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目的:观察补肺片对支气管哮喘缓解期患者外周血CD4^+、CD8^+及血清IgE的影响。方法:将104例患者随机分为2组各52例,2组急性期均给予常规西医处理(解痉、平喘、抗炎)。缓解期治疗组采用补肺片治疗,对照组不施加特殊治疗,治疗3月后检测CD4^+,CD8^+及血清IgE变化。结果:治疗组CD4^+、IgE水平较对照组明显降低,CD8^+较对照组明显增加,2组治疗后比较,差异有显著性或非常显著性意义(P〈0.05,P〈0.01)。结论:补肺片可通过降低CD4^+,升高CD8^+,从而降低IgE水平,抑制气道炎症,降低气道高反应性,从而控制哮喘发作。  相似文献
2.
中药复方提取物HNA-1治疗猴免疫缺陷病毒感染的实验研究   总被引:1,自引:0,他引:1  
目的:研究中药复方提取物HNA-1治疗猴免疫缺陷病毒(SIV)感染的作用。方法:采用SIVmac239毒株静脉感染15只中国恒河猴,待感染10周病毒载量进入平台期后,将动物随机分为高剂量组、低剂量组和模型对照组,分别灌胃给予1.8g.kg-1.d-1和0.6g.kg-1.d-1HNA-1药物以及等容量温开水;给药治疗8周,之后停药观察8周。观察、检测动物的一般情况、血浆病毒载量、CD4+和CD+8T细胞、血细胞学和活检淋巴结病理改变等。结果:模型对照组在观察期间有2例动物死亡,而治疗组动物均存活;且治疗组动物在体质量、CD4+T细胞数上均显著优于模型对照组(P<0.05);活检淋巴结病理检查显示,治疗组动物淋巴组织保存较好,部分原本淋巴组织结构已发生退变甚至耗竭的动物,经治疗后出现了恢复。结论:中药复方提取物HNA-1虽然不能直接起到抗SIV的作用,但可以提高动物体质量、减少动物死亡、提高CD4+T细胞数、改善淋巴结组织结构的病理退变,对SIV感染导致的免疫系统破坏具有一定的保护作用。  相似文献
3.
补肾宣肺方治疗肾阳虚咳嗽变异性哮喘临床研究   总被引:1,自引:0,他引:1  
目的观察补肾宣肺方联用西药治疗肾阳虚咳嗽变异性哮喘(CVA)的疗效。方法80例CVA患者随机分为对照组和治疗组,每组40例。对照组口服氨茶碱缓释片0.1~0.2g,2次/d;酮体芬片1mg,1次/d。治疗组在对照组基础上予补肾宣肺方口服。2组均以4周为1个疗程,在第5周评价疗效。结果治疗后2组CD8^+细胞显著升高,CD4^+ 细胞、IgE水平则显著降低,且治疗组与对照组差异有统计学意义(P〈0.05或P〈0.01);治疗组总有效率为87.5%,显著高于对照组的70.0%(P〈0.05);治疗组临床控制患者咳嗽平均缓解天数为(11.5±4.8)d,与对照组(19.3±5.2)d比较,差异亦有统计学意义(P〈0.05)。结论补肾宣肺方联用西药治疗肾阳虚CVA疗程较短,且能改善机体免疫功能。  相似文献
4.
目的 探讨慢性再生障碍性贫血(chronic aplastic anemia,CAA)患者外周血CD8^+T细胞CD28分子的表达与中医辨证分型的关系、方法采用流式细胞仪技术,测定门诊和住院CAA患者45例、健康对照人群24名的外周血CD8^+T细胞CD28分子的表达水平,从免疫学角度讨论其与中医分型关系一结果(1)CAA患者的CD8、CD28、CD8^+CD28^+表达水平及CD8^+CD28^+/CD8^+CD28均高于健康对照组(P<0.01,P<0.05)。(2)CAA肾阴虚患者CD28、CD8^+CD28^+表达水平及CD8^+CD28^+/CD8^+CD28均高于肾阳虚患者(P<0.01,P<0.05)。结论 (1)CAA患者外周血共刺激分子CD28异常高表达,提示CD28失调可能在CAA免疫发病中起重要作用、(2)CAA患者外周血CD28、CD8^+CD28^+的表达水平及CD8^+CD28^+/CD8^+CD28可以作为CAA辨证分型的参考指标,肾阴虚患者的免疫紊乱较肾阳虚患者严重。  相似文献
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目的观察艾滋病中医脏腑气虚证候与CD4+、CD8+T淋巴细胞相关性。方法通过对艾滋病中医脏腑气虚证候患者免疫学指标的观察,初步探讨艾滋病肺气亏虚证、脾气亏虚证、肾气亏虚证与CD4+、CD8+T淋巴细胞的内在相关。结果 153例患者中,肺气虚证患者48例,脾气虚证患者70例,肾气虚证患者35例;CD4+和CD8+T淋巴细胞计数、CD4+/CD8+T比值比较:肺气虚证与脾气虚证、肾气虚证比较有统计学意义(P<0.05),脾气虚证与肾气虚证比较则无统计学意义(P>0.05)。结论艾滋病肺气虚证患者较脾气虚证、肾气虚证患者CD4+、CD8+T淋巴细胞下降更明显,CD4+/CD8+比例失调更显著,其免疫损伤和破坏更严重,更易发生机会性感染,病情亦相对较重。  相似文献
6.
OBJECTIVE: To study the effects of cold-dryness on pulmonary and immunologic function of peripheral T-lymphocytes in chronic obstructive pulmonary disease (COPD) model rats, and to provide references for the prevention and treatment of cold-dryness COPD in the Xinjiang region. METHODS: The COPD model was established with an elastase drip into the trachea combined with smoking. The cold-dryness COPD model was developed by stressing with a cold-dry environment. Success of the model was determined by observation of pathologic lung sections. Rats were sacrificed by exsanguination from the femoral artery and changes of peripheral blood CD4+, CD8+, and CD4+/CD8+ were detected by flow cytometryo Data were analyzed with SAS 11.5 statistical software. RESULTS: On the ninetieth day after ending the ex- periment, Peak expiratory flow in the cold-dryness COPD group was lower than that in the COPD and normal control groups (P〈0.01). The time of inspiration in the cold-dryness COPD group was higher than that in the COPD and normal groups (P〈0.05). Time of expiration (Te) in the cold-dryness COPD group was higher than that in the COPD and normal groups (P〈0.01). 50% tidal volume expiratory flow (EFS0) in the cold-dryness COPD group was lower than that in the COPD and normal groups (P〈 0.01), and EFS0 in the COPD group was lower than that in the normal group (P〈0.05). CD4+ content of peripheral blood in the cold-dryness COPD group was lower than that in the COPD and the normal groups (P〈0.05). CD8+ content in the cold-dryness COPD and COPD groups was higher than that in the normal control group (P〈0.01), and CD8+ content in the cold-dryness COPD group was higher than that in the COPD group (P〈0.01). CD4+/CD8+ in the cold-dryness COPD group and the COPD group was lower than that in the normal control group (P〈0.01), and CD4+/CD8+ in the cold-dryness COPD group was lower than that in the COPD group (P〈0.05). CONCLUSION: In the cold-dryness COPD model, CD8+ increased and CD4+/CD8+ decreased. Moreover, cold-dryness may aggravate this state. The effects of cold-dryness on pulmonary function main- ly manifested as prolongation of Te and decrease of EF50, which could be one of causes of cold-dryness environment in the northwest of China leading to COPD with region characteristics.  相似文献
7.

Objective

To study the effects of cold-dryness on pulmonary and immunologic function of peripheral T-lymphocytes in chronic obstructive pulmonary disease (COPD) model rats, and to provide references for the prevention and treatment of cold-dryness COPD in the Xinjiang region.

Methods

The COPD model was established with an elastase drip into the trachea combined with smoking. The cold-dryness COPD model was developed by stressing with a cold-dry environment. Success of the model was determined by observation of pathologic lung sections. Rats were sacrificed by exsanguination from the femoral artery and changes of peripheral blood CD4+, CD8+, and CD4+/CD8+ were detected by flow cytometry. Data were analyzed with SAS 11.5 statistical software.

Results

On the ninetieth day after ending the experiment, Peak expiratory flow in the cold-dryness COPD group was lower than that in the COPD and normal control groups (P<0.01). The time of inspiration in the cold-dryness COPD group was higher than that in the COPD and normal groups (P<0.05). Time of expiration (Te) in the cold-dryness COPD group was higher than that in the COPD and normal groups (P<0.01). 50% tidal volume expiratory flow (EF50) in the cold-dryness COPD group was lower than that in the COPD and normal groups (P<0.01), and EF50 in the COPD group was lower than that in the normal group (P<0.05). CD4+ content of peripheral blood in the cold-dryness COPD group was lower than that in the COPD and the normal groups (P<0.05). CD8+ content in the cold-dryness COPD and COPD groups was higher than that in the normal control group (P<0.01), and CD8+ content in the cold-dryness COPD group was higher than that in the COPD group (P<0.01). CD4+/CD8+ in the cold-dryness COPD group and the COPD group was lower than that in the normal control group (P<0.01), and CD4+/CD8+ in the cold-dryness COPD group was lower than that in the COPD group (P<0.05).

Conclusion

In the cold-dryness COPD model, CD8+ increased and CD4+/CD8+ decreased. Moreover, cold-dryness may aggravate this state. The effects of cold-dryness on pulmonary function mainly manifested as prolongation of Te and decrease of EF50, which could be one of causes of cold-dryness environment in the northwest of China leading to COPD with region characteristics.  相似文献
8.
目的 观察升降散对脓毒症小鼠脾细胞中CD4^+、CD8^+、T细胞的影响。方法 雄性Balb/c小鼠84只,按随机数字表法分为正常组、假手术组、脓毒症组、升降散组,各组又分为6 h、12 h和24 h 3个时间点亚组。除正常组外,其余各组采用盲肠结扎穿孔术(CLP)制备脓毒症小鼠模型。各组在造模前72 h开始灌胃给药或0.9%Na Cl溶液,术后按各个时间点采用流式细胞仪方法检测小鼠脾细胞中CD4^+、CD8^+、T细胞占淋巴细胞百分比。结果 与脓毒症组相比,升降散组可显著上调CLP后6 h及12 h的CD4+水平,下调CLP后6 h及12 h的CD8+水平,差异均有统计学意义(P〈0.05)。结论 升降散可以纠正脓毒症初期小鼠的细胞免疫功能紊乱,具有免疫调节作用。  相似文献
9.
目的:探讨安胎灵与绒毛膜性腺激素/黄体酮合用治疗脾肾亏虚型复发性流产,并对其外周血中Th1/Th2偏倚的调节作用。方法:用安胎灵与绒毛膜性腺激素/黄体酮治疗脾肾亏虚型复发性流产患者,以治疗前后为对照,用流式细胞仪及ABC—ELISA法分别检测血CD4^+、CD8^+、CD4^+/CD8^+水平。结果:(1)60例复发性流产患者54例治愈,6例无效,治愈率90%。(2)CD4^+治疗前后差异无显著意义(P〉0.05)。(3)CD8^+治疗前后差异有极显著性意义(P〈0.01)。(4)CD4^+/CD8^+治疗前后比较差异有极显著性意义。结论:安胎灵与绒毛膜性腺激素/黄体酮合用可有效治疗脾肾亏虚型复发性流产,并调节患者外周血的Th1/Th2偏倚,降低流产风险。  相似文献
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