全文获取类型
收费全文 | 323篇 |
免费 | 38篇 |
国内免费 | 12篇 |
专业分类
儿科学 | 3篇 |
妇产科学 | 2篇 |
基础医学 | 12篇 |
口腔科学 | 1篇 |
临床医学 | 36篇 |
内科学 | 20篇 |
皮肤病学 | 1篇 |
神经病学 | 1篇 |
特种医学 | 29篇 |
外科学 | 23篇 |
综合类 | 44篇 |
预防医学 | 10篇 |
眼科学 | 5篇 |
药学 | 41篇 |
中国医学 | 136篇 |
肿瘤学 | 9篇 |
出版年
2023年 | 12篇 |
2022年 | 43篇 |
2021年 | 58篇 |
2020年 | 39篇 |
2019年 | 22篇 |
2018年 | 12篇 |
2017年 | 14篇 |
2016年 | 10篇 |
2015年 | 10篇 |
2014年 | 48篇 |
2013年 | 30篇 |
2012年 | 32篇 |
2011年 | 19篇 |
2010年 | 10篇 |
2009年 | 1篇 |
2008年 | 4篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 1篇 |
1993年 | 1篇 |
排序方式: 共有373条查询结果,搜索用时 15 毫秒
1.
《Explore (New York, N.Y.)》2022,18(4):402-410
BackgroundThe aim of the study was to evaluate the effect of Tai Chi on functional mobility, balance and falls in Parkinson's disease.Materials and methodsA comprehensive literature search was conducted to identify the systematic reviews and meta-analyses up to the end of October 2021. 601 studies were identified, and 16 of them were included in our study.ResultsAccording to our meta-analysis; there was a significant effect of Tai Chi on balance (SMD, ?0.777 95% CI ?0.921 to -0.633; p = 0.000), functional mobility (SMD, ?0.719 95% CI ?0.944 to -0.494; p = 0.000), and falls (SMD, ?0.456 95% CI ?0.668 to -0.245; p = 0.000) in PD.ConclusionOur systematic review and meta-analysis found significant effects of Tai Chi on functional mobility, balance and falls in patients with PD. 相似文献
2.
目前原发性干燥综合征(pSS)诊断仍然依赖于侵入性小涎腺活检手术,常导致其早期诊断异常艰难,因此筛选特定生物标志物可能对pSS诊断和个体化治疗极为有益。本文回顾传统标志物及与B细胞活化和表观遗传相关的新标志物,并综述组学标志物研究进展。尽管生物标志物前景较好,但其可靠性仍需扩大样本量进行验证。 相似文献
3.
《Journal of diabetes and its complications》2022,36(6):108201
AimsTo explore the impact of HBV infection on maternal and infant outcomes of GDM women.MethodsWe retrospectively identified 8126 women with GDM in China from July 2017 to June 2020, and divided them into GDM with HBV infection group (n = 483) and GDM with non-HBV infection group (n = 7643). Two sample t-test and Chi-square test were used to compare differences between groups. Logistic regression models were used to explore the association between HBV infection and maternal and infant outcomes.ResultsPlacental abruption (PA), (2.3% vs. 1.0%, P = 0.008), placenta previa (4.3% vs. 2.8% p = 0.044), intrahepatic cholestasis of pregnancy (ICP), (6.4% vs. 3.0%, P < 0.001), cesarean section (52.0% vs. 46.0%, P = 0.011), fetal chromosomal abnormalities (1.2% vs. 0.4%, P = 0.021), and neonatal hyperglycemia (1.9% vs. 3.6%, P = 0.047) were more likely to occur in GDM with HBV infection group. After adjusting for the covariates, HBV infection was found to be associated with ICP (aOR, 2.35; 95% CI: [1.58–3.50]), PA (aOR, 2.34; 95% CI: 1.22–4.47), and fetal chromosomal abnormalities (aOR, 2.88; 95% CI: 1.18–7.03).ConclusionsHBV infection was associated with part of maternal and infant outcomes in the GDM population. 相似文献
4.
目的:探讨五色培元固本膏对维持性血液透析(MHD)患者细胞免疫功能的影响。方法:90例MHD患者随机分为对照组和治疗组,两组血透方法相同。对照组给予一般治疗及血透治疗,治疗组在对照组基础上口服五色培元固本膏,连续治疗3个月; 20例健康志愿者作为正常组,三组观察时间均为3个月。治疗前后用流式细胞技术检测各组T细胞亚群表达水平,酶联免疫吸附法检测各组白介素-2(IL-2)和可溶性白介素-2受体(sIL-2R)蛋白表达水平。结果:治疗前与正常组比较,对照组与治疗组CD4+、CD4+/CD8+和IL-2表达水平均明显下降,CD8+和sIL-2表达水平均上升,差异有统计学意义(P<0.05)。治疗后,与对照组相比较,治疗组CD4+、CD4+/CD8+、IL-2表达水平明显升高,CD8+和sIL-2表达水平均降低,差异有统计学意义(P<0.05)。治疗组相较正常组CD4+T淋巴细胞、CD4+/CD8+、IL-2表达水平,差异无统计学意义(P>0.05),CD8+、sIL-2表达水平升高。结论:五色培元固本膏调节T淋巴细胞和IL-2表达改善MHD的细胞免疫功能。 相似文献
5.
王辉武教授临床观察认为“湿邪”可能与现代医学所说的“病毒”相类似,中医中药以祛风除湿、芳香化湿、苦温燥湿、淡渗利湿、健脾驱湿等治疗病毒性疾病均有明显疗效,可见“湿”为治疗核心,故大胆提出“湿为病毒”学术观点,并进行了多年的理念论证和临床验证。本文运用中医湿邪理论,探讨论证病毒性疾病与湿邪的相关性,希望有益于病毒性疾病的辨识,便于对疾病的早期干预,防止进一步恶化,以求丰富中医防治病毒性疾病的理念。 相似文献
6.
《Explore (New York, N.Y.)》2022,18(4):457-462
ObjectiveThe literature describes many techniques to increase vein visibility and palpability that facilitate peripheral intravenous catheter insertion. However, there is only one study examining the effect of topical essential black pepper oil on veins. We aimed to determine the effects of topical application of black pepper essential oil on peripheral intravenous catheter insertion success.MethodsThis randomized controlled trial was carried out on 60 patients randomly assigned to either the experimental group (n=30) or the control group (n=30) reporting to the endoscopy unit of the clinic between May 2019 and October 2019. The study results were evaluated using an information form, a catheter insertion form, and a visual analog scale (VAS). In the experimental group, black pepper essential oil was used to increase vein degree before the procedure, while in the control group, no extra interventions were applied. The time taken in determining an appropriate vein, time taken for successful catheter insertion, and the patient's and nurse's satisfaction after the process were recorded.ResultsSignificant improvements in vein degree were detected after the experimental group's oil application (p1<0.001). The period of appropriate vein selection and successful catheter insertion showed a statistically significant decrease in the experimental group (p<0.05). The satisfaction levels of patients and nurses in the control group were significantly lower than those of the patients from the experimental group (p<0.05).ConclusionTopical black pepper oil application can increase the vein degree and the success of the procedure. 相似文献
7.
目的分析比较一次性根治术与切开挂线术对腺源性肛瘘患者的疗效。方法将重庆医科大学附属第一医院收治的88例腺源性肛瘘患者随机分为一次性根治术组(DRO组)和切开挂线术组(ITD组),各44例,DRO组给予一次性根治术治疗,ITD组给予切开挂线术治疗。对比两组患者住院时间,应用视觉模拟评分法(VAS)评估术后6 h、12 h、24 h、48 h患者的疼痛程度,并比较伤口愈合时间、术后2周时的排便功能恢复情况,另统计并对比两组患者手术治愈率及术后并发症及复发情况。结果DRO组住院时间及伤口愈合时间均明显长于ITD组(P<0.05)。经重复测量方差分析,VAS评分差异有统计学意义(P<0.05);两组组内术后48 h VAS评分<术后24 h<术后12 h<术后6 h,差异均有统计学意义(P<0.05);DRO组术后6 h、12 h、24 h、48 h VAS评分均显著低于ITD组(P<0.05)。术后2周时两组排便功能恢复情况等级分布差异显著(P<0.05)。两组治愈情况等级分布差异不显著(P>0.05)。术后两组总并发症发生率无显著差异(P>0.05)。随访1年,DRO组复发率为2.27%,显著低于ITD组的18.18%(P<0.05)。结论在腺源性肛瘘患者的治疗中,一次性根治术与切开挂线术的治愈率相当,术后并发症少,一次性根治术能够减轻患者术后疼痛,促进排便功能恢复,降低复发率,切开挂线术能够缩短住院时间,加快伤口愈合。 相似文献
8.
目的研究转录因子21(TCF21)在卵巢癌细胞株中的表达及其对卵巢癌细胞株HEY恶性生物学行为的影响。方法通过实时荧光定量聚合酶链反应(qRT-PCR)和免疫组织化学检测TCF21在正常卵巢组织、卵巢癌细胞株和高级别浆液性卵巢癌组织中的差异表达,采用qRT-PCR检测药物性去甲基化后TCF21的表达水平。在低表达TCF21的HEY卵巢癌细胞株中过表达TCF21,通过平板克隆试验检测细胞的增殖,建立裸鼠皮下种植瘤模型,观察裸鼠体内成瘤能力。通过Transwell试验检测过表达TCF21后对卵巢癌细胞HEY迁移、侵袭能力的影响。结果TCF21甲基化使其在卵巢癌细胞中的蛋白及mRNA表达明显低于正常卵巢细胞和组织,外源性过表达TCF21可抑制HEY细胞克隆形成率和成瘤能力,明显降低肿瘤细胞的迁移、侵袭能力。结论TCF21过表达可抑制卵巢癌细胞恶性生物学行为。 相似文献
9.
目的:观察"三神针"对中风后失眠患者睡眠质量的改善情况及其对血清褪黑素(melatonin,MT)和5-羟色胺(5-hydroxytryptamine,5-HT)的影响。方法:将70例中风后失眠患者随机分为试验组和对照组各35例。对所有患者予以基础治疗及恢复治疗。治疗组采用"三神针"为主进行治疗,对照组采用普通针刺治疗。每天1次,每周治疗5次,每次留针30 min,2周为1个疗程,共治疗2个疗程。对所有病例治疗前后进行匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)、失眠严重指数量表(insomnia severity index,ISI)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分及MT、5-HT含量对比,并对治疗过程中遇到的不良事件进行记录。结果:两组PSQI各因子及总分比较,差异有统计学意义(P<0.05);两组ISI评分比较,差异有统计学意义(P<0.05);两组HAMA、HAMD评分比较,差异有统计学意义(P<0.05);试验组有效率97.14%(34/35),对照组有效率82.86%(29/35),两组比较,差异有统计学意义(P<0.05);两组均未出现明显不良反应。结论:"三神针"选穴合理精妙,临床疗效确切,能显著改善中风后失眠患者的PSQI评分、HAMD评分、HAMA评分、ISI评分,改善患者的不适症状,是一种疗效好、痛苦小、易接受的治疗方案。 相似文献
10.