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排序方式: 共有1523条查询结果,搜索用时 171 毫秒
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2.
色甘酸钠混悬气雾剂与茶碱缓释胶囊治疗中度哮喘的比较 总被引:1,自引:1,他引:0
84例中度哮喘病人分成2组。色甘酸钠组(男性23例,女性20例,年龄26±s8a)吸入色甘酸钠混悬气雾剂10.5mg,tid。茶碱缓释胶囊组(男性22例,女性19例,年龄27±8a)口服0.25g。bid。2组均连续观察3mo。结果:色甘酸钠在减轻病人慢性症状、改善肺功能和降低气道高反应性等方面优于茶碱缓释胶囊,(P<0.01)。而后药仅可缓解近期症状。 相似文献
3.
Hideo Kanauchi Sadao Imamura Masahiro Takigawa Fukumi Furukawa 《The Journal of dermatology》1994,21(12):935-939
Kampo, a Japanese-Chinese traditional herbal medicine, has been used for the treatment of various diseases for about 3,000 years in China. Among herbal medicines, Sairei-to is well known for improving the symptoms of rheumatoid arthritis (RA) and other collagen diseases. However, its immunosuppressive effects on autoimmune cutaneous phenomena are not completely understood. We investigated the effects of Sairei-to on the development of lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mice, an animal model which spontaneously develops skin lesions similar to those seen in human lupus erythematosus. Virgin female MRL/lpr mice at 1 month of age, which were treated orally with Sairei-to, had reduced amounts of IgG deposition at the dermoepidermal junction, titers of anti-DNA antibodies and rheumatoid factor, and lymphoproliferation. These results support the use of traditional herbal medicines in patients with human RA and systemic lupus erythematosus. 相似文献
4.
Manis PB Molitor SC Wu H 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,153(4):443-451
During intracellular recordings in rodent brainstem slice preparations, dorsal cochlear nucleus (DCN) pyramidal cells (PCs) exhibit characteristic discharge patterns to depolarizing current injection that depend on the membrane potential from which the responses are evoked. When depolarized from hyperpolarized potentials, PCs can respond with a short-latency action potential followed by a long silent interval (pauser) or a train of action potentials with a long latency (buildup). During the silent intervals in a pauser or a buildup response, the membrane potential slowly depolarizes towards spike threshold, often exhibiting distinct voltage oscillations of 1–2 mV before the first spike. The subthreshold voltage oscillations were investigated using whole cell recordings from DCN PCs in rat pup (P10–14) brainstem slices. The oscillations were unaffected by excitatory and inhibitory neurotransmitter antagonists, and were not temporally locked to the onset of the depolarization. The oscillations typically became larger as spike threshold was approached, and had a characteristic frequency between 40 and 100 Hz. In the presence of tetrodotoxin (TTX, 500 nM), the oscillations were significantly suppressed, and could not be evoked at any voltage below or above spike threshold. The oscillations were not blocked by phenytoin or Cd2+, but they were affected by prior activity in the neuron for approximately 1 s. We conclude that voltage-gated Na+ channels are required to generate membrane oscillations during the buildup phase. We suggest that the subthreshold oscillations play a role in controlling spike timing in PCs when the membrane potential slowly approaches, or hovers near, spike threshold. 相似文献
5.
The IgG subclasses of immunoglobulin for intravenous injection (IVIg) were investigated after various different types of treatment.
The level of IgG2 was relatively low in preparations treated with pepsin, but by changing the clone producing anti-IgG2 antibody,
the level approached that of normal human serum. Though undetectable in sulfonated immunoglobulin preparations, IgG3 was detected
after reoxidation. When determining the IgG subclasses of IVIg, it must be kept in mind that the apparent value may subsequently
become lower due to the depressed reaction of the antibody. 相似文献
6.
Chekhonin VP Lebedev SV Dmitrieva TB Blinov DV Lazarenko IP Savchenko EA Volodin NN 《Bulletin of experimental biology and medicine》2002,133(6):609-613
Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis of apomorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy of cell preparations from 8- and lower from 16-17-day-old embryos. These data correlated with histomorphological findigs, in particular, with the size of grafts, glial reaction, and the number of dopaminergic neurons in the grafts. 相似文献
7.
R. Kurth I. Schmidt A. Werner G. von Wangenheim J. Löwer H. -D. Brede 《Journal of molecular medicine (Berlin, Germany)》1986,64(8):386-388
Summary Samples of 96 polyvalent and virus-specific immunoglobulin batches commercially available in West-Germany were tested by enzyme-linked immunoassay and immunoblot for the presence of anti-HTLV-III antibodies. 37% of the polyvalent and 87% of the virus-specific batches were positive. It was concluded that these preparations are still safe and because of their reportedly low titer neutralizing antibodies possibly beneficial in certain cases, such as newborns of HTLV-III positive mothers or after accidental exposure to infectious material in clinics or laboratories.Abbreviations AIDS
acquired immunodeficiency syndrome
- ARC
AIDS-related complex
- CMV
cytomegalovirus
- ELISA
enzyme-linked immuno adsorbent assay
- HTLV-III
human T-cell lymphotropic virus, type III 相似文献
8.
Puttemans ML Dryon L Massart DL 《Journal of pharmaceutical and biomedical analysis》1985,3(6):503-510
Synthetic dyes were extracted from syrups, oral suspensions, tablets, gelatin capsules, suppositories and granules by ion-pair formation with tri-n-octylamine (TnOA) and back-extracted with perchlorate ions. Identification was performed by TLC on cellulose layers and by reversed phase ion-pair HPLC. 相似文献
9.
Alberti MB Pinzauti S Moneti G Agati G Giannellini V Coran SA Vincieri FF 《Journal of pharmaceutical and biomedical analysis》1984,2(3-4):409-415
The medicinally important quaternary ammonium salts benzyldimethyltetradecylammonium chloride (BDTA), cetylpyridinium chloride and benzethonium chloride, all afford, under fast atom bombardment (FAB) mass spectrometric conditions, abundant and persistent [M---Cl]+ species usefully amenable to quantitative analysis with the aid of thioglycerol as a liquid FAB matrix. The use of BDTA as an internal standard allowed a direct, precise and accurate determination of cetylpyridinium and benzethonium chlorides, either as pure samples or in dosage forms, in the concentration range 0.05–2 mg/ml. 相似文献
10.
盐酸氨溴索缓释胶囊的三维释放特性及其体内外相关性的 … 总被引:5,自引:0,他引:5
目的:评价自制盐酸氨溴索(Amb)缓释胶囊的体外质量,并研究人体内吸刷与体外释放的相关性。方法:采用转法考察转速对释放度的影响。常温留样和加速实验观察制剂稳定性,并进行PH时间的三维释放实验和健康人体内单剂量生物利用度实验,计算累积释药分数并根据Wagner-Nelson法计算体内药物吸收分数,经回归显示相关性。结果:Amb缓释胶囊释药受介质PH影响较小,且不受转速的影响。制剂贮存3个月,质量稳定 相似文献