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排序方式: 共有392条查询结果,搜索用时 17 毫秒
1.
目的:探讨17α-羟化酶缺乏症患者治疗方案的制订与药学监护。 方法:回顾性分析临床药师参与的1例17α-羟化酶缺乏症患者治疗过程,主要从优化糖皮质激素替代治疗、降压药物选择以及性激素补充方案制定方向讨论该疾病患者药学监护思路及策略,对患者进行用药指导和随访。结果:患者血钾水平恢复正常,血压控制稳定,择期进行隐睾切除手术,住院期间未出现明显不良反应。结论:临床药师可协助医师制订及优化患者糖皮质激素和降压治疗方案制定,完成药学监护,促进17α-羟化酶患者及时、高效的药物治疗。  相似文献   
2.
Ma  Xujing  Lu  Fengmei  Hu  Caihong  Wang  Jiao  Zhang  Sheng  Zhang  Shuqin  Yang  Guiran  Zhang  Jiuquan 《Brain imaging and behavior》2021,15(4):2101-2108

Amyotrophic lateral sclerosis (ALS) is a multi-system disease featured by movement disorder. Studies on ALS using static neuroimaging indexes demonstrated inconsistent results. However, recent work indicated that the intrinsic brain activity was time-varying, and the abnormal temporal dynamics of brain activity in ALS remains unknown. Resting-state functional magnetic resonance imaging data were first obtained from 54 patients with ALS and 54 healthy controls (HCs). Then the dynamic regional homogeneity (d-ReHo) was calculated and compared between the two groups. Correlation analyses between altered d-ReHo and clinical scores were further performed. Compared with HCs, ALS patients showed higher d-ReHo in the left lingual gyrus while lower d-ReHo in the left rectus gyrus and left parahippocampal gyrus. Moreover, the d-ReHo in the left lingual gyrus exhibited correlation with disease progression rate in ALS at a trend level. Our findings suggested that altered dynamics in intrinsic brain activity might be a potential biomarker for diagnosing of ALS.

  相似文献   
3.
杨双  胡爱萍  向明芳 《中国全科医学》2022,25(31):3965-3970
亲密伴侣暴力(IPV)是指亲密伴侣之间发生的威胁或虐待行为,其具体形式包括身体、精神或性伤害。现有研究表明,IPV可给受害者带来一系列身体和心理上的损伤,严重影响受害者的生活质量。准确评估IPV是制定针对性预防措施的前提和基础。然而,国内对IPV的研究尚处于起步阶段,针对IPV的评估工具缺乏。本文将国外常用的8种IPV评估工具分为研究工具和筛查工具,对各工具的主要内容、应用情况及特点进行综述,并对这8种评估工具的优缺点进行比较,旨在为我国IPV相关研究提供借鉴,为准确评估和识别IPV受害者提供依据。  相似文献   
4.
Breast tumor segmentation is an important step in the diagnostic procedure of physicians and computer-aided diagnosis systems. We propose a two-step deep learning framework for breast tumor segmentation in breast ultrasound (BUS) images which requires only a few manual labels. The first step is breast anatomy decomposition handled by a semi-supervised semantic segmentation technique. The input BUS image is decomposed into four breast anatomical structures, namely fat, mammary gland, muscle and thorax layers. Fat and mammary gland layers are used as constrained region to reduce the search space for breast tumor segmentation. The second step is breast tumor segmentation performed in a weakly-supervised learning scenario where only image-level labels are available. Breast tumors are first recognized by a classification network and then segmented by the proposed class activation mapping and deep level set (CAM-DLS) method. For breast anatomy decomposition, the proposed framework achieves Dice similarity coefficient (DSC) of 83.0 ± 11.8%, 84.3 ± 10.0%, 80.7 ± 15.4% and 91.0 ± 11.4% for fat, mammary gland, muscle and thorax layers, respectively. For breast tumor recognition, the proposed framework achieves sensitivity of 95.8%, precision of 92.4%, specificity of 93.9%, accuracy of 94.8% and F1-score of 0.941. For breast tumor segmentation, the proposed framework achieves DSC of 77.3% and intersection-over-union (IoU) of 66.0%. In conclusion, the proposed framework could efficiently perform breast tumor recognition and segmentation simultaneously in a weakly-supervised setting with anatomical constraints.  相似文献   
5.
6.
采用量表方式对脑卒中患者进行运动功能评定,存在效率低、主观性强等不足。基于传感器技术和机器学习方法的脑卒中运动功能自动化评定,可针对脑卒中患者的运动控制、平衡、步态、关节活动度等运动功能进行自动化评定,开发了许多产品。  相似文献   
7.
Huang  Xinyue  Li  Lei  Ling  Zihan  Gao  Leying  Chen  Huafu  Duan  Xujun 《Brain imaging and behavior》2022,16(1):397-405
Brain Imaging and Behavior - Despite the fast growing interest in the impact of microbiome–gut–brain interaction on regulating emotional behavior in animals, the underlying mechanisms...  相似文献   
8.
《Vaccine》2015,33(27):3142-3149
To overcome the limiting antigenic repertoire of protein sub-units and the side effects of adjuvants applied in second generation vaccines, the present work combined in vitro and in vivo manipulations to develop biomaterials allowing natural antigen-loading and presentation in vitro and further activation of the immune response in vivo. 3-dimensional laser micro-textured implantable Si-scaffolds supported mouse macrophage adherence, allowed natural seeding with human serum albumin (antigen) and specific antibody and inflammatory cytokine production in vitro. Implantation of Si-scaffolds loaded with antigen-activated macrophages induced an inflammatory reaction along with antigen-specific antibody production in vivo, which could be detected even 30 days post implantation. Analysis of implant histology using scanning electron microscopy showed that Si-scaffolds could be stable for a 6-month period. Such technology leads to personalized implantable vaccines, opening novel areas of research and treatment.  相似文献   
9.
2019新型冠状病毒感染已严重威胁到人们的健康和生活,但目前尚无特效治疗药物对其进行有效的防控。大黄素作为蓼科植物大黄及虎杖的主要活性成分,具有广谱的抗病毒活性,对包括SARS冠状病毒(SARS-CoV)、流感病毒、HIV病毒、HBV病毒等的感染和复制具有抑制作用。因此,本文就抗SARS-CoV的中成药及中药复方、大黄素及复方制剂抗病毒的机制、含大黄及虎杖的复方制剂抗病毒的临床研究和大黄素用于治疗新型冠状病毒肺炎(COVID-19)的可能性进行综述,旨在探讨其治疗2019新型冠状病毒的临床可能性。  相似文献   
10.
In this study, the response of Pu2Zr2O7 and La2Zr2O7 to electronic radiation is simulated, employing an ab initio molecular dynamics method. It is shown that Pu2Zr2O7 undergoes a crystalline-to-amorphous structural transition with 0.3% electronic excitation, while for La2Zr2O7, the structural amorphization occurs with 1.2% electronic excitation. During the microstructural evolution, the anion disorder further drives cation disorder and eventually results in the structural amorphization of Pu2Zr2O7 and La2Zr2O7. The difference in responses to electron radiation between Pu2Zr2O7 and La2Zr2O7 mainly results from the strong correlation effects between Pu 5f electrons and the smaller band gap of Pu2Zr2O7. These results suggest that Pu2Zr2O7 is less resistant to amorphization under local ionization rates that produce a low level of electronic excitation, since the level of the concentration of excited electrons is relatively low in Pu2Zr2O7. The presented results will advance the understanding of the radiation damage effects of zirconate pyrochlores.  相似文献   
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