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福建水华微囊藻的急性毒性及肝、肾脏损伤作用 总被引:1,自引:0,他引:1
目的 鉴定我省某水库中水华微囊藻的毒性。 相似文献
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目的探讨福建水华微囊藻毒素免疫毒性。方法80只雄性ICR小鼠随机分成4组,微囊藻毒素染毒剂量分别为0,8,16和24μg/kg,连续7d。第8天检测脾脏的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、乳酸脱氢酶(LDH)含量,巨噬细胞吞噬指数,T淋巴细胞CD4+、CD8+亚群的百分比,观察胸腺和脾脏的组织病理学改变。结果24μg/kg微囊藻毒素可使SOD和GSH-Px活性明显降低,LDH水平明显升高,吞噬指数明显下降,CD4+的百分比明显降低(P<0.05),胸腺皮质明显变薄,脾小体明显萎缩,淋巴细胞数明显减少。结论在本试验条件下,福建水华微囊藻毒素具有免疫毒性,可引起小鼠CD4+百分比下降,抑制巨噬细胞的吞噬能力,胸腺和脾脏出现病理改变。 相似文献
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Promoting Activity of Microcystins Extracted From Waterblooms in SHE Cell Transformation Assay 总被引:1,自引:0,他引:1
Microcystis aeruginosa is the dominant algae in most of the eutrophicated lakes in China.It can produce cyclic heptapeptides,Known as microcystins,which can cause liver damage in wild and comestic animals.In this paper,a two-stage transformation assay for demonstrating the carcinogenic effects of the algan toxins is reported.The cell strain used in this assay was derived from embryos of Syrian golden hamter and the algal toxins were extracted from Microcystis aeruginosa,termed microcystis raw toxic(MRT).To elucidate is prooting activity,the target cells were first exposed to a low dosage of 3-methylcholanthrene(MCA)and then to MRT.The results showed that MRT significantly enhanced the MCA-initiated cell transformation,and a dose-response reltionship was observed,but it failed to induce transformation of SHE cells not pretreated by MCA.These results suggest that the MRT play an important role in the malignant transformation of SHE cells.MRT may thus be a tumor promoter,and this transformation assay with SHE cells may be used to predict tumor prompting activity of environmental chemicals before long-term in vivo two-stage carcinogenesis experiments are carried out. 相似文献
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