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排序方式: 共有218条查询结果,搜索用时 15 毫秒
1.
Pure psychiatric presentation of the Lewy body disease is depression—an analysis of 60 cases verified with myocardial meta‐iodobenzylguanidine study 下载免费PDF全文
2.
Treatment of neuroblastoma in congenital central hypoventilation syndrome with a PHOX2B polyalanine repeat expansion mutation: New twist on a neurocristopathy syndrome 下载免费PDF全文
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Background: Clinical symptoms of Parkinson’s disease (PD) include not only motor distress, but also autonomic dysfunction. Objective: To study the characteristics of subclinical autonomic nervous dysfunction in de novo PD without orthostatic hypotension (OH). Methods: Autonomic nervous function including cardiac sympathetic gain was evaluated on the basis of cardiac radioiodinated metaiodobenzylguanidine (MIBG) uptake, the response to the Valsalva maneuver, and spectral analyses of the RR interval and blood pressure in 20 patients with de novo PD without OH. Results: Decreased cardiac MIBG uptake was found even in patients with PD without OH. Hemodynamic studies using the Valsalva maneuver revealed that patients with PD without OH had preserved baroreceptor reflex sensitivity in phase II and phase IV. Blood pressures normally responded in early and late phase II, but not in phase IV. Blood pressure recovery time was slightly reduced in patients with PD without OH when compared with the value in controls. The low frequency component of the RR interval and systolic blood pressure and the ratio of RR‐LF to RR‐HF in de novo PD without OH were significantly reduced when compared with the control values, whereas the high frequency component of the RR interval did not differ significantly. Conclusion: These results show that latent cardiac and vasomotor sympathetic dysfunction but not parasympathetic dysfunction is already present in early stage de novo PD, even without orthostatic hypotension. 相似文献
4.
Autonomic dysfunction is common in Lewy body disorders (Parkinson's disease, Dementia with Lewy Bodies, Pure Autonomic Failure, and REM sleep disorder). The loss of post‐ganglionic myocardial sympathetic nerve fibers is a prominent feature of autonomic dysfunction in such disorders. 123I‐metaiodobenzylguanidine (MIBG) scintigraphy that visualizes catecholaminergic terminals in vivo is a biomarker used to detect cardiac sympathetic degeneration. Abnormal MIBG uptake has been consistently reported in Lewy body disorders. Some studies agree in the notion that increasing bradykinesia is related with an incremental cardiac sympathetic denervation, whereas tremor is not closely linked to cardiac denervation. “Atypical” parkinsonian syndromes, including Multiple System Atrophy, Progressive Supranuclear Palsy, and others, show modest reductions of cardial MIBG uptake. MIBG scintigraphy is moderately sensitive and specific in differentiating Parkinson's disease from such syndromes. Conversely, its sensitivity and specificity might be better in cognitively impaired patients, helping differential diagnosis between Dementia with Lewy Bodies, and Alzheimer disease. Confounding factors (comorbidities, comedications) should be carefully controlled before analyzing MIBG scintigraphy. © 2009 Movement Disorder Society 相似文献
5.
Fabiana Novellino MD Gennarina Arabia MD MSc Antonio Bagnato MD Giuseppe Lucio Cascini MD Maria Salsone MD Giuseppe Nicoletti MD Demetrio Messina MD Maurizio Morelli MD Sandra Paglionico MD Laura Giofrè MD Antonino Restuccia MD Giusi Torchia PhD Francesca Condino PhD Aldo Quattrone MD 《Movement disorders》2009,24(15):2242-2248
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Extended Sedation With Continuous Midazolam or Dexmedetomidine Infusion for Young Children Receiving 131I‐MIBG Radiopharmaceutical Therapy for Advanced Neuroblastoma 下载免费PDF全文
8.
Olguntürk R Turan L Tunaoglu FS Kula S Gökçora N Karabacak NI Azizoglu F 《Pacing and clinical electrophysiology : PACE》2003,26(10):1926-1930
The purpose of this study was to assess the left ventricular sympathetic nervous system function in the patients with neurocardiogenic syncope (NCS) using I-123 metaiodobenzylguanidine (MIBG) imaging of the heart, and to compare the plasma noradrenaline (NA) and MIBG results of tilt positive and tilt negative patients following a head-up tilt test (HUT). The study included 30 patients. Their physical and laboratory examinations did not show a pathology that may be the cause of their syncope. HUT test was positive in 13 patients and negative in 17 patients. Plasma NA concentrations were higher in the HUT positive than the HUT negative group at the beginning and at the 10th minute of the test. Specific I-123 MIBG uptake assessed as the cardiac to mediastinal activity ratio in the delayed image was significantly higher in HUT positive group. The higher levels of MIBG uptake and plasma NA observed in HUT positive patients may reflect the greater capacity of NA storage in cardiac adrenergic neuronal tissue in patients with NCS. The results of this study support the critical role of autonomic nervous system in the pathophysiology of NCS and the excessive sympathetic nervous stimulation as the trigger of paradox reflex. 相似文献
9.
Zhiming Chen Gang Wang Minhao Xie Heyun Huang Erming Wu Yang Wang 《Journal of labelled compounds & radiopharmaceuticals》2018,61(2):107-111
We have developed a new set of lyophilized kits, composed of 3 different kits, for the instant preparation of no‐carrier‐added 131I‐MIBG in the clinic. We here discussed the formulation of the kits, optimization of radiolabelling, quality control of radiolabeled 131I‐MIBG, and studies of animal biodistribution. The no‐carrier‐added (nca) 131I‐MIBG injection could be prepared within 30 minutes in the clinic with the help of the lyophilized kits. The radiochemical purity and specific activity (SA) could achieve above 98% and 6700 MBq/mg, respectively. 相似文献
10.
目的:探讨肥厚性心肌病的肥厚心肌与非肥厚心肌交感神经活性。方法选择18例肥厚性心肌病(HCM)患和6例对照(N组)。根据超声心动图将HCM组分为心尖部肥厚性心肌病(APM)5例,非对称性心室间隔肥厚性心肌病(ASH)7例,弥漫性肥厚性心肌病(DPM)6列。所有患均进行超声心动图(M型和B型)检查^201Tl和^123I-间碘苄胍(MIBG)显像。结果HCM组^123I-MIBG显像与N组相 相似文献