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ZHU Yi Tian LIU Xin Ji LIU Kai Yong ZHANG Qiang YANG Lin Sheng WEI Rong ZHANG Jing Jing TAO Fang Biao 《Biomedical and environmental sciences : BES》2019,32(5):345-356
Objective To investigate the molecular mechanisms of the adverse effects of exposure to sulfamonomethoxin(SMM) in pregnancy on the neurobehavioral development of male offspring. Methods Pregnant mice were randomly divided into four groups: control‐(normal saline), low‐ [10 mg/(kg.day)], middle‐ [50 mg/(kg.day)], and high‐dose [200 mg/(kg.day)] groups, which received SMM by gavage daily during gestational days 1‐18. We measured the levels of short‐chain fatty acids(SCFAs) in feces from dams and male pups. Furthermore, we analyzed the mR NA and protein levels of genes involved in the mammalian target of rapamycin(m TOR) pathway in the hippocampus of male pups by RT‐PCR or Western blotting. Results Fecal SCFA concentrations were significantly decreased in dams. Moreover, the production of individual fecal SCFAs was unbalanced, with a tendency for an increased level of total fecal SCFAs in male pups on postnatal day(PND) 22 and 56. Furthermore, the phosphatidylinositol 3‐kinase(PI3 k)/protein kinase B(AKT)/mTOR or mT OR/ribosomal protein S6 kinase 1(S6 K1)/4 EBP1 signaling pathway was continuously upregulated until PND 56 in male offspring. In addition, the expression of Sepiapterin Reductase(SPR), a potential target of m TOR, was inhibited. Conclusion In utero exposure to SMM, persistent upregulation of the hippocampal mTOR pathway related to dysfunction of the gut(SCFA)‐brain axis may contribute to cognitive deficits in male offspring. 相似文献
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刘敬霞教授治疗缺血性卒中的学术思想,主要体现在临床中重视整体观念及辨证论治,坚持辨体—辨病—辨证相结合的诊疗思路.指出“虚”是缺血性卒中发生的始动因素,“瘀”“痰”“毒”“风”相互胶结为继发因素,贯穿疾病发展的始终.在治疗中遵循益气活血、祛风涤痰、解毒开窍等治疗原则,在用药中尤重视生黄芪、炙黄芪、炒白术、当归、三七、生地黄、葛根、醋柴胡等.在用药的特点上,用药轻灵与质重并举,旨在升清、降浊共存,重用补虚药,并善用祛风药、对药及藤类药. 相似文献
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Jinmi Kim Woonhyoung Lee Geun-Tae Kim Hyon-Suk Kim Soyoung Ock In-Soo Kim Seri Jeong 《Seminars in arthritis and rheumatism》2019,48(4):728-735
Objective
This study aimed to review and compare the analytical and clinical performance of automated indirect immunofluorescence (AIIF) and manual indirect immunofluorescence (MIIF) as anti-nuclear antibody screening assays for patients with systemic rheumatic diseases (SRDs), such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).Methods
A systematic literature search was performed in the Medline, Embase, Cochrane, Web of Science, and Scopus databases for studies published before August 2017. A bivariate random effects model was used to calculate the summary diagnostic values.Results
Twenty-two studies involving 6913 positive and 1818 negative samples of MIIF, as well as 524 combined SRD, 132 SLE, and 104 SSc patients, and 520 controls were available for meta-analysis. The summary positive concordance (PC) of qualitative result between AIIF and MIIF was 93.7%, whereas PCs of total pattern (68.5%; homogeneous, 52.3%; speckled, 56.5%; nucleolar, 52.7%; centromere, 51.4%; nuclear dot, 11.7%) and titer (77.8%) exhibited significantly lower values. The summary clinical sensitivities of AIIF vs. MIIF were 84.7% vs 78.2% for combined SRDs, 95.5% vs. 93.9% for SLE, and 86.5% vs. 83.7% for SSc, respectively. Meanwhile, the summary specificities of AIIF vs. MIIF were 75.6% vs. 79.6% for combined SRDs, 74.2% vs. 83.3% for SLE, and 74.2% vs. 83.3% for SSc, respectively. Although the differences in sensitivity and specificity between AIIF and MIIF were not significant in most subgroups, the summary specificity of SLE and SSc showed statistically significant changes.Conclusions
Our systematic meta-analysis demonstrates that AIIF is comparable to MIIF in distinguishing between the positive and negative results, and screening SRDs based on clinical sensitivities and standardization. However, improvements in the pattern and titer recognition and clinical specificities are necessary. 相似文献4.
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中医所言肺系疾病,属于现代医学呼吸系统疾病范畴.临床常见呼吸系统疾病包括上呼吸道感染、支气管扩张、慢性阻塞性肺疾病、肺炎等,属中医“感冒”、“肺胀”、“咳嗽”范畴.本文对我省名老中医刘尚义教授配伍运用紫菀、款冬花、百部治疗肺系疾病的经验进行了介绍. 相似文献
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恶性胸腔积液严重影响着患者的生活质量,关于治疗恶性胸腔积液的报道并不少见,但疗效却不理想,而中医药治疗本病却具有一定的优势。刘建秋教授认为恶性胸腔积液为本虚标实,阳虚阴盛,虚实夹杂之证,提出"泻肺行气逐饮,益肺健脾补肾,化痰祛瘀抗癌毒"的治疗原则,从探讨恶性胸腔积液的病因病机入手,通过对刘建秋教授辨证论治要点的阐述和典型案例的分析,详述了刘建秋教授对恶性胸腔积液的诊疗特色。 相似文献
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补中益气汤是"补土派"李东垣"补气升阳,甘温除热"的经典方剂。刘敬霞教授在继承国医大师李振华教授治病重视调补脾胃学术思想的同时,又有所发挥,治病不仅重视中医辨证论治,主张健脾益气,温阳升清,亦不忘重视滋养脾胃之阴,以全面培补脾胃之"后天之本",体现了中医"异病同治"的思想;同时还强调西医的辨病论治,重视参考、借鉴现代医学科研方法与现代药理学研究成果,西为中用,中西并用。临证运用补中益气汤化裁治疗多种疑难杂病。 相似文献
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