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1.
《Drug discovery today》2022,27(5):1350-1366
The screening of compound–protein interactions (CPIs) is one of the most crucial steps in finding hit and lead compounds. Deep learning (DL) methods for CPI prediction can address intrinsic limitations of traditional HTS and virtual screening with the advantage of low cost and high efficiency. This review provides a comprehensive survey of DL-based CPI prediction. It first summarizes popular databases of small-molecule compounds, proteins and binding complexes. Then, it outlines classical representations of compounds and proteins in turn. After that, this review briefly introduces state-of-the-art DL-based models in terms of design paradigms and investigates their prediction performance. Finally, it indicates current challenges and trends toward better CPI prediction and sketches out crucial approaches toward practical applications.  相似文献   
2.
目的 评价基于“肺脾”理论指导穴位埋线治疗变应性鼻炎的有效性。 方法 计算机检索CNKI(2000.1~2021.2)、VIP(2000.1~2021.2)、WANGFANG(2000.1~2021.2)、Pubmed(2000.1~2021.2)数据库中发表的与穴位埋线治疗变应性鼻炎相关的随机对照实验。对筛选出来的全部文献由2名研究者单独进行文献的筛选、质量评价、提取相关数据,采用RevMan5.4进行Meta分析。 结果 符合纳入标准的文献共12篇,病例931例。Meta分析结果显示穴位埋线组治疗变应性鼻炎有效率优于对照组(RR=1.29,95%CI:1.22,1.38,P<0.000 01);穴位埋线组复发率与对照组相比,差异有统计学意义(RR=0.3,95%CI:0.16,0.55,P<0.000 1);穴位埋线组治疗前后症状体征总积分与对照组相比,差异有统计学意义[SMD=-0.97,95%CI(-1.51,-0.43),P=0.000 4; 结论 根据符合纳入标准的12篇文献显示,穴位埋线法治疗变应性鼻炎疗效更佳,复发率更低,但由于纳入文献质量、数量有限,存在一定的发表偏倚,因此上述分析结论等待开展更多更高质量的研究来进一步证明。  相似文献   
3.
目的:观察揿针疗法分经论治神经根型颈椎病的临床疗效及可行性.方法:将70例神经根型颈椎病患者随机分为观察组与对照组,每组35例.对照组采用常规取穴的揿针疗法,观察组采用分经辨证取穴的揿针疗法.在治疗前后对两组患者的视觉模拟量表(VAS)评分及临床症状评分进行评价,并观察两组治疗方案的临床疗效.结果:治疗后,两组患者的VAS评分均较治疗前降低(均P<0.01),且观察组患者VAS评分低于对照组(P<0.01);两组患者的临床症状评分均较治疗前降低(均P<0.01),且观察组患者的临床症状评分低于对照组(P<0.01);观察组的临床总有效率高于对照组(P<0.05).结论:分经辨证取穴的揿针疗法能够降低神经根型颈椎病患者的疼痛评分,改善患者的临床症状,疗效优于常规揿针疗法.  相似文献   
4.
变应性鼻炎相当于中医鼻鼽范畴,属于中医优势病种,是常见多发疾病。导师张勤修教授擅长采用中医外治法治疗变应性鼻炎,提出气血调衡是穴位埋线治疗变应性鼻炎的作用机制之一。现就此作用机制进行阐述,以期为穴位埋线治疗变应性鼻炎的临床推广奠定理论基础。  相似文献   
5.
《中医杂志(英文版)》2014,34(5):566-571
ObjectiveTo investigate the effect of catgut implantation at acupoints on the expressions of γ-amino butyric acid B receptor (GABAB) and metabotropic glutamate receptor 1 (mGluR1) in the brain stem of rats with spasticity after stroke.MethodsIn total, 60 male Sprague-Dawley rats were randomly divided into three groups: a sham group (n=10), a model group (n=25) and a treatment group (n=25). The rats in both the model group and the treatment group were subjected to middle cerebral artery occlusion to establish a model of focal cerebral ischemia. Rats with limb-spasm met the inclusion criteria. Only the left carotid artery was isolated in sham group rats. Three days after modeling, the treatment group was subjected to catgut implantation at Dazhui (GV 14), Guanyuan (CV 4), and Zhongwan (CV 12). Neurological deficit symptoms were assessed with the Zea-Longa neurological deficit score. The Modified Ashworth Scale (MAS), and isolated muscle tone were used to evaluate spasticity before and after treatment. Immunohistochemistry was applied to determine the expression of GABAB and mGluR1 in the rat brain stem after treatment.ResultsAfter treatment, neural impairment symptoms had significantly improved in the treatment group when compared to the model group (P<0.05). Both MAS and isolated muscle tone in the treatment group were significantly decreased when compared with the model group (P<0.05), and were also lower than before treatment. GABAB expression was significantly higher and mGluR1 was lower in the treatment group when compared with the model group (P<0.01 and P<0.05, respectively).ConclusionCatgut implantation at Dazhui (GV 14), Guanyuan (CV 4), and Zhongwan (CV 12), can relieve limb spasticity by increasing the expression of GABAB and reducing the expression of mGluR1 in the brain stem of rats after stroke.  相似文献   
6.
目的:通过动物实验验证穴位埋线治疗变应性鼻炎(AR)的疗效,并从鼻黏膜免疫微环境方面探讨其作用机制。方法将70只健康 SPF 级 S D大鼠随机分为空白组、AR 模型组、AR 西药组、AR 穴位假埋线组、AR 穴位埋线组。造模方法采用改进后的卵蛋白注射及其鼻黏膜刺激法。除空白组外各组予以不同治疗方法,治疗末日在卵白蛋白激发后,观察30 min,观察大鼠 AR 症状,记录并比较各组大鼠鼻部症状评分,之后立即处死动物,采集大鼠鼻中隔黏膜,采用免疫组化方法检测鼻黏膜组织 TGF-β1、IL-17的表达情况。结果穴位埋线能明显缓解AR 大鼠鼻部症状,如喷嚏、流涕、抓搔鼻部。与模型组比较,穴位埋线能降低鼻黏膜中 TGF-β1、IL-17含量。穴位假埋线也能降低 AR 大鼠鼻黏膜中 TGF-β1含量。结论穴位埋线可降低 AR 大鼠鼻黏膜中 TGF-β1、IL-17含量,从而调节 AR 大鼠鼻黏膜免疫微环境。  相似文献   
7.
目的:探讨输尿管镜嵌顿的预防及处理。方法:对3500例输尿管镜检及输尿管镜下气压弹道碎石术术中发生输尿管镜嵌顿的病例资料作回顾性分析。结果:3500例患者中,发生输尿管镜嵌顿14例,其中,男8例,女6例,平均年龄44.5岁。嵌顿部位位于上段输尿管2例,中段3例,下段9例。8例成功退镜,6例失败(其中4例行开放输尿管纵向切开退镜、输尿管吻合或移植术,2例因输尿管严重撕脱行肾脏切除),随访1 - 3年,预后良好。结论:输尿管镜是诊断和治疗输尿管疾病的常用方法,操作不当可导致严重的并发症,如能妥善处理,则预后良好。  相似文献   
8.
C. Walton Lillehei (1918–1999) represents the most distinguished American surgeon of his time and perhaps the greatest surgeon in history. As his mentor, Owen H. Wangenesteen (1898–1981), so accurately declared, Walt Lillehei was “one of the surgical immortals.” Indeed, similar words were echoed by the famous cardiac surgeon, Denton A. Cooley (b. 1920), who said, “Hardly any other cardiac surgeon has introduced a greater number of innovative techniques and concepts.”

Born in Minneapolis, Lillehei attended the University of Minnesota, where he completed his college, medical, physiology, and surgical studies. Because of his extraordinary contributions to make open heart surgery feasible and safe, he is considered the father of open heart surgery. Many other contributions followed the initial innovations, particularly the use of the bubble oxygenator, the total intracardiac repair of tetralogy malformation, the use of myocardial electrodes for treating complete heart block, and the development of three cardiac valve prostheses, among other discoveries.

The noted Minnesota surgeon was an innovator for his entire professional career. He believed in innovation and practiced innovation in any way possible. “Determination, persistence, and stubbornness” were, according to Lillehei, “the most important components of research and successful discovery.”  相似文献   
9.
Background: Deficits in the production of complex structures have been widely documented in non-fluent forms of aphasia. Nevertheless, the data available on fluent deficits are scarcer. In both cases, reduced complexity is attributed to syntactic factors. In the related field of syntactic theory, there exist a number of studies on the production of non-brain damaged (NBD) subjects which try to account for the existence of two alternative constructions in embedded complement clauses in English (as in I think that the situation will improve/I think the situation will improve). The absence of that in the embedded clauses of verbs like say, know or think in colloquial English is very frequent and this suggests that verbs of this type may select a clause lacking a complementiser phrase (CP) layer, namely tense phrase (TP). The presence of that is taken to be the result of insertion, which is triggered by cues associated to contextual factors like register.

Aims: To compare the presence and absence of the complementiser that in the speech of English subjects diagnosed with aphasia with the same phenomenon in NBD subjects with the objective of clarifying the nature of the phenomenon of that-omission.

Methods &; Procedures: We carried out an analysis of spontaneous speech that included the performance of 200 individuals brought together by the AphasiaBank project. Two groups were included in the study, an experimental group comprising 100 individuals diagnosed as aphasic according to the standards of the Western Aphasia Battery (WAB), and a control group including 100 non-brain damaged control subjects ( NBDs).

Outcomes &; Results: This study shows that the asymmetries across populations (NBDs vs. subjects with aphasia) are restricted to the number of occurrences of subordinate clauses. NBD subjects produce more embeddings than subjects diagnosed with fluent aphasia (although they do produce embedded clauses and crucially prefer the “omission” option) and subjects with non-fluent aphasia.

Conclusions: Our results confirm the findings on fluent aphasias as for the presence of deficits with complex constructions. These results may be regarded as evidence for the claim that TP is the default selection for the verbs analysed.  相似文献   
10.
目的 比较在针药复合麻醉肺切除手术中运用微创埋线与全麻的麻醉效果,为针麻肺切除手术探索新的方法提供临床依据。方法 将50例肺切除手术患者随机分为治疗组和对照组,每组25例。治疗组术前予以微创埋线,取穴华佗夹脊(T4、T6、T8)与背俞穴(肺俞、心俞、膈俞)、曲池、足三里。对照组采用全麻。记录两组术中11个时间点的生理指标,计量术中麻醉药物实际使用量等指标。结果 两组术中11个时间点心率、收缩压与舒张压比较,差异均无统计学意义(P>0.05)。治疗组术中芬太尼追加量与对照组比较,差异具有统计学意义(P<0.05)。两组术中丙泊酚及罗库溴铵追加量比较,差异均无统计学意义(P>0.05)。结论 微创埋线相对于全麻方案,能减少手术中镇痛药物的使用剂量,微创埋线与药物在肺切除手术中具有良好的协同作用。  相似文献   
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