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Formulation optimization, in situ intestinal absorption and permeability of psoralen and isopsoralen
Wan-Jin?Sun Peng?Zhang Xiang-Wei?Qu Li-Min?Xu Chun-Bao?Yang Shi-Ping?Gu 《中草药(英文版)》2019,11(3):337-343
Objective
To optimize a self-emulsifying drug delivery system (SEDDS) formulation for psoralen and isopsoralen (PSO and IPSO) isolated from Psoraleae Fructus.
Methods
A D-optimal design was used to investigate the influence of oil percentage, surfactant percentage and cosurfactant percentage on several properties of SEDDS including particle size, polydispersity, equilibrium solubility, in situ intestine absorption rate and intestinal permeability. Furthermore, the desirability function approach was applied to obtain the optimal formulation for the system.
Results
The oil percentage, surfactant percentage and cosurfactant percentage were optimized to be 53.6%, 35.7% and 10.7%, respectively, which means the model is available.
Conclusions
The D-optimal design is valuable to optimize the SEDDS formulation and understand formulation compositions’ functions on SEDDS properties. 相似文献
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