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甲状腺非典型腺瘤生物学特性及免疫组化研究 总被引:2,自引:0,他引:2
目的 :探讨甲状腺非典型腺瘤免疫组化表型与生物学特性的关系。方法 :采用免疫组化S P法 ,检测bcl 2、p5 3、PCNA的表达 ,并与单纯腺瘤和滤泡状癌对照研究。结果 :非典型腺瘤bcl 2、p5 3、PCNA阳性表达率分别为 82 8% (2 3/ 2 8)、2 5 % (7/2 8)、76 5 % (2 1/ 2 8) ,与腺瘤差异有显著性 (P <0 0 1) ,与滤泡状腺癌差异无显著性 (P >0 0 5 )。结论 :甲状腺非典型腺瘤似原位癌 ,手术治疗效果良好 ,罕见复发 ,无转移 相似文献
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Objective This study was conducted to evaluate the effects of postoperative glutamine and growth hormone on the nutritional status,immune function,and inflammatory responses of patients undergo-ing portal hypertension surgery.Methods This study was designed as a prospective,randomized and con-trolled clinical trial.Forty-two patients undergoing portal hypertension surgery were randomly divided into 2 groups:experimental group (receiving an immune enhancing parenteral nutrition by adding glutamine and re-combinant human growth hormone,n = 22),and control group (receiving an isocaloric and isonitrogenons standard parenteral nutrition,n = 20).Parenteral nutrition providing 125 kJ · kg-1·d-1 was initiated 3 days after surgery in both groups and last for 7 days.Blood samples were obtained on day 0th,3rd,and 10th.Host nutritional status was evaluated by measuring levels of prealbumin and transferrin,immunity was evalu-ated by measuring levels of CD4,CD8,CD4/CD8,IgG,IgM and IgA,and the inflanunatory responses was determined by assessing IL-2,TNF-α and C-reactive protein (CRP) levels.Results Ten days after opera-tion,among patients receiving an immune enhancing parenteral nutrition,the serum prealbumin was (193.84±39.78)mg/L,transferrin was (2.07±0.51)mg/L,CD4 was (33.7±5.5)%,CD4/CD8 was (1.17±0.32),IgG was (13.94±1.09)g/L and IL-2 was (368.12±59.25) pg/mL.They were signifi-cantly higher than those of the control group (P < 0.05).The TNF-α concentrations was (321.12±81.42)pg/mL and CRP was (32.2±15.2)mg/mL which were significantly lower than those of the control group (P < 0.05).Conclusion Postoperative administration of immune enhancing parentearl nutrition in patients undergoing portal hypertension surgery can improve nutritional status and immune function,and modulate inflammatory response is also better than standard one. 相似文献
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Objective This study was conducted to evaluate the effects of postoperative glutamine and growth hormone on the nutritional status,immune function,and inflammatory responses of patients undergo-ing portal hypertension surgery.Methods This study was designed as a prospective,randomized and con-trolled clinical trial.Forty-two patients undergoing portal hypertension surgery were randomly divided into 2 groups:experimental group (receiving an immune enhancing parenteral nutrition by adding glutamine and re-combinant human growth hormone,n = 22),and control group (receiving an isocaloric and isonitrogenons standard parenteral nutrition,n = 20).Parenteral nutrition providing 125 kJ · kg-1·d-1 was initiated 3 days after surgery in both groups and last for 7 days.Blood samples were obtained on day 0th,3rd,and 10th.Host nutritional status was evaluated by measuring levels of prealbumin and transferrin,immunity was evalu-ated by measuring levels of CD4,CD8,CD4/CD8,IgG,IgM and IgA,and the inflanunatory responses was determined by assessing IL-2,TNF-α and C-reactive protein (CRP) levels.Results Ten days after opera-tion,among patients receiving an immune enhancing parenteral nutrition,the serum prealbumin was (193.84±39.78)mg/L,transferrin was (2.07±0.51)mg/L,CD4 was (33.7±5.5)%,CD4/CD8 was (1.17±0.32),IgG was (13.94±1.09)g/L and IL-2 was (368.12±59.25) pg/mL.They were signifi-cantly higher than those of the control group (P < 0.05).The TNF-α concentrations was (321.12±81.42)pg/mL and CRP was (32.2±15.2)mg/mL which were significantly lower than those of the control group (P < 0.05).Conclusion Postoperative administration of immune enhancing parentearl nutrition in patients undergoing portal hypertension surgery can improve nutritional status and immune function,and modulate inflammatory response is also better than standard one. 相似文献
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为了解断流与分流两种手术后门静脉高压性胃病的胃粘膜变化,笔者将1994-01~1997-06住院107例肝硬变门静脉高压症中的36例门静脉高压性胃病患者随机分为断流术组20例与分流术组16例,胃镜观察手术前后胃粘膜损害的变化情况。结果表明,断流组术后胃粘膜病变程度较术前加重(P<005),而分流组则明显改善(P<005),但后者对肝功能的损害较前者的明显。 相似文献
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Objective This study was conducted to evaluate the effects of postoperative glutamine and growth hormone on the nutritional status,immune function,and inflammatory responses of patients undergo-ing portal hypertension surgery.Methods This study was designed as a prospective,randomized and con-trolled clinical trial.Forty-two patients undergoing portal hypertension surgery were randomly divided into 2 groups:experimental group (receiving an immune enhancing parenteral nutrition by adding glutamine and re-combinant human growth hormone,n = 22),and control group (receiving an isocaloric and isonitrogenons standard parenteral nutrition,n = 20).Parenteral nutrition providing 125 kJ · kg-1·d-1 was initiated 3 days after surgery in both groups and last for 7 days.Blood samples were obtained on day 0th,3rd,and 10th.Host nutritional status was evaluated by measuring levels of prealbumin and transferrin,immunity was evalu-ated by measuring levels of CD4,CD8,CD4/CD8,IgG,IgM and IgA,and the inflanunatory responses was determined by assessing IL-2,TNF-α and C-reactive protein (CRP) levels.Results Ten days after opera-tion,among patients receiving an immune enhancing parenteral nutrition,the serum prealbumin was (193.84±39.78)mg/L,transferrin was (2.07±0.51)mg/L,CD4 was (33.7±5.5)%,CD4/CD8 was (1.17±0.32),IgG was (13.94±1.09)g/L and IL-2 was (368.12±59.25) pg/mL.They were signifi-cantly higher than those of the control group (P < 0.05).The TNF-α concentrations was (321.12±81.42)pg/mL and CRP was (32.2±15.2)mg/mL which were significantly lower than those of the control group (P < 0.05).Conclusion Postoperative administration of immune enhancing parentearl nutrition in patients undergoing portal hypertension surgery can improve nutritional status and immune function,and modulate inflammatory response is also better than standard one. 相似文献
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目的:观察甲状腺非典型腺瘤的病理学特点,分型及免疫学表型。方法:HE染色光镜观察组织学特点并分型,免疫组化(S-P法)检测bcl-2,p53,PCNA表型,结果:225例巨检分为:孤立型168例,占75%,多结节型52例,占23%,隐匿型5例,占2%,光镜下组织学分为:腺泡状型180例,占80%,弥漫型34例,占15%,小梁状型11例,占5%,细胞形状学以下不规则型为主,占55%(124/225),梭形细胞型占30%(67/225),透明细胞型占10%(23/225),畸异细胞型占5%(11/225),免疫组化bcl-2,p53,PCNA在腺泡状,弥漫型,小梁 型中的阳性表达率分别为82.8%,24.5%,75.3%,81.4%,23.5%,76.5%,83.5%,25.1%,76.0%。三组间无显著差异(P>0.05),与滤泡状腺瘤比较有显著差异(P<0.01),与滤泡状癌比较无显著差异(P>0.05),结论:甲状腺非典型腺瘤组织学和细胞学均分为三型,生物学行为系原位癌。 相似文献
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目的 评价谷氨酰胺和生长激素对肝硬化门静脉高压症手术患者术后营养、免疫状态和急性炎症反应的影响.方法 选择42例接受门静脉高压症手术的肝硬化患者,随机分为两组:添加谷氨酰胺和人重组生长激素组(实验组,n=22)和标准营养组(对照组,n=20),两组术后第3天开始进行等氮等热最(125 kJ·kg-1·d-1)营养支持,持续7 d.手术当天(0 d)、第3和第10天清晨分别抽取静脉血,检测血清前白蛋白、转铁蛋白、T细胞亚群CD4、CD8、CD4/CD8、IgG、IgA、IgM、IL-2、TNF-α和CRP.结果 实验组在术后第10天血清前白蛋白:(193.84±39.78)mg/L、转铁蛋白:(2.07±0.51)mg/L、CD4:(33.7±5.5)%、CD4/CD8:(1.17±0.32)、IgG:(13.94±1.09)g/L和IL-2:(368.12±59.25)pg/mL均显著高于对照组(P<0.05),TNF-α:(321.12±81.42)pg/mL和CRP:(32.2±15.2)mg/mL均显著低于对照组(P<0.05).结论 谷氨酰胺和生长激素能够改善门静脉高压症患者手术后营养状态和免疫功能,调节急性炎症反应,作用优于标准胃肠外营养. 相似文献
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