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1.
Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar rats.Methods Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups(A-E).Rats in group A(negative control) were orally administered,once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B,C,D,and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone(group B,reference drug),250,500 and 1 000 mg/kg body weight of the extract respectively(groups C-E).Results Phytochemical screening of the extract showed positive results for saponins(1.22%),flavonoids(1.06%),cardiac glycosides(0.20%),cardenolides and dienolides(0.18%),phenolics(0.44%) and alkaloids(0.52%).Respiratory distress,salivation,diarrhoea,changes in the appearance of hair as well as maternal mortality were not observed at any time during the exposure period except in the mifepristone-treated animals where there was episode of diarrhoea and tiredness.The extract significantly reduced(P〈0.05) the number of life foetus,weight and survival ratio of the foetus,numbers of implantations and Corpora lutea,implantation index,progesterone,prolactin,estradiol,follicle stimulating and luteinizing hormones whereas the number of dead foetus,number and percentage of rats that aborted,percentage vaginal opening,resorption index,pre-and post-implantation losses increased significantly.In addition,mifepristone-treated animals produced resorption index that compared well with the distilled water control.There was also no dead or life foetus and serum progesterone concentration was increased in the animals treated with mifepristone.All cases of abortion were accompanied with vaginal bleeding.Although,the final weight of the rats increased significantly,the feed and water intake were not significantly altered in all the treatment groups.The weight of the uterus,uterine-body weight ratio,length of the right uterus horn and uterine cholesterol decreased significantly in all the treatment groups.The uterine alkaline phosphatase activity and glucose concentration increased in only the extract-treated animals whereas mifepristone decreased the uterine alkaline phosphatase activity and glucose content of the animals.Conclusion This study has provided evidence to the age-long claim of S.alata leaves in "washing the uterus".The abortifacient properties were most pronounced at 500 and 1 000 mg/kg body weight of the extract and were similar to the animals treated with 2.85 mg/kg body weight of mifepristone.Hormonal influence,changes in implantation site,estrogenicity and uterogenicity are suggested as possible mechanism of abortifacient activity of aqueous extract of S.alata leaves.Overall,the extract may be used as an abortifacient especially at 500 and 1 000 mg/kg body weight and therefore not safe for consumption as oral remedy during pregnancy.  相似文献   
2.
小花棘豆中黄酮醇和黄酮醇甙的分离鉴定   总被引:9,自引:1,他引:8  
从小花棘豆的地上部分分离到九个黄酮类化合物,鉴定了其中的五个为山奈酚,檞皮素,山奈酚-7-鼠李糖甙,山奈酚-3-葡萄糖甙和山奈酚-3-双葡萄搪甙。均为首次从该植物中分离得到。  相似文献   
3.
The anti-inflammatory activity of Cleome arabica leaf extract was studied in vivo and in vitro. Firstly, the extract was examined for its anti-inflammatory activity using carrageenan-induced rat paw edema as a model of acute inflammation. A subplantar injection of 0.1 ml of carrageenan 1% induced a progressive swelling of the rat paw in all time points, that reached a maximal volume in placebo group within 5 h. Results showed that pre-treatment of rats by Cleome arabica leaf extract, 1 h prior the injection of the phlogogenic agent, prevented the increase of the edema in dose-dependent manner with an ED 50 of 231 mg/kg, body weight. The extract doses 100, 200 and 300 mg/kg, reduced edema to 65.54 ± 5.2%, 57.86 ± 8%, and 41.54 ± 3.6%, respectively, 5 h after the carrageenan injection. Secondly, we have examined the effect of Cleome arabica leaf extract on human neutrophil migration induced by fMLP (10 -7 M), using 48-well chemotaxis chamber. Results showed that the extract inhibited neutrophil chemotaxis significantly (p < 0.01) and in a dose-dependent manner. Neutrophil migration was reduced to 16.71 ± 4.6% in presence of 50µg/ml of Cleome arabica leaf extract. It appears that the antiinflammatory activity of Cleome arabica leaf extract, observed in vivo as well as in vitro, could be due to its high flavonoid content (19%). These results may contribute to explain the use of this plant in folk medicine.  相似文献   
4.
A new di-O-prenylated isoflavone, 5,7-di-O-prenylbiochanin A (1), together with three known compounds, 7-O-methylglabranin (2), tephrowatsin C (3) and flemichapparin B (4), were isolated from the stems of Tephrosia tinctoria. The structures of these compounds were elucidated by extensive 2D NMR spectral studies.  相似文献   
5.
对河北苍岩山苦参地上部分生物碱的分布状况进行了薄层层析比较,并用薄层光密度法进行了总生物碱和含量最高的槐定碱的含量测定,总生物碱含量在0.75~0.96%范围,其中槐定碱占总碱的50~70%。  相似文献   
6.
An investigation of CH2Cl2 and EtOH extracts of Trifolium resupinatum L. var. microcephalum Zoh. has led to the isolation of two new compounds characterized as 4,15-dimethyl-2-(1,2-dihydroxyethyl)-hexadecene (1) and 1-undecene-1-O-β-2′,3′,4′,6′-tetraacetyl glucopyranoside (2a). Their structures were established by 1D and 2D NMR techniques, and mass spectroscopy.  相似文献   
7.
红绒毛羊蹄甲的化学成分研究   总被引:16,自引:7,他引:16  
目的:研究红绒毛羊蹄甲Bauhinia aurea的化学成分。方法:应用各种色谱技术进行分离纯化,用MS和NMR分析鉴定化合物结构。结果:从90%乙醇提取物中分离得到12个化合物,分别为:3,4-二羟基苯甲酸(1),4-羟基苯甲酸(2),3-羟基-4-甲氧基苯甲酸(3),4-羟基-3-甲氧基苯甲酸(4),没食子酸(5),没食子酸甲酯(6),没食子酸乙酯(7),羽扇豆-3-醇(8),羽扇豆-3-酮(9),豆甾-4-烯-3-酮(10),β-谷甾醇(11)和胡萝卜苷(12)。结论:除化合物5,8,11和12外,其余化合物均属首次从该属植物中发现。  相似文献   
8.
合欢皮中的三萜皂苷   总被引:2,自引:0,他引:2  
合欢皮作为传统中药,为豆科植物合欢的干燥茎皮。在1995年版中国药典中记载合欢皮具有解郁安神、活血化瘀的作用。在我们对传统中药品质进行研究的过程中,通过对合欢皮95%乙醇提取物的正丁醇可溶部位进行一系列溶剂处理和层析分离,分离获得28个五环三萜皂苷。基于化学和波谱证据,我们鉴定了它们的结构,包括6对非对映异构体、5对位置异构体,其中26个皂苷为新化合物。所有分离皂苷均为三糖链皂苷,含有金合欢酸皂苷元,7~9个单糖和1~2个单萜酸酯衍生物,分子量大于2000。根据它们的一维、二维核磁共振数据归属了这些皂苷的所有碳信号和大多数质子信号,并修订了几个已知皂苷的碳氢谱数据,在此基础上,总结了这类皂苷的波谱规律。本文同时讨论了这些皂苷及其类似物的细胞毒活性和其它活性。  相似文献   
9.
《Pharmaceutical biology》2013,51(10):1549-1554
Abstract

Context: Caesalpinia sappan Linn. (Leguminosae) has been used in folk medicines for the treatment of many diseases. The heartwood of this plant contains various phenolic components with interesting biological applications; however, the chemical and biological potentials of the seed of this plant have not been fully explored.

Objective: This study identified the cytotoxic activity of compounds from the seeds of C. sappan.

Materials and methods: The methanol extract of the seed of C. sappan was suspended in H2O and then partitioned with CH2Cl2, EtOAc, and n-BuOH, successively. Diterpenoid compounds were isolated from the CH2Cl2-soluble fraction by silica gel column chromatography methods using organic solvents. The compound structures were determined by detailed analysis of NMR and MS spectral data. Cytotoxic activity was measured using a modified MTT assay against HL-60, HeLa, MCF-7, and LLC cancer cells. The activation of caspase-3 enzyme and western blotting assay were performed to confirm inhibitory mechanism of active compound.

Results: Five cassane-type diterpenoids were isolated and identified as phanginin I (1), phaginin A (2), phanginin D (3), phanginin H (4), and phanginin J (5). Compounds 14 showed effective inhibition against HL-60 cells with the IC50 values of 16.4?±?1.5, 19.2?±?2.0, 11.7?±?1.6, and 22.5?±?5.1?μM. Compounds 13 exhibited cytotoxic activity against HeLa cells with the IC50 values of 28.1?±?3.6, 37.2?±?3.4, and 22.7?±?2.8?μM. Treatment of HL-60 cell lines with various concentrations of 3 (0–30?μM) resulted in the growth inhibition and induction of apoptosis.

Conclusion: These findings demonstrate that compound 3 (phanginin D) is one of the main active components of the seed of C. sappan activating caspases-3 which contribute to apoptotic cell death.  相似文献   
10.
Three new phenolic compounds (13) were isolated from the heartwood of Dalbergia odorifera T. Chen. (Leguminosae). Their structures were established based on spectroscopic methods including 1D and 2D NMR (HSQC, COSY, HMBC and ROESY). Compound 2 exhibited cytotoxicity against BEL-7402 tumor cell lines.  相似文献   
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