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1.
目的检测疱疹性咽峡炎患儿血清生长分化因子-15(GDF-15)和肽素水平,探究其与患儿发生心肌损伤的相关性。 方法选取2016年1月至2019年1月广元市中医医院收治疱疹性咽峡炎患儿398例为研究对象,其中单纯疱疹性咽峡炎患儿214例(对照组),疱疹性咽峡炎合并心肌损伤患儿184例(观察组)。采集所有受试者外周静脉血,常规分离血清,采用酶联免疫吸附法检测血清GDF-15、肽素水平及心肌损伤标志物心肌肌钙蛋白Ⅰ(cTnⅠ)水平,采用DXC600全自动生化仪检测血清磷酸肌酸激酶(CK)和酸激酶同工酶(CK-MB)水平。采用Pearson法分析血清GDF-15、肽素与CK-MB、cTnⅠ的相关性;采用Logistic回归分析影响疱疹性咽峡炎患儿并发心肌损伤的危险因素;绘制受试者工作特性曲线(ROC)分析血清GDF-15、肽素与CK-MB、cTnI水平对疱疹性咽峡炎患儿发生心肌损伤的诊断价值。 结果观察组与对照组患儿性别、年龄和病程差异无统计学意义(χ2 = 0.672,t = 0.585、0.576,P均> 0.05);与对照组比较,观察组患儿白细胞(WBC)、中性粒细胞(GRAN)及血清超敏C-反应蛋白(hs-CRP)、GDF-15、肽素、CK、CK-MB和cTnⅠ水平显著升高,心电图异常比例显著增加,差异均有统计学意义(t = 21.237、18.324、33.084、13.535、17.192、21.859、39.014、24.369,χ2 = 28.097,P均< 0.05)。Pearson法相关性分析显示,疱疹性咽峡炎合并心肌损伤患儿血清GDF-15、肽素与CK-MB、cTnⅠ水平分别呈正相关(r = 0.530、0.427、0.443、0.440,P均< 0.05)。血清GDF-15、肽素、CK-MB和cTnⅠ水平升高均为影响疱疹性咽峡炎患儿发生心肌损伤的独立危险因素(P均< 0.05)。血清GDF-15、肽素、CK-MB和cTnⅠ水平诊断疱疹性咽峡炎患儿心肌损伤的曲下面积(AUC)分别为0.862、0.894、0.886和0.973,灵敏度分别为81.10%、84.20%、85.30%和90.20%,特异度分别为79.00%、81.30%、91.40%和94.90%,血清GDF-15、肽素联合检测的AUC为0.953,灵敏度为94.60%,特异度为84.10%。 结论疱疹性咽峡炎患儿血清GDF-15和肽素水平显著升高,与心肌损伤标志物CK-MB、cTnⅠ蛋白水平呈正相关,是影响疱疹性咽峡炎患儿发生心肌损伤的独立危险因素,二者联合检测可能对诊断疱疹性咽峡炎合并心肌损伤有一定参考价值。  相似文献   
2.
目的探讨经皮肾镜碎石术后,肾盂尿培养联合血清和肽素及IL-6水平对尿路感染的诊断价值。方法选取2015年6月-2018年6月于遵义医科大学附属医院行经皮肾镜碎石术的住院患者201例,根据术后尿路感染情况分为感染组32例及非感染组169例。术前中段尿、术中肾盂尿进行细菌培养,术后第1天采用酶联免疫吸附法检测血清和肽素及白细胞介素-6(Interleukin-6,IL-6)水平,比较上述指标单独及联合对术后尿路感染的诊断价值。结果感染组与非感染组术前中段尿细菌培养阳性率分别为15.63%和14.79%,差异无统计学意义(χ^2=1.218,P=0.270);感染组肾盂细菌培养阳性率为81.25%,高于非感染组的3.55%,差异有统计学意义(χ^2=121.349,P<0.001)。感染组和肽素及IL-6水平高于非感染组,差异有统计学意义(P<0.001)。肾盂尿培养、血清和肽素及IL-6联合诊断PCNL术后尿路感染敏感性为90.65%,特异性为86.44%,AUC为0.873±0.039,高于肾盂尿培养、和肽素、IL-6单独诊断水平(P<0.05)。结论术中肾盂尿培养较术前中段尿培养价值高,且血清和肽素、IL-6及肾盂尿培养联合诊断可提高诊断准确率。  相似文献   
3.
Objective: The aim of this study was to compare maternal and fetal serum copeptin concentrations in pregnancies complicated by isolated fetal growth restriction (FGR), and uncomplicated pregnancies, and to investigate relationships between copeptin levels and clinical parameters.

Methods: Maternal and fetal serum copeptin levels were measured in 21 women with pregnancies complicated by isolated FGR and 20 women with normal pregnancies (control group). Doppler assessment of the uterine and umbilical arteries was performed in each patient.

Results: Maternal serum copeptin levels were significantly higher in women with isolated FGR compared to controls (p?=?0.042). In addition, maternal copeptin levels were inversely correlated with the uterine artery pulsatility and resistance indices and positively correlated with neonatal birth weight. Umbilical vein copeptin levels were significantly increased in neonates with adverse outcomes (p?=?0.001).

Conclusions: Increased maternal copeptin concentration may reflect a response to stress, thus serving as a compensatory mechanism in pregnancies complicated by FGR.  相似文献   

4.
目的:探讨急性中毒心肌损伤早期检测和肽素与缺血修饰白蛋白( IMA)的临床意义。方法将急性中毒3 h内患者255例,根据是否存在心肌损伤分为心肌损伤组160例(其中轻度30例、中度60例、重度70例)和非心肌损伤组95例,另选健康体检者50例作为对照组。比较3组心肌酶、心肌肌钙蛋白 I( cTnI)、和肽素、IMA 水平。结果心肌损伤组、非心肌损伤组患者和肽素水平明显高于对照组(P<0.05),且心肌损伤组明显高于非心肌损伤组(P<0.05),重度组高于心肌损伤轻、中度组(P<0.05);心肌损伤组IMA水平明显低于对照组和非心肌损伤组(P<0.05),重度组低于心肌损伤轻、中度组(P<0.05)。心肌损伤组、非心肌损伤组、对照组肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、cTnI水平比较,差异均无统计学意义(P>0.05)。心肌损伤重度组患者cTnI水平明显高于轻、中度组(P<0.05),但轻、中度两组间cTnI水平比较无统计学意义(P>0.05)。心肌损伤轻、中、重度组患者CK、CK-MB比较,差异均无统计学意义(P>0.05)。心肌损伤组患者和肽素与IMA水平呈负相关(r=-0.603,P<0.01)。结论和肽素、IMA水平可在早期反映急性中毒性心肌损伤程度并评估预后转归情况。  相似文献   
5.
目的:观察活血通脉胶囊对冠心病心血瘀阻证患者血浆小分子代谢产物的调节作用。方法采用前瞻性研究方法,选择2009年1月至2013年12月在天津市大港地区就诊的136例冠心病心血瘀阻证患者,按简单随机抽样方法分成两组。对照组(68例)采用硝酸酯类、β受体阻滞剂、钙离子拮抗剂及肠溶阿司匹林等常规疗法;活血通脉胶囊组(68例)在常规治疗基础上给予活血通脉胶囊,每次4粒(每粒0.25 g),每日3次,30 d为1个疗程,共3个疗程。评定两组治疗后临床疗效和心电图疗效;采用酶联免疫吸附试验(ELISA)检测血浆和肽素、肿瘤坏死因子-α(TNF-α)及白细胞介素-10(IL-10)水平,计算TNF-α/IL-10比值。结果活血通脉胶囊组临床疗效及心电图疗效均明显高于对照组〔临床总有效率:89.71%(61/68)比80.88%(55/68);心电图总有效率:57.35%(39/68)比48.53%(33/68),均P<0.05〕。两组治疗后和肽素及TNF-α/IL-10比值均较治疗前明显降低,且以活血通脉胶囊组降低更显著〔和肽素(ng/L):0.22±0.04比0.31±0.05,TNF-α/IL-10比值:0.49±0.11比0.65±0.09,均P<0.05〕。结论在常规疗法基础上加用活血通脉胶囊能通过降低和肽素水平及TNF/IL-10比值来改善冠心病心血瘀阻证患者的治疗效果。  相似文献   
6.
《Diabetes & metabolism》2020,46(3):203-209
AimsCopeptin, a surrogate of vasopressin, is elevated in type 1 diabetes (T1D) and predicts kidney disease and cardiovascular mortality. Given the cardiorenal protective effects of SGLT2 inhibition (SGLT2i), our aim was to examine: 1) the relationship between serum copeptin, metabolic, renal and systemic hemodynamic parameters in adults with T1D; and 2) serum copeptin after SGLT2i with empagliflozin.Materials and methodsIn this post-hoc, exploratory analysis, serum copeptin, glomerular filtration rate (GFRInulin), effective renal plasma flow (ERPFPAH), plasma renin angiotensin aldosterone system markers, HbA1c, 24-hour urine volume and sodium excretion were measured in 40 participants with T1D (24.3 ± 5.1 years) during eu- and hyperglycaemia before and after 8 weeks of 25 mg of daily empagliflozin.ResultsHigher baseline copeptin correlated with higher HbA1c, lower 24-hour urine volume and sodium excretion, after correcting for age, sex, systolic blood pressure, and HbA1c. Copeptin concentrations increased in response to empagliflozin under euglycaemia (4.1 ± 2.1 to 5.1 ± 2.8 pmol/L, P = 0.0053) and hyperglycaemia (3.3 ± 1.4 to 5.6 ± 2.8 pmol/L, P < 0.0001). The rise in copeptin in response to empagliflozin correlated with change in 24-hour urine volume, but was independent of changes in fractional excretion of sodium and haematocrit.ConclusionsElevated serum copeptin was associated with worse glycaemic control and lower diuresis and natriuresis. SGLT2i increased serum copeptin in adults with T1D, and the rise correlated with change in diuresis, but not natriuresis and hemo-concentration. Further work is required to evaluate the clinical implications of elevated copeptin with SGLT2i, including whether it is simply a marker of diuresis or may contribute to cardiorenal disease long-term.  相似文献   
7.
目的分析BiPAP呼吸机联合坎地沙坦酯对肺心病急性期合并呼吸衰竭老年患者心肺功能及血清内皮素(ET)-1、Clara细胞蛋白(CC)16、和肽素(Copeptin)水平的影响。方法96例肺心病急性期合并呼吸衰竭老年患者随机分为两组各48例,对照组接受BiPAP无创呼吸机治疗,观察组接受BiPAP无创呼吸机联合坎地沙坦酯治疗。比较两组治疗2 w后的疗效、心肺功能指标及血清ET-1、CC16和Copeptin水平,并统计不良反应发生情况。结果观察组总有效率较对照组显著高(P<0.05)。治疗2个疗程后观察组肺动脉压(PASP)显著低于对照组,而每搏输出量(SV)、射血分数(EF)、舒张早期峰值速度与舒张晚期峰值速度比值(E/A)、1 s用力呼气容积(FEV1)/用力肺活量(FVC)、FEV1%、呼吸流量峰值(PEF)指标水平显著高于对照组(P<0.05)。两组治疗后血清ET-1、CC16和Copeptin水平均显著下降,且观察组降低较多(P<0.05)。主要不良反应为低血压、头痛、恶心、发热等,两组发生率无统计学差异(P=0.726)。结论BiPAP呼吸机联合坎地沙坦酯对老年患者肺心病急性期合并呼吸衰竭疗效显著。  相似文献   
8.
目的:分析血清可溶性生长刺激表达基因2蛋白(sST2)、apelin及和肽素(CPP)水平与不同射血分数心力衰竭患者预后的相关性。方法:选择2018年11月至2020年5月在福建省立金山医院诊断为心力衰竭的119例患者,根据左室射血分数,将其分为射血分数降低组(HFrEF组,n=31)、射血分数中间值组(HFmrEF组,n=21)和射血分数保留组(HFpEF组,n=67)。检测3组患者血清中N末端脑钠肽前体(NT-proBNP)、sST2、apelin和CPP的含量。所有患者入院后根据指南规范化治疗心力衰竭,随访2年,分析各心脏生物学标志物与心血管死亡之间的关系。结果:3组间患者性别、收缩压、脉压、体质量指数、尿素氮、糖化血红蛋白、左心室舒张末期内径、右心房横径、右心室舒张末期内径差异均有统计学意义(P0.05)。3组患者血清中NT-proBNP和sST2含量差异有统计学意义(P0.05),CPP和apelin含量差异无统计学意义。多元线性模型分析结果显示,血清NT-proBNP水平与左室射血分数相关(F=3.49,P=0.03),而血清sST2、apelin、CPP水平与左室射血分数无相关性。随访24个月时HFrEF组、HFmrEF组、HFpEF组患者累计心血管死亡率分别为29.0%、23.8%、10.4%,差异有统计学意义(P=0.04)。Kaplan-Meier生存分析显示,HFrEF、HFmrEF、HFpEF组心血管病累计生存率依次升高(χ~2=6.48,P=0.04)。Cox回归分析结果显示,NT-proBNP、尿素氮水平及使用盐皮质激素受体拮抗剂是心力衰竭患者心血管死亡的独立影响因素(P0.01)。结论:左室射血分数、NT-proBNP、尿素氮水平及使用盐皮质激素受体拮抗剂对心力衰竭患者心血管死亡有预测作用,而血清sST2、apelin和CPP水平预测价值有限。  相似文献   
9.
IntroductionCoronary artery disease (CAD) is an ischemic heart disease due to the narrowing of the coronary arteries resulting from atherosclerosis. Blood biomarkers have been well utilized for the diagnosis and prognosis of CAD. However, the value of biomarkers for evaluating coronary atherosclerosis remains to be clarified. This clinical investigation aimed to explore the potential value of biomarkers for evaluating the severity of coronary stenosis in CAD patients.MethodsThe extent of coronary atherosclerosis was accessed by the angiography-based quantitative measurement Gensini score (GS). Blood levels of Brain natriuretic peptide, Copeptin (CPP), Phosphodiesterase 9A, and Pentraxin3 (PTX3) were measured in 56 patients divided into three levels as low GS (n = 17), intermediate GS (n = 19) and high GS (n = 20) based on GS tertiles.ResultsWe found that plasma concentrations of CPP and PTX3 were significantly elevated in patients with high GS compared with the low GS group. In addition, Pearson correlation analysis showed that CPP and PTX3 were positively correlated with the GS. Furthermore, Receiver operating characteristics analysis demonstrated that both CPP and PTX3 exhibited discriminative capacities for evaluating the extent of coronary stenosis.ConclusionsLaboratory tests of CPP and PTX3 via non-invasive means may provide novel information for risk stratification and disease management in CAD patients before invasive angiographic approaches. This study opens the door for enormous opportunities to explore new biomarkers with better efficiency, sensitivity and specificity as alternative/additional methods for evaluating the severity of coronary atherosclerosis in CAD patients in future research.  相似文献   
10.
目的研究ST段抬高性急性心肌梗死(STEAMI)患者的血浆和肽素浓度对其住院期间主要不良心脏事件(MACE)的预测价值。方法纳入STEAMI患者和健康体检者(对照组)各102例,对照组静脉血体检时获得,STEAMI患者静脉血在入院时获得。血浆和肽素浓度用酶联免疫吸附测定法检测。结果STEAMI组血浆和肽素浓度(539±294)Pg/mL显著高于对照组(57±24)Pg/mL(t=16.323,P〈0.001)。Logistic回归分析显示,血和肽素浓度(OR=1.008,95%CI=1.004—1.011,P〈0.001)和血心肌肌钙蛋白I(cardiac troponin I,cTnI)浓度(OR=16.271,95%CI=2.423~109.282,P=0.004)是STEAMI患者住院期间MACE的独立危险因素。受试者工作特征(ROC)曲线分析显示,血浆和肽素浓度(ROC曲线下面积(AUC)=0.887,95%CI=0.809—0.941)和cTnI浓度(AUC=0.711,95%CI=0.613~0.796)对STEAMI患者住院期问发生的MACE均有显著预测价值,而血浆和肽素浓度ROC曲线下面积显著大于cTnI浓度G=2.392,P=0.017)。结论STEAMI患者血浆和肽素浓度显著升高,故检测该指标有助于临床早期预测STEAMI患者住院期间MACE的发生。  相似文献   
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