排序方式: 共有34条查询结果,搜索用时 15 毫秒
1.
目的 研究注射用米铂的配方及冻干生产工艺。方法 通过冻干溶剂的选择、原料溶解度试验、处方筛选、预冻工艺研究等确定注射用米铂配方和冻干工艺参数的控制范围。结果 确定冻干溶剂采用叔丁醇和环己烷的混合溶剂,环己烷最佳比例范围为10%~30%,药物浓度最佳范围为5~25 mg·mL-1,确定冻干工艺采用阶段性预冻方式。结论 选定的配方和工艺可行,自研制剂与参比制剂质量等同,节约了工艺生产成本。 相似文献
2.
采用NCG工业新型苯加氢催化剂(Ni/Al2O3),通过消除外扩散和内扩散影响,在反应温度433~473 K和氢压0.6~3.3 MPa下,对液相苯催化加氢制环己烷的反应动力学进行了研究。结果表明,液相反应中苯的反应级数为0,氢的反应级数几乎为1,因此氢在催化剂内的传质过程是形成内扩散阻力的主要原因。由内部效率因子和Thiele模数可知,粒径小于0.150 mm时才能消除内扩散影响,说明该催化剂具有较高本征反应活性。通过Thiele模数的定义式,求得氢液相有效扩散系数。由Wilke-Chang方程得到综合扩散系数,进而通过Thiele模数定义式求得催化剂曲节因子为3.12。通过模拟得到液相中氢在不同粒径颗粒内的浓度分布曲线,说明氢的内扩散阻力是苯加氢反应的控制因素。 相似文献
3.
目的建立工作场所空气中甲基环己烷的气相色谱测定方法。方法按照《工作场所空气中有毒物质检测方法研究规范》的要求进行实验室实验及现场实验。结果100nag活性炭对甲基环己烷的穿透容量大于15.05nag,当甲基环己烷的浓度为21.8~127mg/m^3时,采样效率均达99.63%-100%;样品在炭管中至少可保存8d,方法的重现性好,不同浓度的相对标准偏差为4.4%-8.4%;平均解吸效率为91.8%-97.4%;方法的最低检测浓度为0.13mg/m^3;空气中与甲基环己烷共存的苯、甲苯、正己烷、正庚烷等在该方法条件下不干扰测定。结论该方法各项指标均达到《工作场所空气中有毒物质检测方法研究规范》的要求,适用于工作场所空气中甲基环己烷的现场监测。 相似文献
4.
5.
d,l-Camphor was detected as a new inducer of hydroxylase in the liver musomes of female mice. After a 2-day inhalation of d,l-camphor, cyt. P-450 and the ethylumbelliferone dealkylase were increased by 250 per cent and the NADPH-cyt. P-450 reductase by 350 per cent. The product [NADPH-cyt. P-450 reductase activity × cyt. P450 concentration] was shown to be a suitable reference parameter for the ethylumbelliferone dealkylase activity in the liver musomes during the treatment with four different inducers. The relative dealkylase activity Q was much decreased during inhalation of cyclohexane or d,l-camphor.Obviously these two inducers preferably enhanced cyt. P-450 species with a low dealkylase activity. The Q-values were reproducible. Q was increased by 100 per cent during induction of a MC-sensitive mouse strain with 3-methylcholanthrene, but it was only moderately decreased by induction with phenobarbital. Corresponding to this, methylcholanthrene is known to selectively induce a cyt. P-448 with high dealkylase activity whereas phenobarbital is known to change the hydroxylase specificity in the liver musomes not very much. 相似文献
6.
7.
Novel 1,1-disubstituted cyclohexane-1-carboxamides 6a-h , 7a-e , and 8a-b were designed and synthesized as apoptotic inducers. Cytotoxicity test revealed that some compounds have strong to moderate effect, while others displayed weak action against different cancer cell lines including, MCF-7, HepG2, A549, and HTC-116. A549 carcinoma cell line exhibited higher sensitivity toward all synthesized candidates especially compounds 6a and 8a which offered the lowest IC50 values 3.03 and 5.21 μM, respectively, relative to the positive control doxorubicin with IC50 value of 3.01 μM. Compared to doxorubicin treatment, compounds 6a and 8a induced caspases-3, -8, and -9 activities and G2/M growth arrest in A549 carcinoma cell line. The expression levels of p53 (tumor suppressor protein that in humans is encoded by the TP53 gene), Bax (apoptosis regulator protein in humans that is encoded by bax gene), and the Bax/Bcl-2 ratio were all higher than those in doxorubicin-treated cells (Bcl-2, B-cell lymphoma 2, encoded in humans by the Bcl-2 gene). Additionally, compounds 6a and 8a appeared to exhibit higher selectivity against MCF-10 human breast normal cell line. The synthesized congeners could be considered as potent apoptotic inducers interfering with extrinsic and intrinsic apoptotic pathways. Moreover, compound 6a was able to form complex with zinc ions as indicated by UV spectrophotometry which revealed its ability for being caspase activator. Molecular docking studies expected the interactions and binding modes of the synthesized inhibitors in the caspase-3 active site. 相似文献
8.
研究了用于挥发性有机化合物催化燃烧的金属与催化层一体化催化剂,探讨了孔径对催化剂性能的影响。根据Langm uir吸附理论,建立了催化燃烧反应动力学模型,得到了甲苯、二甲苯、环己烷在空气中催化燃烧反应动力学方程。 相似文献
9.
10.
采用Pd/γ-Al2O3催化剂,在排除扩散影响的条件下,研究了液相苯催化加氢制环己烷的反应动力学。实验测定了反应温度、氢气压力、反应物浓度等因素对反应速率的影响,反应温度研究的范围为393~453K,氢气压力为1.1~3.8MPa。研究结果表明,液相苯加氢反应对苯表现为零级,对氢压表现为一级,反应活化能为43.88kJ/mol。运用该动力学模型对在较低苯浓度下进行的加氢反应进行了预测,预测值与实验值能较好地吻合。 相似文献