阿片类依赖者事件相关电位的变化

药物成瘾是一种慢性和反复发作的脑病,以神经生理功能紊乱及病态行为如强制性的药物使用及持久的心理渴求为特征[1].近来,事件相关电位(event related potential,ERPs)越来越被广泛地用于评估有认知损害的疾病群体的认知功能状况.本文从ERPs的生理机制、起源、其与认知功能的关系及阿片类依赖者ERPs的变化作一简述,以期能为同道提供某些参考.     

病毒性心肌炎及扩张型心肌病患者心内膜心肌活检标本中免疫球蛋白的检测

对病理学确诊的25例病毒性心肌炎（VMC）和10例扩张型心肌病（DCM）患者心内膜心肌活检标本，运用ABC技术，进行了免疫球蛋白IgG、IgM、IgA和补体C3的检测。结果：20例VMC和9例DCM的标本中，发现了IgG和IgM的沉积，主要分布于心肌肌膜和毛细血管内皮，IgG的肌膜沉积与同步做的病理切片中观察到的心肌细胞坏死和炎性细胞浸润有病理形态学联系。两组患者中均未发现IgA和C3沉积。结果显示，IgG是参与VMC和DCM心肌损伤的主要免疫球蛋白，心肌病变与抗体诱导的免疫反应有关。     

聚对苯撑乙炔的合成及光谱性能-共轭主链被间位苯环阻隔

报道了一种阻隔型聚对幕撑乙炔((PPE)的合成与电致发光特性，合成的模型小分子证明，在聚对苯撑乙炔(PPV)主链引入间位幕环，可阻隔PPV的有效共轭长度，改变其发光颜色，研究了电致发光暑件ITO／m-PPE／Al的电致发光特性。     

癌症患者的负性情绪评估及护理对策

本研究采用抑郁自评问卷(SDS)与焦虑自评问卷(SAS)对100例癌症患者进行了情绪评估,并提出护理措施,现介绍如下.     

米非司酮配伍米索前列醇在中期妊娠引产中的应用

为了探讨米非司酮配伍米索前列醇在中期妊娠引产中的疗效 ,观察组 68例用米非司酮配伍米索前列醇引产 ,对照组 60例用利凡诺引产 ,观察两组从规律宫缩至胎儿娩出时间 .结果 :观察组从规律宫缩至胎儿娩出时间孕 2 0周前及孕 2 0周后分别是 ( 6 5± 0 5 2 )h和 ( 7 6± 0 4 8)h均比利凡诺组的 ( 13 2± 2 4 )h和 ( 11 1± 0 3 )h明显缩短 (P <0 0 5 ) ;而且孕 2 0周后观察组胎盘胎膜完全排出率 ( 3 8 8% )明显高于对照组 ( 2 0 % ) (P <0 0 5 ) .结论 :米非司酮配伍米索前列醇用于中孕引产具有安全有效、简便易行、无严重副作用的优点 ,是一种值得推广、使用的方法 .     

胃隐血珠加胃镜检查在上消化道体检中应用

[目的]评价健康体检中应用胃隐血珠加胃镜检查法对上消化道癌及癌前病变的意义.[方法]用秦氏胃隐血珠对上消化道系统进行初筛16782人,对阳性及强阳性者再进行胃镜检查,明确诊断.[结果]1561例胃镜检查中566例咬取活检,病理诊断癌68例,其中食管癌26例,胃癌42例.早期癌16例,占23,5%.慢性胃炎伴重度肠化生16例,伴重度异型增生5例;食管重度异型增生4例.[结论]应用秦氏胃隐血珠加胃镜检查法,对健康体检人群进行上消化道肿瘤检查,是一种简便易行的方法,可以提高早期癌及癌前病变的检出率.     

海洛因依赖者记忆力与氧化应激的关系

目的：探讨男性海洛因依赖者（MPHD）记忆力改变及其与氧化应激的关系。方法：对140例MPHD及75名健康者对照进行韦氏记忆量表（WMS）评估和氧化应激指标血清一氧化氮（NO）、丙二醛（MDA）、超氧化物歧化酶（SOD）、维生素C（VC）及总抗氧化能力（T-AOC）的检测。结果：MPHD组WMS的测验成绩显著差于对照组（P〈0．05）;MPHD组血清MDA水平高于对照组（P〈0．05）,T-AOC、VC、SOD水平低于对照组（P〈0．05或P〈0．01）;随戒断时间延长,MPHD组的记忆商数（MQ）有升高的趋势（P〉0．05）,血清MDA含量有下降的趋势（P〈0．01）,T-AOC、SOD含量有升高的趋势（P〈0．05）。MPHD组血清NO及MDA水平与WMS多个因子呈负相关（P〈0．05或P〈0．01）,T-AOC、VC及SOD水平与WMS多个因子呈正相关（P〈0．05或P〈0．01）。结论：海洛因依赖者存在明显的记忆力损害与氧化抗氧化反应失衡;其记忆力损害可能与氧化应激有关,血清NO、MDA、SOD、VC、T-AOC可能是与记忆力密切相关的氧化应激指标。     

腹腔镜辅助食管胃结合部腺癌全胃D2根治性切除功能性空肠间置与Roux-en-Y代胃重建术临床对比分析

目的 探讨腹腔镜辅助食管胃结合部腺癌(AEG)全胃D₂根治性切除功能性空肠间置(FJI)与Roux-en-Y代胃重建术的临床效果。方法 前瞻性纳入2018-09—2020-09于永城市人民医院行腹腔镜辅助全胃D₂根治性切除术的SiewertⅡ、Ⅲ型AEG患者。根据代胃重建方法分为FJI组和Roux-en-Y组。比较2组患者的基线资料、手术指标(术中出血量、代胃重建时间)、术后胃肠功能(代胃肠管内钡剂停留时间及肠管最大径值)、并发症,以及术前、术后6个月的胆囊排空率、胆囊容积、胆囊收缩素(CCK)等胆囊收缩功能指标和总蛋白(TP)、血红蛋白(Hb)、预后营养指数(PIN)等营养代谢水平指标。结果 共纳入79例患者,Roux-en-Y组40例,FJI组39例。2组患者的基线资料、术中出血量、代胃重建时间差异均无统计学意义(P>0.05)。FJI组患者术后并发症发生率低于Roux-en-Y组,代胃肠管内钡剂停留时间长于Roux-en-Y组,代胃肠管最大径值大于Roux-en-Y组,差异均有统计学意义(P<0.05)。术后6个月时,FJI...     

Observation on clinical effect of tuina plus Western medication for functional dyspepsia due to liver qi stagnation and spleen deficiency

Objective

To observe the clinical effects of tuina plus Western medication for functional dyspepsia (FD) due to liver qi stagnation and spleen deficiency.

Methods

total of 72 patients in conformity with the inclusion criteria of FD were randomly divided into an observation group and a control group based upon the random number table, 36 cases in each group. The control group was treated with mosapride citrate dispersible tablets, and the observation group was treated with the same tablets plus tuina. Before the treatment and 4 weeks after the treatment, the clinical symptoms, quality of life (QOL) and depression severity were observed by the scale, and were followed up two months later after the treatment for assessment of the clinical effects.

Results

After the treatment and at the follow-up, the symptom scores of FD and the sores of Hamilton depression rating scale (HAMD) in both groups decreased, and the scores in Chinese version of quality of life questionnaire for functional digestive disorders (Chin-FDDQL) increased, with statistically significant differences in comparison with the same group before the treatment (all P<0.05). In comparison between the two groups at the same time point after the treatment, the scores of FD symptoms, HAMD and Chin-FDDQL were improved better in the observation group than those in the control group, with statistically significant differences (all P<0.05). The total effective rates at the follow-up were 91.7% in the observation group and 75.0% in the control group, without statistical difference between the two groups (P>0.05). The rate of clinical cure and remarkable effect was 66.7% in the observation group, higher than 41.7% in the control group, it is higher in the observation group than that in the control group, with a statistically significant difference between the two groups (P<0.05).

Conclusion

Tuina plus Western medication is precise in the therapeutic effects for FD due to liver qi stagnation and spleen deficiency and can effectively relieve clinical symptoms, elevate the QOL and alleviate depression severity of the patients. Moreover, it’s better than the treatment by Western medication alone in the long-term therapeutic effects.