Experimentally investigating the effect of buccal acupuncture on analgesic time-effect characteristics and monoamine neurotransmitters

Objective

To investigate the analgesic time-effect characteristics and changes in concentrations of rabbit’s hypothalamic 5-hydroxytryptamine (5-HT) and noradrenaline (NE) caused by buccal acupuncture in the rheumatoid arthritis (RA) rabbits, and to reveal the analgesic central mechanism of buccal acupuncture, thereby providing a theoretical basis for the treatment of pain by buccal acupuncture.

Methods

Forty rabbits were randomly divided into a normal group, a model group, a body acupuncture group, and a buccal acupuncture group, with 10 rabbits in each group. No model was established in the normal group, while equal dose of normal saline was injected at the matched site and time point; rabbits in other groups were subjected to the establishment of RA models using egg protein. From the 27th day of the experiment, rabbits in each group received the designated intervention. Rabbits in the normal group and the model group were fixed for 30 min every day using the same method as those in the other groups. In the acupuncture group, Dubi (ST 35) and Zusanli (ST 36) on bilateral hind limbs were selected. Perpendicular needling (using the needles with 0.25 mm in diameter and 25 mm in length) was performed with twirling manipulation for 15 s at intervals of 5 min. The needles were retained for 30 min and acupuncture was performed once a day. In the buccal acupuncture group, the knee point in the buccal acupuncture and needles with a diameter of 0.25 mm and a length of 15 mm were selected. Oblique needling was performed with twirling manipulation for 15 s at intervals of 5 min. The needles were retained for 30 min and acupuncture was performed once a day. The thermal pain thresholds at the 0, 5, 15, 30, 60, 120 and 240 min after the 1st and 10th acupuncture therapy were measured with a PL-200 thermal-inducing pain meter. After the 10th acupuncture therapy, rabbit’s hypothalamus was removed, and the 5-HT and NE concentrations in the hypothalamus at the peak point of the acupuncture pain threshold curve were determined by high performance liquid chromatography (HPLC).

Results

The analgesic effect was obvious at 5 min after buccal acupuncture started, peaked at 30 min, and decreased to the lowest value at 240 min. Rabbits in the body acupuncture group began to show significant analgesic effect at 15 min, which was peaked at 30 min, and began to decline at 60 min. The pain threshold at 240 min was still higher than that at 0 min. Compared with the model group, the concentrations of hypothalamic 5-HT in the buccal acupuncture group and the body acupuncture group was significantly increased, and the between-group differences were statistically significant (both P<0.05). The NE/5-HT ratios in hypothalamus in the buccal acupuncture group and the body acupuncture group were significantly lower than the ratio in the model group, and the differences were statistically significant (both P<0.05); difference in the decrease was statistically significant between the buccal acupuncture group and the body acupuncture group (P<0.05).

Conclusion

The analgesic effect of buccal acupuncture shows an obvious time-dependent curve. It is characterized by rapid onset of pain relief, rapid increase and decline in pain threshold. 5-HT and NE levels in rabbit’s hypothalamus can be affected by buccal acupuncture, with increased 5-HT concentration and reduced NE/5-HT ratio.

     

郑氏“凉泻”针法治疗复发型单纯疱疹案

<正>患者,男,77岁。就诊日期：2021年1月23日。主诉：反复口周疱疹1个月,加重3 d。现病史：1个月前劳累后出现口唇红肿,灼热不适,随后口周出现红斑、簇集性疱疹,自觉皮肤烧灼刺痛,夜间加重,曾就诊于某医院,诊断为“单纯疱疹”,予以抗病毒治疗（具体药物不详）后有所缓解,但易反复,症状时轻时重。3 d前无明显诱因上述症状再次出现,     

Buccal acupuncture plus exercise therapy for scapulohumeral periarthritis

Objective

To observe the clinical efficacy of buccal acupuncture plus exercise therapy in treating scapulohumeral periarthritis (SP).

Methods

Sixty-three SP patients were intervened by buccal acupuncture plus exercise therapy. The treatment was given once every day, 5 sessions as a course, with a 2-3 d interval between two courses. The therapeutic efficacy was observed after 3 courses of treatment.

Results

Thirty-five patients were recovered, 23 cases were improved, while 5 cases showed ineffective, and the total effective rate was 92.1%.

Conclusion

Buccal acupuncture plus exercise therapy can produce a significant efficacy in treating SP, and thus is worth promotion in clinic.

     

重型胰腺炎术后胰床低温冲洗的护理

对30例重型胰腺炎病人于术后用6～8℃0.9%氯化钠注射液经胰床入水管注入胰床,以清除胰酶、毒性物质和坏死组织,利于胰腺组织的恢复;冲洗液从胰床出水管流出,通过观察引流液的量和颜色,以了解胰腺组织病情变化.结果 27‘例治愈,3例死亡.提出良好的护理是保证术后胰床低温冲洗病人治愈的有效措施.     

针刺配合中药面部穴位按摩治疗黄褐斑58例

针刺配合中药面部穴位按摩治疗黄褐斑５８例方晓丽①许雨均②马少芳①关键词黑变病黄褐斑穴位按摩针刺疗法中图分类号Ｒ２４６．８黄褐斑是一种常见的多因素致病的皮肤色素沉着性疾病。近两年来笔者采用针刺配合中药面部穴位按摩法，治疗黄褐斑病人５８例，并与２５例口服...     

药源性疾病的防治

大多数人关注的是怎样用药治病 ,但药物也可能成为致病因素。药物具两重性 ,随着人类对药物滥用所致危害的深入认识 ,药源性疾病 (drug induceddiseases ,DID)日益受到重视。从对药物不良反应 (ADR )的认识到DID及药物流行病学(pharmacoepidemiology)作为边缘学科的正式提出 ,说明人类对药物应用高度重视。据乌普拉监测中心 (UMC)统计 ,2 0 0 2年因ADR致死人数达 10 60 0 0例 ,DID是第 4位导致死亡的原因[1 ] 。DID已对人类的健康构成威胁。DID是由于用药而引起的药物对人体的不良反应 ,是药物本身、药物使用者、药物接受者等方面…     

郑魁山教授"温通"针法临证运用规律总结

“温通针法”是郑魁山教授在数十年的临床实践中,独创的治疗各种疑难杂症的特色针刺手法,该手法补泻兼施,具有温经通络、化痰浊、祛风散寒、行气活血、扶正驱邪的作用,临床用于治疗冠心病、头面五官疾病、脑病、风寒湿痹等难治性病症,常获良效。     

学思鼎新承前启后精湛针艺造福苍生——郑魁山教授成才之路经验总结

从坚实的根基、高尚的医德、锐意创新的精神、医教研并重4个方面总结郑魁山教授成才之经验。     

温针灸治疗肩关节周围炎随机对照临床研究文献Meta分析

目的：系统评价温针灸治疗肩关节周围炎的疗效。方法：对1998年1月-2012年12月中国期刊全文数据库（CNKI）、万方数据库中相关文献进行电子检索,纳入温针灸治疗肩周炎与其他疗法比较的随机对照试验（RCT）和临床对照试验（CCT）根据Jadad评分标准评价纳入研究项目的质量。使用RevMan5.1版进行Meta分析统计学处理。结果：9篇文献符合纳入标准,共计1076例患者。Meta分析结果显示温针灸能显著治疗肩关节周围炎,温针灸治疗组总优势比OR=7.59,95%置信区间（CI）为（4.35-13.27）。两者差异有统计学意义（P〈0.00001）;＂漏斗图＂图形显示存在发表偏倚。结论：资料表明温针灸治疗肩关节周围炎临床疗效显著。尤其在改善症状及整体疗效方面,但还需要高量的随机对照试验进一步验证支持。     

颊针结合运动疗法治疗急性腰扭伤56例

正颊针是根据生物全息论,针刺面颊部相应穴位治疗疾病的方法,经多年、大量临床实践验证,疗效稳定可靠,对疼痛性病症效果尤为明显[1]。笔者采用颊针结合运动疗法治疗急性腰扭伤56例,现报道如下。1临床资料56例患者均来自2012至2013年甘肃中医学院附属医院针灸科门诊,其中男32例,女24例;年龄最小17岁,最大56岁,平均38岁;病程最短40min,最长4天。经X线、CT等检查后,排除骨