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Clinical Rheumatology - Coronavirus disease-19 (COVID-19) is a global pandemic that is caused by COVID-19 virus, which was initially identified in December 2019 in Wuhan, China. Vaccination is one...  相似文献   
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International Ophthalmology - To determine the frequency and risk factors of narrow angles in pseudoexfoliation (PXF) patients. A prospective case–control study was conducted during the...  相似文献   
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BackgroundInclusion Health aims to address and prevent the health harms of extreme inequity faced by excluded groups, including those affected by homelessness, drug addiction, imprisonment, and sex work. Engagement workshops with these groups have shown discordance between published research and what research they think is important. We aimed to involve these excluded groups and the wider service, policy, charity, and academic community who work with them to co-develop research and advocacy priorities.MethodsUsing a co-production approach, we held a 1-day event in London, UK, that involved inclusive, participatory, and consensus-building activities. We facilitated workshops on preventing exclusion, improving services for excluded groups, and escaping exclusion. We recorded participants’ views as observations, field notes, and ranked-lists of problems and suggested solutions. Professional artists captured frustrations and hopes for the future by drawing a visual representation. We conducted rapid thematic analysis of discussions on the day and triangulated these sources of information to develop research and advocacy priorities.FindingsApproximately 100 people attended, with at least 20 people with experience of exclusion. The other participants represented the National Health Service, various charity organisations, national, regional, and local government representatives, and several academic institutions. Emerging priorities included the following: tackling the upstream causes of exclusion (political determinants, poverty, and traumatic childhoods); addressing public and professional ignorance, indifference, and stigma by creating inclusion-focused public messages; making services more accessible and integrated through infrastructure (eg, national registries of services); putting excluded groups at the heart of health research, service development, and decision making, through the development of training for recruitment and co-design; and creating better routes out of exclusion.InterpretationDespite challenges in finding a common language, co-production effectively developed an Inclusion Health agenda aligned with the perceived needs of excluded groups and those who work with them. Funding agencies and the public health community should deliver this research agenda to improve the health and lives of people affected by exclusion.FundingUniversity College London Grand Challenges.  相似文献   
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This study investigated the effect of testosterone deficiency and replacement on platelets function and aggregation, coagulation, and fibrinolysis in young adult healthy male rats. Rats were classified into three groups (n = 6/group) of either “a sham-operated+ vehicle,” “an orchidectomized (ORX)+ vehicle,” and “an ORX+testosterone propionate (0.5 mg/kg, 3X/week, S.C).” All treatments were carried out for 12 weeks. Our results showed that ORX rats had induced platelets aggregation and coagulation and inhibited fibrinolysis. ORX-induced rats had increased ratios of adenosine diphosphate-induced aggregation, shorter bleeding time, clotting time, prothrombin time, and activated partial thromboplastin time and their sera showed increased levels of thromboxane B2 and fibrinogen levels. Concomitantly, their plasma showed increased TPA-1 and decreased tissue plasminogen activator (tPA) levels. At molecular levels, the aorta of ORX-induced rats showed increased aortic mRNA and protein levels of plasminogen activator inhibitor-1 (PAI-1), protein levels of von Willebrand Factor (vWF) and decreased mRNA and protein levels of tPA, and their liver showed increased protein levels of prothrombin and factor VII. Testosterone post-therapy to ORX-induced rats significantly reversed all these hematological and molecular changes. In conclusion, independent of any other risk factors, testosterone deficiency induces platelets aggregation and hypercoagulation and inhibits fibrinolysis, effects that can be reversed by testosterone therapy.  相似文献   
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Abstract

Data on eating disorders in women with PCOS is insufficient. The objective of this case study was to examine the hypothesis that women with PCOS exhibit more impaired eating than healthy women. Women diagnosed with PCOS under the 2003 Rotterdam Diagnostic Criteria (n?=?40) were compared with a healthy control group (n?=?40). The groups also were divided into two as normal body weight and overweight/obese. The Eating Disorders Assessment Questionnaire (EDE-Q) and the Three Factor Eating Questionnaire (TFEQ-R21), were completed by all participants in order to evaluate eating behaviors in addition to eating disorders. Among the overweight/obese group, the average total and subscale scores of the EDE-Q as well as the total and sub-factor scores of the TFEQ-R21 were higher in women with PCOS compared to controls (p?<?.05). However, this statistically significant result was not shown among the women with normal weight (p?>?.05). In comparison to the controls, the PCOS women displayed higher values of the tool scores indicating abnormal restraint eating, body shape concern and weight concern subscale scores (p?<?.05). This result suggests that the evaluation of eating disorders should be added to routine screening and the monitoring of women with PCOS.  相似文献   
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