首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   237篇
  免费   27篇
  国内免费   2篇
基础医学   3篇
口腔科学   1篇
临床医学   4篇
内科学   1篇
皮肤病学   199篇
神经病学   1篇
特种医学   2篇
外科学   4篇
综合类   2篇
预防医学   16篇
药学   28篇
中国医学   1篇
肿瘤学   4篇
  2023年   9篇
  2021年   12篇
  2020年   11篇
  2019年   20篇
  2018年   10篇
  2017年   9篇
  2016年   10篇
  2015年   6篇
  2014年   17篇
  2013年   13篇
  2012年   10篇
  2011年   11篇
  2010年   12篇
  2009年   13篇
  2008年   13篇
  2007年   8篇
  2006年   5篇
  2005年   8篇
  2004年   9篇
  2003年   7篇
  2002年   12篇
  2001年   5篇
  2000年   5篇
  1999年   3篇
  1998年   2篇
  1996年   3篇
  1995年   5篇
  1994年   3篇
  1993年   1篇
  1992年   1篇
  1990年   3篇
  1989年   2篇
  1987年   4篇
  1986年   1篇
  1984年   1篇
  1983年   1篇
  1982年   1篇
排序方式: 共有266条查询结果,搜索用时 14 毫秒
1.
Frontal fibrosing alopecia (FFA) is a primary patterned cicatricial alopecia with a complicated pathogenesis yet to be fully understood. FFA appears to be increasing in incidence worldwide, especially in the last decade. In order to consider current treatment options, we reviewed current evidence for its pathogenesis comprising immune-mediated, genetic, hormonal and environmental factors. Th1-mediated inflammation with collapse of hair follicle immune privilege and bulge epithelial stem cell destruction, peroxisome proliferator-activated receptor gamma (PPAR-γ) depletion and epithelial–mesenchymal transition are key events leading to permanent hair follicle destruction in FFA. Although the vast majority of cases are sporadic, familial reports of FFA implicate genetic or epigenetic mechanisms in its pathogenesis. The frequent onset of FFA in post-menopausal women, similar patterning and co-existence with female pattern hair loss, together with a reportedly good response to 5α-reductase inhibitors suggest a role for sex steroid hormones. The reported increasing incidence invites speculation for, yet unproven, environmental triggers such as sun exposure and topical allergens. More robust research into this unique entity is required to help understand the complexity of the pathogenesis of FFA in order to find satisfactory therapeutic targets for this often distressing condition.  相似文献   
2.
3.
4.
5.
Oxybenzone or benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is a filter used in a variety of personal care products for protection of human skin and hair from damage by ultraviolet radiation. BP-3 is suspected to exhibit endocrine disruptive properties. Indeed, it was found to be able to interact with the endocrine system causing alteration of its homeostasis, with consequent adverse health effects. Moreover, it is ubiquitously present in the environment, mostly in aquatic ecosystems, with consequent risks to the health of aquatic organisms and humans. In the present study, we analyzed the cytogenetic effects of BP-3 on human lymphocytes using in vitro chromosomal aberrations and micronuclei assays. Blood samples were obtained from five healthy Italian subjects. Lymphocyte cultures were exposed to five concentrations of BP-3 (0.20, 0.10, 0.05, 0.025, and 0.0125?μg/mL) for 24 and 48?h (for chromosomal aberrations and micronuclei tests, respectively). The concentration of 0.10?µg/mL represents the acceptable/tolerable daily intake reference dose established by European Union, whereas 0.20, 0.05, 0.025, and 0.0125?µg/mL represent multiple and sub-multiple of this concentration value. Our results reported cytogenetic effects of BP-3 on cultured human lymphocytes in terms of increased micronuclei and chromosomal aberrations’ frequencies at all tested concentrations, including concentrations lower than those established by European Union. Vice versa, after 48-h exposure, a significant reduction of the cytokinesis-block proliferation index value in cultures treated with BP-3 was not observed, indicating that BP-3 does not seem to produce effects on the proliferation/mitotic index when its concentration is equal to or less than 0.20?μg/mL.  相似文献   
6.
7.
8.
9.
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号