全文获取类型
收费全文 | 8358篇 |
免费 | 882篇 |
国内免费 | 205篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 183篇 |
妇产科学 | 99篇 |
基础医学 | 985篇 |
口腔科学 | 228篇 |
临床医学 | 940篇 |
内科学 | 844篇 |
皮肤病学 | 87篇 |
神经病学 | 457篇 |
特种医学 | 137篇 |
外国民族医学 | 1篇 |
外科学 | 474篇 |
综合类 | 998篇 |
预防医学 | 1566篇 |
眼科学 | 120篇 |
药学 | 1286篇 |
25篇 | |
中国医学 | 581篇 |
肿瘤学 | 401篇 |
出版年
2023年 | 161篇 |
2022年 | 196篇 |
2021年 | 363篇 |
2020年 | 404篇 |
2019年 | 345篇 |
2018年 | 317篇 |
2017年 | 387篇 |
2016年 | 358篇 |
2015年 | 352篇 |
2014年 | 582篇 |
2013年 | 756篇 |
2012年 | 510篇 |
2011年 | 535篇 |
2010年 | 419篇 |
2009年 | 414篇 |
2008年 | 361篇 |
2007年 | 400篇 |
2006年 | 321篇 |
2005年 | 282篇 |
2004年 | 243篇 |
2003年 | 168篇 |
2002年 | 161篇 |
2001年 | 142篇 |
2000年 | 122篇 |
1999年 | 78篇 |
1998年 | 80篇 |
1997年 | 78篇 |
1996年 | 69篇 |
1995年 | 71篇 |
1994年 | 63篇 |
1993年 | 60篇 |
1992年 | 67篇 |
1991年 | 48篇 |
1990年 | 40篇 |
1989年 | 46篇 |
1988年 | 35篇 |
1987年 | 28篇 |
1986年 | 37篇 |
1985年 | 44篇 |
1984年 | 48篇 |
1983年 | 30篇 |
1982年 | 32篇 |
1981年 | 35篇 |
1980年 | 21篇 |
1979年 | 21篇 |
1978年 | 24篇 |
1977年 | 16篇 |
1976年 | 23篇 |
1974年 | 9篇 |
1973年 | 13篇 |
排序方式: 共有9445条查询结果,搜索用时 31 毫秒
1.
《Clinical oncology (Royal College of Radiologists (Great Britain))》2022,34(10):e421-e429
AimsTo determine the relationship between local relapse following radical radiotherapy for muscle-invasive bladder cancer (MIBC) and radiation dose.Materials and methodsPatients with T2-4N0-3M0 MIBC were recruited to a phase II study assessing the feasibility of intensity-modulated radiotherapy to the bladder and pelvic lymph nodes. Patients were planned to receive 64 Gy/32 fractions to the bladder tumour, 60 Gy/32 fractions to the involved pelvic nodes and 52 Gy/32 fractions to the uninvolved bladder and pelvic nodes. Pre-treatment set-up was informed by cone-beam CT. For patients who experienced local relapse, cystoscopy and imaging (CT/MRI) was used to reconstruct the relapse gross tumour volume (GTVrelapse) on the original planning CT . GTVrelapse D98% and D95% was determined by co-registering the relapse image to the planning CT utilising deformable image registration (DIR) and rigid image registration (RIR). Failure was classified into five types based on spatial and dosimetric criteria as follows: A (central high-dose failure), B (peripheral high-dose failure), C (central elective dose failure), D (peripheral elective dose failure) and E (extraneous dose failure).ResultsBetween June 2009 and November 2012, 38 patients were recruited. Following treatment, 18/38 (47%) patients experienced local relapse within the bladder. The median time to local relapse was 9.0 months (95% confidence interval 6.3–11.7). Seventeen of 18 patients were evaluable based on the availability of cross-sectional relapse imaging. A significant difference between DIR and RIR methods was seen. With the DIR approach, the median GTVrelapse D98% and D95% was 97% and 98% of prescribed dose, respectively. Eleven of 17 (65%) patients experienced type A failure and 6/17 (35%) patients type B failure. No patients had type C, D or E failure. MIBC failure occurred in 10/17 (59%) relapsed patients; of those, 7/11 (64%) had type A failure and 3/6 (50%) had type B failure. Non-MIBC failure occurred in 7/17 (41%) patients; 4/11 (36%) with type A failure and 3/6 (50%) with type B failure.ConclusionRelapse following radiotherapy occurred within close proximity to the original bladder tumour volume and within the planned high-dose region, suggesting possible biological causes for failure. We advise caution when considering margin reduction for future reduced high-dose radiation volume or partial bladder radiotherapy protocols. 相似文献
2.
ObjectivesOsteoclasts can sense the surface topography of materials. However, it is difficult to identify the structural factors that affect osteoclast formation and its function. Furthermore, we hypothesized that the type of osteoclast precursor cells also affects osteoclastogenesis in the materials. In this study, we investigated the effects of defined micro/nanoscale patterns on osteoclastogenesis from bone marrow cells (BMCs).MethodsVarious cyclo-olefin polymer (COP) patterns were prepared using nanoimprinting. The effects of shape, size, and height of the patterns, and the wettability of the patterned surfaces on osteoclastogenesis from BMCs were evaluated in vitro.ResultsOsteoclast formation was promoted on pillars (diameter, 1 μm or 500 nm; height, 500 nm). Notably, osteoclastogenesis from BMCs was better promoted on hydrophobic pillars than on hydrophilic pillars. In contrast, decreased osteoclast formation was observed on the nanopillars (diameter, 100 nm; height, 200 nm).ConclusionsWe demonstrated the promotion of osteoclast formation from BMCs on hydrophobic pillars with diameters of 1 μm and 500 nm. Some cellular behaviors in the patterns were dependent on the type of osteoclast precursor cells. The designed patterns are useful for designing the surface of dental implants or bone replacement materials with a controllable balance between osteoblast and osteoclast activities. 相似文献
3.
2019年1月1日公立医院正式开始实施新政府会计制度,通过研究公立医院在新制度下会计核算的衔接问题以及适应问题,找出公立医院会计核算将面临的难点,如固定资产及其累计折旧核算方式、应付职工薪酬、科教项目核算等,并给出相应的解决对策,如利用信息化手段对应付职工薪酬进行资金分配、利用成本配比处理医院科教项目核算难点等,帮助公立医院能够在改革中进步,提升公立医院会计核算管理水平。 相似文献
4.
摘要:目的对1 个扩张型心肌病的家系进行遗传学分析,探讨其致病性基因变异位点,为遗传咨询提供数据支持。方法收集该家系现存成员的临床资料和外周血,采用外周血DNA提取试剂盒提取白细胞基因组DNA,采用全外显子组二代测序技术筛选出与扩张型心肌病相关的可疑致病性变异,用Sanger 测序对变异位点进行验证,结合家系共分离分析及多种生物信息学方法(如UniProt、PolyPhen-2和Mutation taster 、ANTHEPROT PyM0L等)综合验证和预测该变异的有害性,并根据ACMG指南对该变异位点进一步解读。结果该扩张型心肌病家系符合常染色体显性遗传模式,患病成员均携带结蛋白基因(desmin,DES) ,是未曾报道过的一种杂合错义新突变DES c. 140G>T( p.Ser471le)。生物信息学预测结果显示,该突变可改变蛋白质的二级结构,增加其疏水性并使其抗原性下降,还可使该位点原有的氢键和潜在的磷酸化位点丢失。根据ACMG指南可将该突变解读为可能致病的变异。结论新发现的 DES基因c.140G>T(p.Ser47le)变异可能是该常染色体显性遗传家系的致病原因,该家系患者出现临床表型的时间相对较早且预后不良,突变的检测有助于患者早期诊断与个性化的临床管理及治疗。 相似文献
5.
目的 了解新入职护士医学叙事能力现状,并分析其影响因素。方法 采用便利抽样法,于2021年12月—2022年1月选取南昌市某三级甲等医院的422名新入职护士作为研究对象。采用一般资料调查表、医学叙事能力量表、家庭关怀度量表、护士职场适应度量表对其进行调查。采用多重线性回归分析新护士医学叙事能力的影响因素。结果 本组新入职护士医学叙事能力总分为(139.06±20.79)分。多重线性回归分析显示,家庭关怀度、护士职场适应度和叙事护理开展观点进入回归方程(P<0.01),共解释新入职护士医学叙事能力总变异的43.5%。结论 本组新入职护士医学叙事能力处于中等偏上水平,家庭关怀度、护士职场适应度和叙事护理开展观点是其叙事能力的主要影响因素。护理管理者应实施针对性培训,以提高其叙事能力水平,助力专业成长。 相似文献
6.
目的 分析新型半导体激光联合康复新液治疗Ⅲ期/C级牙周炎患者的临床效果。方法 选取2021年1-10月在武警特色医学中心口腔颌面科牙周组就诊且诊断为Ⅲ期/C级牙周炎患者60例,常规进行牙周非手术治疗,即行龈上洁治术、龈下刮治术及根面平整。术后采用自体比对,根据牙列的左右相对应分成对照组和试验组。两组均进行康复新液袋内冲洗含漱;试验组在此基础上加入新型半导体激光治疗。比较两组治疗的临床有效率,治疗前与治疗后1、3、6个月的牙周临床指数(牙龈指数、出血指数、探诊深度、附着水平)变化,治疗前及治疗6个月后牙槽骨高度变化。结果 治疗后试验组临床总有效率96.7%,高于对照组的90.0%(P<0.05);两组牙周临床指数均较前有所下降,试验组低于对照组,差异有统计学意义(P<0.05);治疗后6个月,试验组的牙槽骨高度明显增高,对照组前后对比,差异无统计学意义(P>0.05),两组间比较差异有统计学意义(P<0.05)。结论 新型半导体激光联合康复新液辅助治疗Ⅲ期/C级牙周炎患者的临床效果显著,值得推广。 相似文献
7.
8.
目的研究新型射频治疗对女性性功能障碍的治疗效果。方法回顾性分析在湖南省妇幼保健院2020年7月至2021年2月期间门诊就诊的性功能障碍女性患者35例行新型射频治疗前后的临床资料。患者平均年龄(36.0±6.7)岁,均为经产妇。性生活满意度问卷(SSQ)评价中非常不满意13例,差19例,中等3例,对患者予以新型射频治疗(每次25分钟,每14天治疗一次,5次为一个疗程),1个疗程后对患者进行随访,采用女性性功能指数评估(FSFI),阴道松弛度问卷(VLQ),外阴阴道松弛度问卷(VVLQ)及盆底肌肌力等级评价治疗疗效。结果患者治疗后FSFI评分由(12.4±2.6)分上升至(23.4±2.9)分,治疗前后差异具有统计学意义(P<0.05),74.3%患者盆底肌恢复至III级以上。结论新型射频在治疗女性患者性功能障碍方面,具有显著的临床疗效,具有推广价值。 相似文献
9.
10.
Dong Kyu Kim Joon Ho Kwon Heung Kyu Ko Junhyung Lee Kichang Han Gyoung Min Kim Man-Deuk Kim Jong Yun Won Hyun-Chel Joo Young-Guk Ko Do Yun Lee 《Journal of vascular and interventional radiology : JVIR》2021,32(1):39-48
PurposeTo evaluate the feasibility, safety, and effectiveness of N-butyl cyanoacrylate (NBCA) embolization for the treatment of aortic dissection.Materials and MethodsIn this single-center retrospective study conducted from February 2003 to June 2019, NBCA embolization of an aortic false lumen was attempted in 12 patients (median age, 59 y; range, 41–68 y) and thoracic endovascular aortic repair (TEVAR) was performed in 53 patients (median age, 59 y; range, 37–70 y) for aortic dissection with one or more indications of persisting pain, malperfusion, rupture or impending rupture, maximal aortic diameter ≥ 55 mm, and/or rapid aortic enlargement. The main exclusion criterion for embolization was the presence of fast blood flow in the aortic false lumen on aortography. The efficacy of NBCA embolization and TEVAR was compared by evaluating technical and clinical outcomes, repeat intervention–free survival (RFS), and overall survival (OS).ResultsTechnical success was achieved in 11 of the 12 patients treated with NBCA embolization (91.7%), and clinical success was achieved in 9 of these 11 (81.8%). No significant difference was found between embolization and TEVAR in clinical success rates (embolization, 81.8%; TEVAR, 84.9%; P = .409) or procedure-related complications (embolization, 1 patient [8.3%]; TEVAR, 4 patients [7.5%]; P = .701). In addition, embolization showed comparable 5-y RFS (embolization, 82.5% ± 9.3; TEVAR, 85.5% ± 4.8; P = .641) and 5-y OS (embolization, 100%; TEVAR, 95.4% ± 3.2; P = .744) rates to TEVAR.ConclusionsNBCA embolization of the false lumen in aortic dissection seems to be a safe and effective treatment modality for the closure of false lumen in selected patients. 相似文献