首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   7篇
  完全免费   3篇
  中国医学   10篇
  2017年   1篇
  2014年   4篇
  2013年   4篇
  2010年   1篇
排序方式: 共有10条查询结果,搜索用时 78 毫秒
1
1.
2.

Ethnopharmacological relevance

Canna indica L. (CI) has been widely used as a folklore medicine in tropical and subtropical areas with beneficial effects in numerous diseases, including infection, rheumatism, hepatitis, and it has also been identified as an antioxidant.

Materials and methods

The present study aimed to investigate the effect of Canna indica CI ethanolic extract (CIE) on productions of nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1β (IL-1β) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. In addition, the effects of CIE in high glucose (HG)-induced U937 monocytes on mRNA expressions of IL-8 and monocyte chemoattractant protein-1 (MCP-1), and regulation of mitogen-activated protein kinase (MAPK) pathways were also identified.

Results

CIE was found to inhibit the production of inflammatory mediators including NO, IL-1β, and PGE2 from LPS-induced RAW 264.7 macrophages. The increases in HG-induced mRNA expressions of IL-8 and MCP-1 were also significantly inhibited by CIE. Stimulation of HG in U937 monocytes resulted in activation of p38 MAPK, ERK1/2, and JNK. However, CIE treatment significantly decreased phosphorylation of p38 MAPK, ERK1/2, and JNK.

Conclusion

The present study demonstrated that CIE suppressed the LPS-induced inflammatory mediator production and also inhibited HG-induced inflammatory mediator expression by the regulation of MAPK pathway.  相似文献
3.

Ethnopharmacological relevance

The fruits of Hippophae rhamnoides L., Lycium barbarum L., Lycium ruthenicum Murr. and Nitraria tangutorum Bobr. are traditional medicinal food of Tibetans and used to alleviate fatigue caused by oxygen deficiency for thousands of years. The present study focused on exploiting natural polysaccharides with remarkable anti-fatigue activity from the four Qinghai-Tibet plateau characteristic berries.

Materials and methods

The fruits of Hippophae rhamnoides, Lycium barbarum, Lycium ruthenicum and Nitraria tangutorum were collected from Haixi national municipality of Mongol and Tibetan (N 36.32°, E98.11°; altitude: 3100 m), Qinghai, China. Their polysaccharides (HRWP, LBWP, LRWP and NTWP) were isolated by hot-water extraction, and purified by DEAE-Cellulose ion-exchange chromatography. The total carbohydrate, uronic acid, protein and starch contents of polysaccharides were determined by a spectrophotometric method. The molecular weight distributions of polysaccharides were determined by gel filtration chromatography. Their monosaccharide composition analysis was performed by the method of 1-phenyl-3-methyl-5-pyrazolone (PMP) pre-column derivatization and RP-HPLC analysis. HRWP, LBWP, LRWP and NTWP (50, 100 and 200 mg/kg) were orally administrated to mice once daily for 15 days, respectively. Anti-fatigue activity was assessed using the forced swim test (FST), and serum biochemical parameters were determined by an autoanalyzer and commercially available kits; the body and organs were also weighted.

Result

LBWP, LRWP and NTWP were mainly composed of glucans and some RG-I pectins, and HRWP was mainly composed of HG-type pectin and some glucans. All the four polysaccharides decreased immobility in the FST, and the effects of LBWP and NTWP were demonstrated in lower doses compared with HRWP and LRWP. There was no significant difference in liver and heart indices between non-treated and polysaccharide-treated mice, but the spleen indices were increased in LBWP and NTWP (200 mg/kg) group. Moreover, the FST-induced reduction in glucose (Glc), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and increase in creatine phosphokinase (CK), lactic dehydrogenase (LDH), blood urea nitrogen (BUN), triglyceride (TG) and malondialdehyde (MDA) levels, all indicators of fatigue, were inhibited by HRWP, LBWP, LRWP and NTWP to a certain extent while the effects of LBWP and NTWP were much better than that of HRWP and LRWP at the same dosage.

Conclusion

Water-soluble polysaccharides HRWP, LBWP, LRWP and NTWP, from the fruits of four Tibetan plateau indigenous berry plants, significantly exhibited anti-fatigue activities for the first time, through triglyceride (TG) (or fat) mobilization during exercise and protecting corpuscular membrane by prevention of lipid oxidation via modifying several enzyme activities. Moreover, it is demonstrated that LBWP and NTWP are more potent than HRWP and LRWP, which were proposed to be applied in functional foods for anti-fatigue and antioxidant potential.  相似文献
4.

Ethnopharmacological relevance

Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Labiatae, Danshen in Chinese) and Flos Carthami (Carthamus tinctorius L., Compositae, Honghua in Chinese), has been reported to have anti-inflammatory, anti-oxidative and anti-fibrinolytic properties, which is used extensively for the treatment of cardiovascular diseases in clinic.

Aim of this study

The present study aimed to investigate the preventive and therapeutic effects of DHI on lipopolysaccharide (LPS) induced acute lung injury (ALI) in mice.

Materials and methods

Lung injury was induced by intranasal instillation with 10 μg LPS. Mice were randomly divided into four groups:Control group; LPS group; LPS+5 ml/kg DHI group and LPS+10 ml/kg DHI group. The effects of DHI on LPS-induced neutrophils influx, inflammatory cytokines release, protein leakage, myeloperoxidase (MPO) and superoxide dismutase (SOD) activities, malondialdehyde (MDA) level were examined. In addition, the NF-κB activation in lung tissues was detected by Western blot.

Results

In LPS challenged mice, DHI significantly reduced the infiltration of activated neutrophils and decreased the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid (BALF). DHI also inhibited protein extravasation in BALF, attenuated edema and the pathological changes in the lung. In addition, DHI markedly prevented LPS-induced elevation of MDA and MPO levels, as well as reduction of SOD activity. Further study demonstrated that DHI effectively inhibited the NF-κB activation in lung tissues.

Conclusion

DHI has been demonstrated to protect mice from LPS induced acute lung injury by its anti-inflammatory and anti-oxidant activities.  相似文献
5.
目的探究小剂量阿司匹林联合美托洛尔治疗老年慢性心衰的临床疗效。方法选取2011年7月-2013年7月总后勤部广州离职干部休养所门诊部就诊的老年慢性心衰患者84例,依据分层随机分组方法将患者分为治疗组与对照组,每组42例,治疗组口服小剂量阿司匹林肠溶片,75mg/次,1次/d;同时,口服酒石酸美托洛尔6.25mg/次,2次/d,配合常规抗心衰治疗。对照组仅予以常规抗心衰治疗,两组均治疗4周。观察两组患者治疗前后血浆P.选择素、血管性假性血友病因子、D-二聚体水平、脑利钠肽水平及心功能改善情况。结果治疗4周后,两组患者血浆P.选择素、血管性假性血友病因子和D-二聚体水平均较治疗前有所下降,治疗前后差异均有统计学意义(P〈0.05);治疗后治疗组患者的血浆P-选择素、血管性假性血友病因子和D-二聚体水平均低于对照组,两组差异有统计学意义(P〈0.05)。治疗1、2、3、4周后,两组患者脑利钠肽水平均较治疗前有所下降,治疗前后差异均有统计学意义(尸〈0.05)。治疗后,治疗组患者的脑利钠肽水平均低于同期对照组患者,两组差异有统计学意义(P〈0.05)。治疗后,治疗组和对照组的总有效率分别为85.71%、57.14%,两组比较差异有统计学意义(P〈0.05)。结论d,N量阿司匹林联合美托洛尔配合标准抗心衰治疗对于老年慢性心衰患者具有较好的抗血栓形成和促进患者心功能恢复的作用,建议临床推广使用。  相似文献
6.
目的研究高血压病颈动脉硬化(carotid atherosclerosis,CAS)痰湿证患者左室重构的变化。方法观察高血压病CAS患者223例(痰湿证组119例、非痰湿证组104例,高血压病CAS组)、非高血压病CAS患者81例(非高血压病CAS组)和非高血压非CAS患者19例(对照组)的心脏多普勒超声检查结果,比较各组发生左室重构程度的差异。结果高血压病CAS组的左室后壁厚度(left ventricular posterior wall thickness,LVPWT)、舒张末期室间隔厚度(inter ventricular septum thickness,IVS)、二尖瓣快速充盈期与心房收缩期血流速度比值(E/A)高于非高血压病CAS组(P〈0.05)。高血压病软斑组及非高血压病软斑组的左室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)、左室收缩末期内径(left ventricular end-systolic diameter,LVESD)、每搏出量(stroke volume,SV)高于硬斑组、内膜增厚组和内膜正常组,差异有统计学意义(P〈0.01,P〈0.05)。高血压病痰湿证组的LVEDD、LVESD、SV高于高血压病非痰湿证组(P〈0.05),左室射血分数(ejection fraction,EF)低于高血压病非痰湿证组(P〈0.05),其中软斑组的LVEDD、LVESD、SV高于硬斑组(P〈0.01)、内膜增厚组(P〈0.01)和内膜正常组(P〈0.05)。高血压病非痰湿证软斑组与硬斑组的比较差异无统计学意义(P〉0.05)。结论高血压病痰湿证患者的CAS可能与左室重构有关,特别是软斑组患者,其左室重构更为明显。  相似文献
7.
目的评价降脂通络软胶囊联合阿托伐他汀钙片与单用阿托伐他汀钙片治疗混合型高脂血症的有效性和安全性。方法本研究采用随机、双盲、平行对照、多中心临床研究设计。采用随机数字表法将1 38例混合型高脂血症患者分为联合用药组与单用他汀组,每组69例,两组患者均给予阿托伐他汀钙片口服,20 mg/天。联合用药组在此基础上,予降脂通络软胶囊口服,1 00 mg/次,每天3次;单用他汀组予降脂通络软胶囊模拟剂口服治疗,1 00 mg/次,每天3次,疗程均为8周。分别于治疗前、治疗4、8周检测两组患者TG、TC、LDL-C、HDL-C水平,并对治疗安全性进行评价。结果与治疗前比较,治疗4、8周后联合用药组血清TG分别下降26.69%、33.29%(均P〈0.01),单用他汀组TG分别下降25.70%、22.98%(均P〈0.01)。治疗8周后,联合用药组TG下降值明显高于单用他汀组(P〈0.05)。与治疗前比较,治疗4、8周后两组患者血清LDL-C、TC水平显著降低(均P〈0.01),两组LDL-C、TC下降值及下降率比较,差异无统计学意义(P〉0.05)。治疗8周后两组HDL-C均有升高趋势。两组治疗后均未出现肝酶和肌酸激酶明显升高。结论降脂通络软胶囊联合阿托伐他汀钙片治疗混合型高脂血症可明显降低患者血清TG水平,且安全性较好。  相似文献
8.

Background

To scientifically test a traditionally belief of some Asian countries residents that opium may prevent or have ameliorating effects on cardiovascular diseases (CVD) we investigated the effect of passive opium smoking (POS) on plasma lipids and some cardiovascular parameters in hypercholesterolemic rabbits with ischemic and non-ischemic hearts.

Methods

40 rabbits were fed for 2 weeks with cholesterol-enriched diet and divided to control (CTL), short-term opium (SO) and long-term opium (LO) groups. SO and LO groups were exposed to POS for 3 days and 4 weeks respectively. ECG, blood pressure (BP) and left ventricular pressure recorded and serum lipid and cardiac troponin I levels were measured. Isoproterenol (ISO) injected for induction of cardiac ischemia and after 4 h the above variables were measured along with cardiac histopathology assessment.

Results

HDL cholesterol decreased significantly in LO compared to CTL group (35 ± 5 vs 53 ± 5 mg/dl). Groups treated with ISO showed significantly higher increments in troponin I level (P < 0.05) except for LO group and reduction of BP was higher in ISO and SO + ISO groups compared to CTL and SO groups respectively (−38 ± 6 vs −23 ± 4 and −37 ± 11 vs −11 ± 3 percent respectively, P < 0.05). Reduction in BP was significantly lower in LO + ISO compared to ISO group. Opium exposure caused a trend of increase in blood pressure, LDL cholesterol and ECG disturbances, attenuated ISO induced myonecrosis but augmented tissue congestion and hemorrhage.

Conclusion

POS can be considered as a CVD risk factor. Opium does not reduce BP or cholesterol level, as is anticipated by its users.  相似文献
9.
10.
Pomegranate (Punica granatum L.) juice (PJ) contains different types of antioxidants and bioactive polyphenols and has been reported to promote cardiovascular health through several mechanisms. The present study aimed to examine the effects of 2‐week intake of fresh PJ on blood pressure, flow‐mediated dilatation (FMD), serum lipid profile and concentrations of inflammatory and endothelial function biomarkers. Twenty‐one hypertensive patients (aged 30–67 years) were recruited into the trial and assigned to receive either PJ (150 ml/day in a single occasion between lunch and dinner; n = 11) or the same amount of water (n = 10) for a period of 2 weeks. Systolic (SBP) and diastolic (DBP) pressures together with FMD and serum concentrations of lipid profile parameters, apolipoproteins A and B, intracellular adhesion molecule‐1 (ICAM‐1), vascular endothelial adhesion molecule 1 (VCAM‐1), E‐selectin, high‐sensitivity C‐reactive protein (hs‐CRP) and interleukin‐6 (IL‐6) were measured at baseline and at the end of trial. PJ consumption was associated with significant reductions in SBP (p = 0.002) and DBP (p = 0.038) but not FMD (p > 0.05). Serum levels of VCAM‐1 (p = 0.008) were significantly reduced by PJ while those of E‐selectin were elevated (p = 0.039). However, no significant effect was observed from PJ on serum levels of ICAM‐1, hs‐CRP, lipid profile parameters, apolipoproteins and IL‐6 in any of the study groups (p > 0.05). Consumption of PJ for 2 weeks has effective hypotensive effects, and may improve endothelial function by decreasing serum concentrations of VCAM‐1. These findings suggest PJ as a beneficial cardioprotective supplement for hypertensive subjects. Copyright © 2013 John Wiley & Sons, Ltd.  相似文献
1
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号