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Pedro Fong Cheng N. Ao Kai I. Tou Ka M. Huang Chi C. Cheong Li R. Meng 《Oncology research》2019,27(2):237-251
The aim of this study was to investigate the inhibition effects of cordycepin and its derivatives on endometrial
cancer cell growth. Cytotoxicity MTT assays, clonogenic assays, and flow cytometry were used to observe
the effects on apoptosis and regulation of the cell cycle of Ishikawa cells under various concentrations of
cordycepin, cisplatin, and combinations of the two. Validated in silico docking simulations were performed
on 31 cordycepin derivatives against adenosine deaminase (ADA) to predict their binding affinities and hence
their potential tendency to be metabolized by ADA. Cordycepin has a significant dose-dependent inhibitory
effect on cell proliferation. The combination of cordycepin and cisplatin produced greater inhibition effects
than did cordycepin alone. Apoptosis investigations confirmed the ability of cordycepin to induce the apoptosis of Ishikawa cells. The in silico results indicate that compound MRS5698 is least metabolized by ADA
and has acceptable drug likeness and safety profiles. This is the first study to confirm the cytotoxic effects of
cordycepin on endometrial cancer cells. This study also identified cordycepin derivatives with promising pharmacological and pharmacokinetic properties for further investigation in the development of new treatments for
endometrial cancer 相似文献
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目的:探讨祛腐生肌膏促进创伤后感染性创面愈合的临床疗效。方法 :2014年1月至2018年6月收治暴力外伤致软组织损伤、皮肤缺损伴创面感染60例患者,其中男32例,女28例;年龄18~65岁,平均41.3岁。其中30例行祛腐生肌膏换药治疗(祛腐生肌膏组),30例行常规生理盐水碘伏换药治疗(对照组)。比较两组患者的创面面积减小率、腐肉脱落天数、新生上皮出现时间、换药28 d痊愈率。结果:祛腐生肌膏组患者使用大剂量祛腐生肌膏后,创面脓液增多,肉芽随之新生,创面边缘出现新生上皮,呈现迅速愈合的现象。祛腐生肌膏组患者各个时相点创面愈合率均高于对照组,祛腐生肌膏组患者的腐肉脱落时间和新生上皮出现时间均早于对照组。祛腐生肌膏组换药28 d的痊愈率高于对照组(P0.05)。所有患者治疗后获随访,时间6~12个月,平均9.4个月,骨与肌腱的外露区域最终得以良好覆盖。两组患者治疗过程中生命体征平稳,无不良反应发生。结论:祛腐生肌膏能促进肉芽组织生长,促进新生皮肤产生,加快创伤后感染性创面的愈合。 相似文献
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Backgroundand Purpose: Using of herbal medicines is common for cancer treatment. The aim of this study was to determine the prevalence, reasons, and predicting factors for the use of herbal medicines by Iranian cancer patients.Materials and methodsWe conducted this cross-sectional study on 315 cancer patients through face-to-face interview in Kerman, Southeast of Iran, 2017.ResultsIn total, 267 (84.1%) patients used at least one herbal medicine during chemotherapy courses, while only 42 (16.1%) patients discussed the use of herbal medicines with physicians. Living in urban regions (OR, 2.56; 95% CI, 1.30–5.05; P<0.0001) and the experience of constipation and diarrhea (OR, 2.11; 95% CI, 1.09–4.05; P = 0.02) were determined as some predicting factors for the use of herbal medicines.ConclusionOur findings indicate that as herbal medicines are common among cancer patients and their use is often overlooked, physicians should pay particular attention to herbal medicines during chemotherapy. 相似文献
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BackgroundBreastfeeding women often use herbal products to increase their milk supply. The aim of this study was to summarize the literature about the role of healthcare providers in advising breastfeeding women about herbal product use.MethodsPubmed, ScienceDirect, Web of Science, and CINAHL databases were searched for articles written in English using the Keywords: “breastfeeding” or “lactation” and “herbal medicine*“, “botanical*“, “dietary supplement*“, “natural product*“, “traditional medicine*” or “complementary medicine*“.ResultsTwenty-two articles were included in this review. A lack of inter-professional communication and guidelines, a lack of provider confidence and knowledge about the evidence for the efficacy and safety of herbal products were identified as causing a ‘gap’ between current practice and expectations of breastfeeding women seeking advice about their use herbal products.ConclusionsStrategic and collaborative efforts between key stakeholders are required to ensure the needs of women who are considering herbal product use while breastfeeding are met. 相似文献
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熏洗(浴)疗法临床应用广泛,但方法各异。基于对熏洗(浴)疗法已有临床应用的数据挖掘与分析,结合临床应用实际和相关现代研究,经相关领域专家多次论证,形成中药熏洗(浴)疗法临床应用技术规范(草案)。该规范(草案)包括适应症、禁忌症、用药前评估、用药前准备、药液制备、熏洗温度、熏洗时间、熏洗频率、熏洗疗程、操作方法、用药后处理及评估、注意事项、常见不良反应及应对措施等,以期规范中药熏洗(浴)疗法的临床应用,提高临床疗效,减少不良反应。 相似文献
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《结合医学学报(英文版)》2020,18(5):450-454
Costochondritis (ChC), especially chronic ChC, typically manifests as spontaneous vague pain in anterior chest area and often occurs in adolescents for unknown reasons; it has prevented many collegiate athletes from participating in physical training and competitions. A 21-year-old female collegiate taekwondo athlete suffering from chronic chest pain was sent by her coaches for diagnosis and treatment. Seated motion palpation was used to identify spontaneous and motion-involved pain areas. Palpation in the supine position was used to initially rule out breast diseases. X-ray, electrocardiogram, and cardiac Doppler ultrasound were used in conjunction with myocardial enzyme testing to rule out lung and cardiovascular diseases. The patient was treated using herbal medicines applied via an external patch. The medicine was comprised of Rhizoma Corydalis and borneol, and the treatment lasted for seven weeks. For five weeks patches were applied at a frequency of two or three times per day, followed by a two-week period of once per day. The patient reported that the pain was relieved after two weeks of external herb use, and the autonomic chest pain had resolved. Re-examination after one month showed that her upper limb range of motion was close to normal, and her psychological burden had almost disappeared. It is possible to seek more active medicinal treatment and more practical external products for young athletes who is suffering chronic ChC that affects the sport training and competitive performances. 相似文献
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Mohammed Al Essa Abdulrahman Alissa Abdalrhman Alanizi Rami Bustami Feras Almogbel Omar Alzuwayed Meshari Abo Moti Nouf Alsadoun Wasmiyah Alshammari Abdulkareem Albekairy Shmeylan Al Harbi Mohammed Alhokail Jawaher Gramish 《Saudi Pharmaceutical Journal》2019,27(1):138-144
Background
Herbal medicine has been widely utilized by pregnant women despite the limited available evidence regarding the safety and efficacy of that practice. The current available studies, from different countries, estimated that the use of herbal medicine during pregnancy range from 7% up to 96%. The aim of this study is to determine the prevalence, attitude, source of information, and reasoning behind the use of herbal medicine among pregnant women in Saudia Arabia.Methods
A cross-sectional study conducted using a convenience sample including pregnant women who visited the obstetric clinics at King Abdulaziz Medical City in Riyadh, Saudi Arabia. A survey was administered in order to evaluate the prevalence and perception toward herbal medicine use among pregnant women in Saudi Arabia.Results
A total of 297 pregnant women completed the survey. The results showed that 56% of the respondents have used some type of herbal medicine during their pregnancy. Olive oil was utilized in 26% of the respondents followed by cumin 20% and garlic 15%. In addition, 37% of the respondents used herbal medicine by their own initiative, while 33% and 12% used herbal medicine based on recommendations from their families and friends, respectively. Furthermore, 19% of the respondents reported a positive attitude toward herbal medicine use during pregnancy. In addition, the percentage of women with positive attitude was marginally higher among respondents with lower educational level.Conclusion
The prevalence of using herbal medicine is considerably high among pregnant women in Saudi Arabia. Unfortunately, the majority of the users relied on informal sources to use herbal medicine during pregnancy. 相似文献10.
目的:观察中药熏蒸联合推拿和针灸治疗中风的临床疗效。方法:选取2018年11月至2020年7月南通大学第二附属医院收治的中风患者100例作为研究对象,按照入院顺序进行编号,按编号单双数不同分为对照组和观察组,每组50例。对照组给予推拿+针灸治疗,观察组则在对照组基础上给予中药熏蒸治疗。比较2组患者临床疗效、红细胞压积(HCT)、纤维蛋白原(FBG)、血浆黏度(CP)、免疫学(lgA,lgG,lgM)、神经缺损(NDF)、运动功能(FMA)、临床痉挛指数(CSI)及不良反应。结果:治疗后,观察组临床有效率为96.00%,对照组为84.00%,差异有统计学意义(P<0.05);2组FBG、CP、HCT、IgA、IgM、IgG水平均显著降低,且观察组显著低于对照组(P<0.05);2组NDF、CSI评分均明显降低,且观察组明显低于对照组(P<0.05);2组FMA评分上升,且观察组显著高于对照组(P<0.05);对照组与观察组的不良反应发生率分别为10.00%和12.00%,差异无统计学意义(P>0.05)。结论:改良中药熏蒸法联合推拿、针灸可改善中风患者血循环状态和免疫调节,促进神经及运动功能恢复,疗效确切。 相似文献