异丙酚持续静脉泵入麻醉对接受微波消融治疗的原发性肝癌患者血管内皮糖萼和脑代谢的影响

目的 探讨应用丙泊酚持续静脉泵注麻醉对接受手术治疗的原发性肝癌(PLC)患者血管内皮糖萼和脑代谢的影响。方法 2017年8月～2020年7月在我院行微波消融术治疗的PLC患者78例,其中一半患者接受异丙酚麻醉,另一半接受地佐辛麻醉。在术前(T0)、术后1 d(T1)和术后7 d(T2),行血气分析,计算脑氧摄取率(CEO₂),采用ELISA法检测硫酸乙酰肝素酶(HS)和多配体蛋白聚糖-1。结果 异丙酚麻醉组诱导时间和苏醒时间分别为(40.3±3.2) s和(6.5±0.8)min,显著短于地佐辛麻醉组【分别为(52.0±3.1) s和(9.8±1.1) min, P<0.05】;在T1和T2,异丙酚麻醉组HS分别为(17.3±2.1)pg/ml和(8.2±0.4)pg/ml,显著低于地佐辛麻醉组【分别为(37.2±5.6)pg/ml和(16.0±2.5)pg/ml,P<0.05】,血清多配体蛋白聚糖-1水平分别为(8.2±0.1)pg/ml和(3.8±0.1)pg/ml, 显著低于地佐辛麻醉组【分别为(11.7±1.4)pg/ml和(5.9±0.2) pg/ml,P<0.05】,CEO₂分别为(28.0±2.4)%和(32.7±3.7)%,显著高于地佐辛麻醉组【分别为(25.0±3.1)%和(29.7±4.1)%,P<0.05】。结论 应用异丙酚持续静脉泵注麻醉在接受微波消融治疗的PLC患者能抑制血管内皮糖萼的激活,改善脑代谢,提高麻醉效果,减少并发症的发生。     

Building an International Community of Paediatric Anaesthesiologists: An interview with Dr Edward Sumner

Dr Edward Sumner (1940) enjoyed a remarkably productive career as consultant pediatric anesthetist at the Great Ormond Street Hospital for Children. His leadership in clinical care helped his department rise to eminence. He trained hundreds of registrars in pediatric anesthesia and educated thousands more through invited lectures and by co‐editing leading textbooks of neonatal and pediatric anesthesia. During his long tenure as Editor‐in‐Chief of Pediatric Anesthesia, he led the growth of the young journal to prominence. Based on an interview and a long‐standing professional and personal friendship of forty‐four years, this article reviews Ted Sumner's outstanding contributions to the specialty of pediatric anesthesia and to the development of a strong international community of pediatric anesthesiologists.