倍骼生治疗颌骨囊肿术后骨缺损的临床研究

目的:观察应用生物活性骨修复材料倍骼生PerioGlas誖治疗颌骨囊肿术后的骨缺损情况,评价修复效果。方法:以26例颌骨囊肿住院病例作为实验组,应用PerioGlas誖充填术后死腔;另20例作为对照组,采用碟形手术加碘仿纱条填塞法消除死腔。术后随访1、3、6个月,以X线片平均灰度值比较其骨密度变化。结果:实验组与对照组术后1、3、6个月骨密度平均灰度值有显著性差异。结论:用倍骼生PerioGlas誖充填死腔术后反应小,成骨速度快,缩短成骨过程,有利于骨缺损区的快速修复,是一种较理想的骨缺损修复材料。     

Oral implants placed in bone defects treated with Bio‐Oss®, Ostim®‐Paste or PerioGlas: an experimental study in the rabbit tibiae

Objectives: To compare the histological features of bone filled with Bio‐Oss^®, Ostim‐Paste^® or PerioGlas placed in defects in the rabbit tibiae by evaluating bone tissue composition and the integration of titanium implants placed in the grafted bone. Material and methods: Two cylindrical bone defects, about 4 mm in diameter and 6 mm in depth, were created in the tibiae of 10 rabbits. The defects were filled with either Bio‐Oss^®, PerioGlas, Ostim^®‐Paste or left untreated, and covered with a collagen membrane. Six weeks later, one titanium sandblasted and acid‐etched (SLA) implant was inserted at the centre of each previously created defect. The animals were sacrificed after 6 weeks of healing. Results: Implants placed in bone previously grafted with Bio‐Oss^®, PerioGlas or Ostim^®‐Paste obtained a larger extent of osseointegration, although not statistically significant, than implants placed in non‐grafted bone. The three grafting materials seemed to perform in a similar way concerning their contribution towards implant osseointegration. All grafting materials appeared to be osteoconductive, thus leading to the formation of bridges of mineralized bone extending from the cortical plate towards the implants surface through the graft scaffold. Conclusions: Grafting with the above‐mentioned biomaterials did not add any advantage to the osseointegration of titanium SLA implants in a self‐contained defect.     

倍骼生在口腔种植体骨结合中的实验研究

目的探讨与评估倍骼生（PerioGlas）在种植体周骨缺损区对种植体骨结合的效应。方法采用自身对照,在6只成年杂种狗下颌骨下缘各植入4颗纯钛种植体（共24颗）并在种植体周造成缺损,左下颌2颗为实验组,在缺损处填入倍骼生和自体血混合物,右下颌2颗为对照组,在缺损处任其充满自体血。术后4,8,12周分别处死两只狗,先后行电镜观测．骨密度测定和组织学观察。结果4,8,12周时实验组种植体骨结合率均较对照组高,实验组和对照组有显著性差异;实验组骨缺损区新生骨密度比对照组高;实验组可见大量成骨细胞、骨细胞及新生骨小梁,新生骨组织较成熟,对照组成骨细胞少,骨小梁细而少,纤维组织多见。结论倍骼生具有促进新骨形成及种植体骨结合的效应。     

两种不同骨替代材料在上颌前牙区种植体周围骨缺损中的应用效果评价

目的 研究对比Bio-Oss&PerioGlas在上颌前牙区种植体周围骨缺损中的成骨能力及成骨效果.方法 选取上颌前牙区种植体周围骨缺损患者20例,共植入32枚种植体,分别植入Bio-Oss和PerioGlas两种骨替代材料,于术后6个月行种植体上部永久冠修复.手术完成后随访1年,统计种植体存留率.通过红色美学指数(PES)、边缘骨水平(MBL)、唇腭侧骨板宽度、患者满意度,评价种植修复后成骨能力及效果.结果 种植体存留率均为100％.软组织情况较好,PES差异无统计学意义.两种骨替代材料术后与术后6个月的唇腭侧骨板宽度改变量差异有统计学意义,术后6个月与术后12个月的唇腭侧骨板宽度改变量差异无统计学意义.两种骨替代材料的术后6～12个月的边缘骨水平改变量差异无统计学意义.结论 在上颌前牙区种植体周围骨缺损中,Bio-Oss和PerioGlas均具有良好的成骨能力及成骨效果,通过比较发现Bio-Oss吸收较慢,有利于唇侧骨壁宽度的维持,具有较好的美学效果.     

倍骼生用于牙槽骨量不足的同期牙种植修复的临床观察

目的:评估倍骼生用于骨量不足的牙种植术的临床效果。方法:对22例存在骨量不足的种植牙患者,在植入36颗种植体的同时,采用倍骼生恢复种植体周围的骨缺损。结果:22例中无一例出现手术切口感染及种植体脱落,6～8个月后X线检查提示种植体周围的骨结合好,修复效果好。结论:倍骼生可以较好的修复种植体周围的骨缺损,不但可以扩大种植牙的适应证,而且可以使种植体获得较好的轴向和位置。