl ester(6),Cincholic acid-3-O-β-D-glucopyranoside(7)。结论：化合物1～7为首次从该属植物中分离鉴定。     

A new triterpene from Luculia pinciana Hook

A new triterpene named luculiaoic acid A (1), showing inhibitory activity of a leukaemia cell line, along with eleven known compounds, has been isolated from the ethyl acetate extract of the stems of Luculia pinciana Hook. All the structures were elucidated on the basis of NMR, MS, and IR methods. The activity to inhibit Staphylococcus aureus and Candida albicans of all compounds showed that ursolic acid inhibits the growth of Staphylococcus aureus with an MIC of 0.5 mg ml^-1 and an MBC of 10 mg ml^-1, and scopletin inhibits Candida albicans with an MIC of 1 mg ml^-1 and an MBC of 5 mg ml^-1.     

Note: A new triterpene from Luculia pinciana Hook.

A new triterpene named luculiaoic acid A (1), showing inhibitory activity of a leukaemia cell line, along with eleven known compounds, has been isolated from the ethyl acetate extract of the stems of Luculia pinciana Hook. All the structures were elucidated on the basis of NMR, MS, and IR methods. The activity to inhibit Staphylococcus aureus and Candida albicans of all compounds showed that ursolic acid inhibits the growth of Staphylococcus aureus with an MIC of 0.5?mg?ml^?1 and an MBC of 10?mg?ml^?1, and scopletin inhibits Candida albicans with an MIC of 1?mg?ml^?1 and an MBC of 5?mg?ml^?1.