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1.
目的 建立同时测定多效防护霜中盐酸苯海拉明、甲氧基肉桂酸辛酯和水杨酸辛酯的含量的方法。方法 采用高效液相色谱法。色谱柱为Agilent Extend-C18(4.6 mm×150 mm,5 μm),流动相为甲醇-乙酸铵缓冲溶液(20 mmol/L,pH=7.5),梯度洗脱,甲醇比例随时间变化为:0~10 min、甲醇→60%;10~12 min、甲醇60%→92%;12~20 min、甲醇→92%,采集时间20 min,平衡时间10 min,流速1 ml/min,紫外检测波长218 nm,柱温25℃,进样量15 μl。结果 3种成分在30 min内基线分离,方法学验证表明,线性关系良好(r>0.9995),日内日间精密度均小于3.0%,回收率在90%~108%之间,稳定性和重复性RSD均<3.0%,符合方法学要求。按照新建立的方法测定了3个批次样品中3种成分的含量,结果符合要求。结论 本方法简便可靠,可为多效防护霜的质量控制提供依据,也为其质量标准研究奠定了基础。 相似文献
2.
Carmelo Puglia Francesco Bonina Francesco Castelli Dorotea Micieli Maria Grazia Sarpietro 《The Journal of pharmacy and pharmacology》2009,61(8):1013-1019
Objectives Diethyltoluamide and ethylhexyl p‐methoxycinnamate (OMC) are two active ingredients in insect repellent and sunscreen products, respectively. The concurrent application of these two substances often increases their systemic absorption, compromising the safety and efficiency of the cosmetic product. In this study, diethyltoluamide and OMC were incorporated into solid lipid nanoparticles, a colloidal drug delivery system, to reduce percutaneous absorption and avoid toxic effects and also maintain the efficacy of the two active compounds on the skin surface for a long duration. Methods Solid lipid nanoparticles were prepared based on an ultrasonication technique and characterized by differential scanning calorimetry (DSC) analyses. In‐vitro studies determined the percutaneous absorption of diethyltoluamide and OMC. Key findings DSC data carried out on unloaded and diethyltoluamide‐ and/or OMC‐loaded solid lipid nanoparticles highlighted that diethyltoluamide and OMC modified the temperature and the enthalpy change associated to the calorimetric peak of solid lipid nanoparticles. The concurrent presence of the two compounds in the solid lipid nanoparticles caused a synergic effect, indicating that the lipid matrix of nanoparticles guaranteed a high encapsulation of both diethyltoluamide and OMC. Results from the in‐vitro study demonstrated that the particles were able to reduce the skin permeation of the two cosmetic ingredients in comparison with an oil‐in‐water emulsion. Conclusions This study has provided supplementary evidence as to the potential of lipid nanoparticles as carriers for topical administration of cosmetic active compounds. 相似文献
3.
Wim Jiskoot Tom Teerlink E. Coen Beuvery Daan J. A. Crommelin 《Pharmacy World & Science》1986,8(5):259-265
Liposomes were prepared from mixed micelles by a dilution method. Mixed micellar solutions, containing constant octyl glucoside and egg phosphatidylcholine concentrations and varying amounts of cholesterol and/or a charged compound, were diluted at defined rates. After dilution, the resulting liposome dispersions were sequentially concentrated, washed or dialysed, and filtered. The effect of lipid composition and experimental conditions on physicochemical characteristics was studied. Fairly homogeneous liposome dispersions with mean diameters ranging from 100 to over 200 nm could be obtained. The particle size was dependent on cholesterol content and surface charge, and could be reproducibly controlled by adjustment of the dilution rate. Liposomes with a mean diameter below 100 nm could also be obtained, but were heterodisperse and unstable. The incorporation of charged compounds was monitored by microelectrophoresis.31P-NMR measurements indicated that the liposomes were unilamellar. Dialysis appeared to be more convenient than washing to remove octyl glucoside. 相似文献
4.
5.
We report a case of photoallergic contact dermatitis to two sunscreen agents, methoxycinnamate and oxybenzone, occurring in a 6-year-old Asian boy. 相似文献
6.
Unlike acetylcholine, caffeine was much more effective in releasing catecholamine in the absence of extracellular Ca2+ than in its presence in perfused cat adrenal glands. The intracellular Ca2+ antagonist, TMB-8 (10−4 M), inhibited reversibly the catecholamine secretion evoked by caffeine (40 mM) and that induced by acetylcholine (10−4 M) in the presence of hexamethonium (10−3 M) during perfusion with Ca2+-free Locke solution containing EGTA (10−5 M). These results support our view that muscarinic receptor activation causes catecholamine secretion by mobilizing Ca2+ from an intracellular pool just as caffeine does. 相似文献
7.
K.A. Walters K.R. Brain D. Howes V.J. James A.L. Kraus N.M. Teetsel M. Toulon A.C. Watkinson S.D. Gettings 《Food and chemical toxicology》1997,35(12):1219-1225
The human skin penetration of [14C]octyl salicylate from two representative sunscreen vehicles was determined in vitro. 3H-sucrose was incorporated into all formulations and provided a marker for membrane integrity. When applied as a finite dose in an oil-in-water emulsion vehicle containing 5% (w/w) octyl salicylate, the average total absorption of 14C over 48 hr was 0.65 ± 0.16% of the applied dose (representing a total amount permeated of 1.58 ± 0.36 μg/cm2). When applied as an infinite dose in the oil-in-water emulsion vehicle the average total absorption of 14C over 48 hr was 0.47 ± 0.22% of the applied dose (representing a total amount permeated of 27.54 ± 13.91 μg/cm2). When applied as a finite dose in a representative hydroalcoholic formulation containing 5% (w/w) octyl salicylate, the average total absorption of 14C over 48 hr was 0.59 ± 0.09% of the applied dose (representing a total amount permeated of 1.58 ± 0.25 μg/cm2). When applied as an infinite dose in the hydroalcoholic formulation the average total absorption of 14C over 48 hr was 0.23 ± 0.05% of the applied dose (representing a total amount permeated of 11.28 ± 2.55 μg/cm2). The penetration of [14C]salicylic acid [applied at a concentration of 2.7% (w/w), in the oil-in-water emulsion] was also determined. When applied as a finite dose the average total absorption of 14C over 48 hr was 1.14 ± 0.23% of the applied dose (representing a total amount permeated of 1.65 ± 0.39 μg/cm2). These results suggest that the in vitro human skin permeation of octyl salicylate is relatively low. The amounts of octyl salicylate and salicylic acid permeated when applied in similar vehicles were remarkably similar over 48 hr (1.58 μg/cm2 and 1.65 μg/cm2, respectively). This suggests the possibility that the 14C label appearing in the receptor fluid may, in both cases, represent salicylic acid. If this is the case, then it is possible that the amount of octyl salicylate permeating through the skin is much less than that suggested by the data obtained here. This supposition is, however, entirely speculative and has yet to be confirmed experimentally. 相似文献
8.
8 alkyl gallates, including the widely used antioxidants propyl, octyl, and dodecyl (= lauryl) gallate, have been subjected to experimental sensitization in guinea pigs. Using a modern sensitization procedure, the results showed that all gallates are moderate to strong contact sensitizers: dodecyl (= lauryl) gallate was found to be the strongest. A characteristic correlation between side chain length and mean response was observed, giving a maximum of sensitization at a length of 12 carbon atoms (dodecyl gallate). A literature review revealed that the frequency of reports of allergic contact dermatitis from antioxidants of the gallate type has increased in the last 4 years. In most cases, the moderate sensitizer propyl gallate was the source of sensitization. 相似文献
9.
钙拮抗剂TMB-8抑制BHQ,NE和KCl引起的培养乳牛基底动脉单个平滑肌细胞内游离钙的升高 总被引:1,自引:0,他引:1
用ARCMMIC阳离子测定系统,测量单个细胞内游离钙浓度([Ca2+]i),研究8(N,N二乙胺)n辛基3,4,5三甲氧基苯甲酸酯(TMB8)对培养乳牛基底动脉平滑肌[Ca2+]i的作用。在细胞外钙浓度为13mmol·L-1时,TMB8(30μmol·L-1)可明显抑制BHQ,NE及KCl引起[Ca2+]i的升高。在细胞外钙为零+EGTA01mmol·L-1时,TMB8(10,30及100μmol·L-1)可浓度依赖性地降低静息[Ca2+]i,TMB8(30μmol·L-1)可几乎完全阻断BHQ及NE引起[Ca2+]i的增加。研究表明TMB8降低培养乳牛基底动脉平滑肌[Ca2+]i的机制,主要是抑制肌浆网Ca2+的释放,或增加肌浆网对Ca2+的摄入,并由此间接地抑制细胞外钙的内流。 相似文献