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排序方式: 共有222条查询结果,搜索用时 15 毫秒
1.
目的 研究溃疡宁对压疮的治疗效果.方法 将67例Ⅲ~Ⅳ期压疮患者,随机分为治疗组和对照组,治疗组34例压疮创面50处,在常规护理基础上加用院内制剂溃疡宁油纱条外敷换药,对照组33例压疮创面55处,在常规护理基础上加用0.1%利凡诺溶液纱布外敷换药,观察2组治疗30 d后压疮的总有效率.结果 治疗组总有效率为88.00%,对照组为61.18%,2组比较,差异有统计学意义(P<0.01).结论 自制溃疡宁治疗压疮,可减少伤口渗出,消炎消肿、收敛生肌、促进上皮生长,加快伤口愈合.  相似文献   
2.
Background: There are few published studies addressing multiple substance uses and their effects on subsequent cessation of betel quid (BQ) chewing in the Asia Pacific region. Objectives: This study aims to investigate the usage patterns of BQ chewing, cigarette smoking, and alcohol drinking, and their correlates with subsequent BQ cessation among a male inmate population. Methods: Data from 473 male inmates with a history of BQ use who were incarcerated in Taiwan Kaohsiung Prison was used for this analysis. Participants were asked to report their lifetime usage patterns of cigarette, alcohol, and BQ, and their cessation status of each substance. A stepwise logistic regression analysis was performed to identify predictors of voluntary BQ cessation. Results: Seventy-five percent of all participants reported habitual use of all three substances. A total of 185 (39%) participants reported voluntary cessation of BQ prior to incarceration, and 288 (61%) reported cessation because of incarceration. Inmates who quit smoking before incarceration were more likely to voluntarily quit BQ. Inmates who had drinking habits were less likely to quit BQ, but those who quit drinking before incarceration were more likely to quit BQ. Inmates who preferred the type of BQ known as lao-hwa quid were more likely to quit BQ, and a longer chewing history correlated with a lower likelihood of quitting BQ. Conclusions Importance: Our data suggest that coexisting habitual use of cigarette, alcohol, and BQ is very common in this inmate population. BQ cessation is significantly associated with not only inmates' usage patterns of cigarette and alcohol, but also their cessation status of these substances.  相似文献   
3.
目的:确定儿茶青黛口腔溃疡复合膜的制备工艺,并筛选出最佳配方。方法:通过制备方法设计分层制膜,并以黏附力、溶解时间、膜溶解时黏度、成膜性、韧性及药效学研究作为指标进行综合评价,筛选出复合膜最佳配方。结果:每200 cm2为标准,儿茶0.8 g,青黛0.8 g、PVA-1750 1.5 g、羧甲基纤维素钠1.2 g、甘油3.2 mL的配方为最佳配方。结论:根据试验筛选的方案制备的复合膜,在黏附力、溶解时间、膜溶解时黏度、成膜性、韧性及药效学研究方面符合要求,确定了儿茶青黛口腔溃疡复合膜的最佳制备工艺。  相似文献   
4.
Dengue virus (DENV) infection has become a critically important globally prevalent infectious disease, especially in tropical and subtropical countries. Since neither currently exists, there is an urgent need for an effective vaccine to prevent, and a specific drug to treat DENV infection. Therapeutic peptides represent an attractive alternative for development into anti-DENV drugs due to their safety and their diverse biological and chemical properties. We recently reported novel bioactive peptides extracted from the Asian medicinal plant Acacia catechu that efficiently inhibited all four DENV serotypes. In this study, we investigated the anti-DENV activity of a synthetic bioactive peptide derived from this plant. The most effective peptide (designated Pep-RTYM) inhibited DENV infection with a half-maximal inhibition concentration value of 7.9 μM. Time-of-addition study demonstrated that Pep-RTYM interacted with DENV particles and inhibited cellular entry. Pep-RTYM at 50 μM significantly reduced DENV production in Vero-kidney epithelial cells about 1000-fold, but it could decrease the virus production in Huh7 hepatocyte cells approximately 40-fold. Binding of Pep-RTYM to DENV particles may prevent virus interaction with cellular receptor and subsequent virus entry. This finding suggests a potential role of Pep-RTYM in the development of a novel anti-DENV drug.  相似文献   
5.
6.

Objective

Angelica archangelica Linn. is widely used in food and liquor preparations and also in Kashmiri folk medicine to reduce anxiety. We evaluated the anxiolytic effect of successive extracts of A. archangelica linn. (SAE) on rats tested in the elevated T-maze test (an animal model of generalized anxiety) at doses that exhibit antidepressant-like activity in humans.

Methods

A. archangelica (1 kg) was subjected to successive extraction in a soxhlet apparatus with solvents [petroleum ether (40–60° C), chloroform, ethyl acetate, methanol and decoction with water] in order of increasing polarity (yield: 6.9%, 7.3%, 5.1%, 11.88% and 8.2% w/w, respectively). SAE were evaluated for anxiolytic effects using the elevated T-maze and forced swimming tests in rats.

Results

Oral dosing of diazepam (1 mg/kg) and extracts (50, 100 and 200 mg/kg) clearly showed an anxiolytic-like profile in the elevated T-maze test: it increased one-way escape and decreased inhibitory avoidance on the first, third and seventh day. In the forced swimming test, imipramine and SAE showed antidepressant- and anxiolytic-like effects as reflected by increased climbing time, swimming time and decreased immobility time on the first, third and seventh day. Aqueous and methanol extracts showed the most, petroleum ether (40–60°C) and chloroform intermediate, and ethyl acetate the least anxiolytic activity (*P<0.05, **P<0.01, ***P< 0.001) in both models.

Conclusions

These results suggest the anti-anxiety activity of various extracts of A. archangelica and strongly justify its use in traditional Indian medicine for the treatment of anxiety.  相似文献   
7.
于辉  吕瑞芳  秦博文  陈超 《河北医学》2013,(12):1923-1925
目的:建立测定芦笋中硒含量的方法。方法:采用硝酸一高氯酸微波消解后,在铁氰化钾一盐酸体系中,选用最佳氢化物发生原子荧光法测定条件,采用标准曲线法定量分析。结果:该法线性范围为0—0.8μg,/mL,检出限为0.024μg/mL,回收率为96.7-103.3%,相对标准偏差为1.28%。结论:本方法简单、准确,适用于芦笋中硒的含量测定。。  相似文献   
8.
Two new phenolic compounds, 5-hydroxy-2-[2-(4-hydroxyphenyl) acetyl]-3-methoxylbenzoic acid (1) and (2S,3S)-3,7,8,3′,4′-pentahydroxyflavane (2), were obtained from the aqueous extract of Acacia catechu, along with four known compounds identified as rhamnetin (3), 4-hydroxyphenyl ethanol (4), 3,3′,5,5′,7-pentahydroxyflavane (5), and fisetinidol (6). Their structures were determined on the basis of spectroscopic analysis. Free radical-scavenging activities of the new compounds were evaluated.  相似文献   
9.
《Pharmaceutical biology》2013,51(7):832-838
Context: Chinese patent medicine Si-Mo-Tang oral liquid preparation (SMT) is composed of Aucklandia luppa Decne (Compositae), Citrus aurantium Linn (Rutaceae), Lindera aggregata (Sims) Kosterm (Lauraceae), and Areca catechu Linn (Arecaceae). Studies of SMT have been impeded due to the lack of quality control methods.

Objective: This study aimed to simultaneously determine three alkaloids including synephrine, arecoline, and norisoboldine in SMT for the first time.

Materials and methods: A strong cation exchange (SCX) high performance liquid chromatography (HPLC) method was developed to simultaneously determine synephrine, arecoline, and norisoboldine in SMT, and was compared with ion-pairing chromatography using regular reversed-phase chromatography columns. System suitability parameters of synephrine, arecoline, and norisoboldine using the SCX chromatography column were investigated.

Results: Results demonstrated that good separations were achieved on an Agilent SCX (250?×?4.6?mm, 5 µm) column at 35°C. The mobile phase consisting of methanol-0.2% phosphoric acid was delivered at a constant flow of 1.0?mL min?1 and the eluent was monitored at 215?nm. The HPLC method showed good linearity for the examined concentration ranges of 2.55–255.0, 1.30–208.0, and 2.06–201.6 µg mL?1 for synephrine, arecoline, and norisoboldine, respectively. The limits of quantification (S/N?=?10) were 2.55, 1.30, and 2.06 µg mL?1, the limits of detection (S/N?=?3) were 1.53, 0.78, and 1.21 µg mL?1, and average recoveries were 98.99, 95.63 and 99.04%, respectively, for synephrine, arecoline, and norisoboldine.

Discussion and conclusion: This method has been successfully applied to determine synephrine, arecoline, and norisoboldine in Chinese patent medicine SMT.  相似文献   
10.
槟榔及其活性物质的研究进展   总被引:3,自引:0,他引:3  
大量的临床实践及研究表明槟榔具有驱虫、消积、利气利水、利湿除疸等功效.槟榔碱是其从棕榈科植物槟榔中提取的最主要的保健和药理活性成分,对人体功能也有着广泛的影响.近年来国内外学者对槟榔及槟榔碱的药理、生理作用、免疫等方面进行了大量的研究,现将槟榔及其活性成分研究进展进行综述.  相似文献   
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