全文获取类型
收费全文 | 23164篇 |
免费 | 3070篇 |
国内免费 | 398篇 |
专业分类
耳鼻咽喉 | 162篇 |
儿科学 | 404篇 |
妇产科学 | 187篇 |
基础医学 | 2489篇 |
口腔科学 | 6202篇 |
临床医学 | 2507篇 |
内科学 | 1779篇 |
皮肤病学 | 109篇 |
神经病学 | 1333篇 |
特种医学 | 470篇 |
外国民族医学 | 1篇 |
外科学 | 1277篇 |
综合类 | 3516篇 |
现状与发展 | 1篇 |
预防医学 | 3159篇 |
眼科学 | 136篇 |
药学 | 1762篇 |
12篇 | |
中国医学 | 725篇 |
肿瘤学 | 401篇 |
出版年
2024年 | 37篇 |
2023年 | 665篇 |
2022年 | 779篇 |
2021年 | 1033篇 |
2020年 | 995篇 |
2019年 | 711篇 |
2018年 | 869篇 |
2017年 | 637篇 |
2016年 | 1160篇 |
2015年 | 1407篇 |
2014年 | 1820篇 |
2013年 | 1683篇 |
2012年 | 1503篇 |
2011年 | 1322篇 |
2010年 | 1137篇 |
2009年 | 989篇 |
2008年 | 787篇 |
2007年 | 635篇 |
2006年 | 650篇 |
2005年 | 684篇 |
2004年 | 1113篇 |
2003年 | 681篇 |
2002年 | 343篇 |
2001年 | 286篇 |
2000年 | 187篇 |
1999年 | 187篇 |
1998年 | 273篇 |
1997年 | 338篇 |
1996年 | 358篇 |
1995年 | 311篇 |
1994年 | 428篇 |
1993年 | 281篇 |
1992年 | 341篇 |
1991年 | 325篇 |
1990年 | 276篇 |
1989年 | 215篇 |
1988年 | 220篇 |
1987年 | 105篇 |
1986年 | 158篇 |
1985年 | 125篇 |
1984年 | 109篇 |
1983年 | 74篇 |
1982年 | 112篇 |
1981年 | 86篇 |
1980年 | 50篇 |
1979年 | 37篇 |
1978年 | 34篇 |
1977年 | 28篇 |
1976年 | 17篇 |
1975年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
采用Mimics对心脏进行三维重构,用3-matic进行模型优化以及模型误差分析,对左心室室壁运动做速度分布假设,基于UDF宏文件对左心室室壁运动编写程序,将血液视为非牛顿流体,采用动网格技术研究不同血压对左心室血液流动的影响。模拟发现当左心室收缩时,压力梯度明显,内部压力减小。当左心室舒张时,内部压力逐渐增高。二尖瓣口处的速率先增大后减小。血压升高,左心室内剪切应力持续增大,极易破坏红细胞结构,产生溶血现象,导致心脏功能紊乱。 相似文献
3.
《Saudi Dental Journal》2022,34(7):596-603
ObjectiveStudies have shown that gingival crevices may be a significant route for SARS-CoV-2 entry. However, the role of oral health in the acquisition and severity of COVID-19 is not known.DesignA retrospective analysis was performed using electronic health record data from a large urban academic medical center between 12/1/2019 and 8/24/2020. A total of 387 COVID-19 positive cases were identified and matched 1:1 by age, sex, and race to 387 controls without COVID-19 diagnoses. Demographics, number of missing teeth and alveolar crestal height were determined from radiographs and medical/dental charts. In a subgroup of 107 cases and controls, we also examined the rate of change in alveolar crestal height. A conditional logistic regression model was utilized to assess association between alveolar crestal height and missing teeth with COVID-19 status and with hospitalization status among COVID-19 cases.ResultsIncreased alveolar bone loss, OR = 4.302 (2.510 – 7.376), fewer missing teeth, OR = 0.897 (0.835–0.965) and lack of smoking history distinguished COVID-19 cases from controls. After adjusting for time between examinations, cases with COVID-19 had greater alveolar bone loss compared to controls (0.641 ± 0.613 mm vs 0.260 ± 0.631 mm, p < 0.01.) Among cases with COVID-19, increased number of missing teeth OR = 2.1871 (1.146– 4.174) was significantly associated with hospitalization.ConclusionsAlveolar bone loss and missing teeth are positively associated with the acquisition and severity of COVID-19 disease, respectively. 相似文献
4.
【摘要】目的:分析保乳术后放疗患者钛夹动度,并探讨其与乳腺大小、钛夹位置的相关性。方法:随机选取保乳术后放疗患者15例,每周两次锥形束CT。测量乳腺基底面直径(D)和乳高轴(H),以瘤床质心为原点将临床靶区分4个象限。记录各象限内钛夹在左右、腹背、头脚方向动度(MLR、MAP、MSI)以及其与临床靶区最内、最前、最上的距离(DSLR、DSAP、DSSI)。结果:MLR、MAP、MSI分别为(2.2±3.0)、(-1.1±3.6)、(0.8±4.7) mm;系统误差Σ在左、右、腹、背、头、脚分别为1.7、2.2、2.0、2.4、2.9、3.0 mm,随机误差σ分别为2.4、4.0、3.2、4.0、4.7、4.7 mm;靶区对应外放5.9、8.3、7.2、8.8、10.5、10.9 mm。一象限内,当D×H<99.89 cm2,MAP和D×H强相关(r=0.805),MLR、MAP均和DSLR、DSAP、DSSI强正相关(r=0.94, 0.94, 0.91;0.87, 0.91, 0.92),MSI和DSLR、DSAP强正相关(r=0.91, 0.94);四象限内,当D×H<90.71 cm2,MAP和DSLR,MSI和DSAP均强负相关(r=-0.96;-0.95),MLR和DSLR强正相关(r=0.91)。结论:钛夹动度有各向异性,以SI方向外扩最大,并易受乳腺大小、钛夹位置影响。 相似文献
5.
Mitsuhiro Yamada 《Respiratory investigation》2021,59(3):302-311
Alveoli are the basic structure of the lungs, consisting of various types of parenchymal and bone marrow-derived cells including alveolar macrophages. These various types of cells have several important functions; thus, communication between these cells plays an important role in homeostasis as well as in the pathophysiology of diseases in the lungs. For a better understanding of the pathophysiology of lung diseases, researchers have isolated each type of lung cell to investigate the changes in their gene expressions, including their humoral factor or adhesion molecules, to reveal the intercellular communication among these cells. In particular, investigations during the past decade have focused on extracellular vesicles, which are lipid bilayer delimited vesicles released from a cell that can move among various cells and transfer substances, including microRNAs, mRNAs and proteins, thus, functioning as intercellular messengers. Extracellular vesicles can be classified into three general groups: apoptotic bodies, exosomes, and microparticles. Extracellular vesicles, especially exosomes and microparticles, are attracting increasing attention from pulmonologists as tools for understanding pathogenesis and disease diagnosis. Here, we review studies, including our own, on exosomes and microparticles and their roles in both lung homeostasis and the pathogenesis of lung diseases such as idiopathic pulmonary fibrosis, chronic obstructive lung diseases, and acute respiratory distress syndrome. This review also addresses the roles of extracellular vesicles in COVID-19, the current global public health crisis. 相似文献
6.
Background:Dental pain can have a detrimental effect on quality of life. Symptomatic apical periodontitis is the most common cause of dental pain and arise from an inflamed or necrotic dental pulp. There is growing evidence to support the effectiveness of probiotics in combination with antibiotics on periodontitis. We therefor will conduct this study to evaluate the clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis.Methods:We will systematically search the following databases: PubMed, the Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM), and WanFang database. A grey literature search will be conducted using ZETOC Conference Proceedings and Open Grey. Only randomized controlled trials (RCTs) related to research on probiotics in combination with antibiotics to treatment patients with periodontitis will be included. All sources have to be searched from their inception to October 2020. Two authors will independently select studies, extract study data, and evaluate the quality of the included studies. We will use Review Manager Software (RevMan 5.3) to analyze data.Results:This study will systematically evaluate the clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis.Conclusions:This study will generate evidence for a better clinical decision of patients with periodontitis.Registration number:DOI 10.17605/OSF.IO/QZ6SB (https://osf.io/qz6sb/). 相似文献
7.
针对现有基于心冲击描记图进行心率检测存在的抗干扰性不足问题,提出一种鲁棒的心率检测模型,首先对原始信号中受干扰的片段进行补偿重构,然后将J峰作为特征波形,通过基于J峰频段的滤波与差分增强处理放大特征,并设计改进的峰值提取算法定位心跳点,进而得到心率估计值。实验结果表明,所用模型对于不同情形下的心冲击描记图信号均表现出良好的适应性,逐拍检测平均覆盖率为98.3%,平均准确率为98.4%。心率输出结果与金标准一致性高,误差范围控制在[±]5%以内,且运算实时性好,可以为临床或家庭保健提供良好的心率检测方案。 相似文献
8.
9.
10.
Co-trimoxazole is mainly used as a first-line drug for treatment and prophylaxis against Pneumocystis jiroveci pneumonia. This drug, however, has been reported as the most common causative drug for severe cutaneous adverse reactions (SCARs). This study aimed to extensively elucidate the associations between genetic polymorphisms of HLA class I and genes involved in bioactivation and detoxification of co-trimoxazole on co-trimoxazole-induced SCARS in a large sample size and well-defined Thai SCARs patients. A total of 67 patients with co-trimoxazole-induced SCARs, consisting of 51 SJS/TEN patients and 16 DRESS patients, and 91 co-trimoxazole tolerant controls were enrolled in the study. The results clearly demonstrated that the HLA-B113:01 allele was significantly associated with co-trimoxazole-induced SCARs, especially with DRESS (OR = 8.44, 95% CI = 2.66–26.77, P = 2.94 × 10−4, Pc = 0.0126). Moreover, the HLA-C108:01 allele was significantly associated with co-trimoxazole-induced SJS/TEN in the HIV/AIDS patients with an OR of 8.51 (95% CI = 2.18–33.14, P = 8.60 × 10−4, Pc = 0.0241). None of the genes involved in the bioactivation and detoxification of co-trimoxazole investigated in this study play any major role in the development of all phenotypes of SCARs. 相似文献