液质联用技术联合网络药理学探讨白鲜皮治疗湿疹的作用机制＊

目的 采用液质联用技术分析白鲜皮中的主要化学成分；基于网络药理学技术研究白鲜皮治疗皮肤湿疹的活性成分、作用靶点及作用机制。方法 利用液质联用技术（LC-MS）对白鲜皮主要成分进行分析，通过质谱数据结合文献资料，对各主要成分进行快速识别；通过利用SwissADME数据库对白鲜皮潜在活性成分进行预测，筛选主要作用靶点。进行KEGG通路富集分析，最终得到白鲜皮成分-靶点-疾病-通路网络图。采用分子对接技术对主要成分和作用靶点进行验证。结果 从白鲜皮中共分析鉴定了12种成分，进一步筛选得到4种潜在活性成分，可作用于48个关键靶点和14条主要通路。结论 采用LC-MS技术结合网络药理学方法，可以快速分析白鲜皮的潜在活性成分，并初步揭示了成分-靶点-通路之间的关系。通过分子对接技术可以做作用靶点进行验证。     

Allergen avoidance in the secondary and tertiary prevention of allergic diseases: does it work?

Although allergen avoidance is widely recommended as part of a secondary and tertiary prevention strategy for allergic diseases, a clear-cut demonstration of its effectiveness is still lacking. Ongoing observational secondary prevention cohorts show that sensitisation to mite can be prevented in the short term by allergen avoidance measures, but further follow-up of these children is needed to show if this effect can be sustained, as well as to ascertain its impact on allergic disease. More well-designed trials are still required before we can give any conclusive advice to our patients. Considering the management of allergy, current evidence suggests that interventions in children (either single or multifaceted) may be associated with some beneficial effect on asthma control, but no conclusive evidence exists regarding rhinitis or eczema. Conversely, there is little evidence to support the recommendation of allergen avoidance methods in adults with asthma and rhinitis. There is a need for an adequately designed trial assessing the effects of a multifaceted intervention in this age group.     

CLINICAL TRIAL OF EGOCORT 1% CREAM

A double blind clinical trial was conducted with Egocort 1% Cream and plain aqueous cream applied to each half of the body in ten patients with eczema. The patients were assessed for erythema, papules, vesicles, scaling and pruritus at the beginning of treatment, after 7-14 days and again after a further 7-14 days.
The results show that Egocort 1% Cream is more effective in treating eczema than plain aqueous cream. The preparation was found pleasant to use and no side-effects were noted.     

基于数据挖掘的中医药治疗小儿湿疹组方用药规律研究

目的：通过应用中医传承辅助平台（V 2.5）挖掘中医药治疗小儿湿疹的组方用药规律,并对高频药物、用药模式及治疗思路进行探讨。方法：搜集国家知识基础设施数据库（CNKI）、中国学术期刊数据库（CSPD）及中文科技期刊数据库（CCD）中2000—2021年应用中医药治疗小儿湿疹的相关文献,经过筛选后建立方药数据库,运用中医传承辅助平台（V 2.5）集成的改进互信息法、关联规则Apriori算法、复杂系统熵聚类与无监督熵聚类等算法对药物频次、性味归经、用药模式、规则分析及新处方等结果进行输出,并进行网络可视化展示。结果：纳入处方200首,共涉及206味中药,高频药物包括甘草、白鲜皮、薏苡仁、茯苓、生地黄、金银花、蝉蜕、地肤子、防风、牡丹皮等,药性以寒性（52.76%）居多,药味以甘（38.89%）、苦（33.37%）、辛（21.96%）味为主,归经以胃经（1 138次）、脾经（1 088次）、肝经（1 061次）居多,并且得到药物之间的关联规则,以及新处方6个。结论：小儿湿疹用药以补虚药、利水渗湿药、清热药、清热解毒药、解表药为主,治疗以疏风清热,燥湿健脾,养血活血为主要大法,分析结果与本病诊疗指南较为吻合,可为小儿湿疹的临床治疗及新药开发提供参考。     

湿疹Ⅰ号搽剂的制备工艺研究

目的　探讨湿疹I号搽剂的最佳制备工艺。方法　采用比较法和正交试验法 ,对湿疹Ⅰ号搽剂的制备工艺进行优选。结果　以蛇床子 8倍量 75 %乙醇浸泡 7d ,残渣与其余药材加 12倍量水、煎煮 2次、煎 6 0min为最佳。结论　该工艺可用于指导本制剂的生产     

硝酸益康唑对葡萄球菌体外抗菌活性的研究

目的为了解和评价硝酸益康唑在体外对葡萄球菌的抗菌活性和效果,以及其与6种临床常用抗菌药物对葡萄球菌抗菌活性的比较。方法从湿疹和特应性皮炎患者皮损处分离的257株葡萄球菌,采用肉汤稀释法对硝酸益康唑、新霉素、青霉素、红霉素、环丙沙星、阿米卡星和头孢噻肟进行最小抑菌浓度测定。结果对甲氧西林敏感金黄色葡萄球菌(MSSA),益康唑与新霉素、环丙沙星、阿米卡星、头孢噻肟MIC50值相近;对MRSA,益康唑MIC50明显低于其他6种抗菌药物;对甲氧西林敏感的表皮葡萄球菌(MSSE)MIC50与青霉素、环丙沙星、阿米卡星相同,低于新霉素、红霉素、头孢噻肟;对MRSE,益康唑的MIC50与青霉素、新霉素、环丙沙星、阿米卡星接近,低于头孢噻肟和红霉素。益康唑的MIC50和MIC90值相近。结论益康唑对葡萄球菌有明显的抗菌效果,益康唑的MIC50与MIC90值相近,目前未明显出现葡萄球菌对益康唑的耐药现象。     

丙酸氟替卡松治疗湿疹皮炎43例

目的：观察丙酸氟替卡松乳膏治疗湿疹、皮炎类皮肤病的临床疗效。方法：对43例湿疹、皮炎患者分别用0．05％丙酸氟替卡松乳膏（治疗侧）和0．1％糠酸莫米松乳膏（对照侧）治疗，qd，共2周。结果：两侧的临床症状、体征评分，治疗后第1周、第2周与治疗前比较明显降低（P〈0．01）。治疗侧与对照侧疗效比较差异无显著性（P〉0．05），均无不良反应发生。结论：0．05％丙酸氟替卡松乳膏治疗湿疹、皮炎类皮肤病有效、安全。     

RESOLUTION OF CUTANEOUS LEISHMANIASIS AFTER ACUTE ECZEMA DUE TO INTRALESIONAL MEGLUMINE ANTIMONIATE

We report a case of a 42 year-old female, who came to a leishmaniasis reference center in Rio de Janeiro, Brazil, presenting a cutaneous leishmaniasis lesion in the right forearm. Treatment with low-dose intramuscular meglumine antimoniate (MA) (5 mg Sb⁵⁺/kg/day) was initiated, with improvement after 28 days, although with the development of generalized eczema. After 87 days, the lesion worsened. Patient refused treatment with amphotericin B. MA was then infiltrated in the lesion, in two sessions, resulting in local eczema, with bullae formation; however, twenty days after, both the ulcer and eczema receded. Intralesional administration of MA should be used carefully when previous cutaneous hypersensitivity is detected.