排序方式: 共有36条查询结果,搜索用时 406 毫秒
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目的:观察愈美颗粒治疗小儿急性支气管炎的临床疗效及安全性.方法:156例急性支气管炎患儿随机分为两组,对照组予常规抗感染及雾化吸入等治疗,观察组加用愈美颗粒治疗.比较两组患儿咳嗽、咳痰和痰液黏稠度等临床症状改善率和总有效率,并观察药品不良反应.结果:观察组治疗后临床症状评分显著优于对照组(P<0.05).观察组临床控制率52.56%,总有效率89.74%,均明显高于对照组(P<0.05),且未发生明显药品不良反应.结论:愈美颗粒能有效辅助治疗小儿急性支气管炎,安全性好,值得临床推广使用. 相似文献
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用紫外双波长系数倍率法测定愈创木酚甘油醚(GF)在家兔体内的血药浓度。含药血浆用无水乙醇沉淀提取,测定波长为274nm和291nm。以200mg/kg的剂量给家兔灌胃后,耳缘静脉取血样测定GF的血药浓度,Cmax为94.85μg/ml,达峰时间(Tp)为0.5h。用PKBP-N1程序中单室模型一级吸收拟合,所得结果Tp为0.432h,Cmax为96.73μg/ml,半衰期t1/2为0.963h;模拟值与实测值的相关系数为0.999。 相似文献
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目的研究分析氨咖愈敏溶液含量测定方法,优化色谱分离条件。方法采用C18柱,流动相为磷酸二氢铵溶液-乙腈-甲醇(70:10:20),检测波长为271nm,测定对乙酰氨基酚、愈创甘油醚、无水咖啡因含量;采用C18柱,流动相为磷酸二氢铵缓冲液(0.1%三乙胺)-乙腈(73:27),检测波长为221nm,测定马来酸氯苯那敏含量。结果对乙酰氨基酚、愈创甘油醚、咖啡因分别在0.03051~0.3051mg/ml(r=1)、0.009748~0.09748mg/ml(r=1)、0.003838~0.03838mg/ml(r=1)与峰面积有良好的线性关系,平均回收率分别为101.5%、100.6%、100.7%(n=9),马来酸氯苯那敏在0.003968~0.03968mg/m](r=1)与峰面积有良好的线性关系,平均回收率为100.1%(n=9)。结论该方法操作简便、准确、重复性好,可用于氨咖愈敏溶液的质量控制。 相似文献
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目的:建立氢溴酸右美沙芬愈创甘油醚干混悬剂的含量测定方法。方法:采用高效液相色谱法,选用Diamonsil C_(18)色谱柱(4.6mm×15cm),流动相:0.075mol·L~(-1)磷酸三乙胺溶液(pH2.8±0.2)-乙腈(75∶25);流速:1.0ml·min~(-1),检测波长:280nm。结果:氢溴酸右美沙芬在25.0~125.0μg·ml~(-1),愈创甘油醚在167.6~838.2μg·ml~(-1)的浓度范围内,面积与浓度呈良好的线性关系。氢溴酸右美沙芬愈创甘油醚干混悬剂方法回收率分别为100.6%,99.4%,RSD分别为0.81%,0.46%。结论:方法准确、灵敏、可靠,适用于氢溴酸右美沙芬愈创甘油醚干混悬剂的含量测定。 相似文献
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目的:建立以反相高效液相色谱法测定小儿咳喘口服液中氨茶碱、麻黄碱和愈创木酚甘油醚含量的方法。方法:色谱柱为Hypersil ODS(150mm×4.6mm,5μm),流动相为乙腈∶0.015mo·lL-1磷酸二氢钾溶液(含0.1%三乙胺,磷酸调pH2.7)=10∶90,检测波长为254、209nm,流速为1.6mL·min-1。结果:氨茶碱、麻黄碱、愈创木酚甘油醚的检测浓度分别在356.4~712.8、88~176、106~212μg·mL-1范围内与各自峰面积积分值呈良好的线性关系(r均为0.9999);平均回收率分别为101.0%、99.7%、98.3%,RSD分别为0.73%、1.00%、0.44%(n均为9)。结论:本法简便、准确,可用于小儿咳喘口服液的质量控制。 相似文献
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目的:愈美颗粒剂佐治小儿肺炎临床疗效观察。方法:将 160例肺炎患儿随机分为对照组40例和治疗组120例,对照组按常规治疗,治疗组在常规治疗同时,加用愈美颗粒剂,按常规剂量服用。结果:退热时间、止咳时间、肺部罗音消失时间,治疗组优于对照组(P<0.01)。结论:愈美颗粒剂佐治小儿肺炎临床疗效良好。 相似文献
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The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films 总被引:4,自引:0,他引:4
Michael M Crowley Anke Fredersdorf Britta Schroeder Shawn Kucera Suneela Prodduturi Michael A Repka James W McGinity 《European journal of pharmaceutical sciences》2004,22(5):409-418
Films containing polyethylene oxide (PEO) and a model drug, either guaifenesin (GFN) or ketoprofen (KTP), were prepared by hot-melt extrusion. The thermal properties of the hot-melt extruded films were investigated using differential scanning calorimetry (DSC). Scanning electron microscopy (SEM) was used to examine the surface morphology of the films, and wide angle X-ray diffraction (XRD) was used to investigate the crystalline properties of the polymer, drugs and physical mixtures as well as the solid state structure of the films. The stability of the polymer was studied using gel permeation chromatography. The mechanical properties, including percent elongation and tensile strength of the films, were determined on an Instron according to American Society for Testing Materials (ASTM) procedures. The Hansen solubility parameter was calculated using the Hoftyzer or van Krevelen method to estimate the likelihood of drug–polymer miscibility. Both GFN and KTP were stable during the extrusion process. Melting points corresponding to the crystalline drugs were not observed in the films. Crystallization of GFN on the surface of the film was observed at all concentrations studied, however KTP crystallization did not occur until reaching the 15% level. Guaifenesin and ketoprofen were found to decrease drive load, increase PEO stability and plasticize the polymer during extrusion. The Hansen solubility parameters predicted miscibility between PEO and KTP and poor miscibility between PEO and GFN. The predictions of the solubility parameters were in agreement with the XRD and SEM results. The percent elongation decreased with increasing GFN concentrations and significantly increased with increasing levels of KTP. Both GFN and KTP decreased the tensile strength of the extruded film. 相似文献
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目的:建立高效液相色谱法测定氯化铵甘草口服溶液中吗啡、愈创甘油醚和甘草酸的含量方法。方法采用C8和C18柱,流动相为0.05 mol/L磷酸二氢钾溶液-0.0025 mol/L庚烷磺酸钠溶液-乙腈,流速为1.0 ml/min,柱温为35℃,检测波长分别220 nm和260 nm。结果吗啡、愈创甘油醚和甘草酸分别在2.0~20.2、20.3~203.0、10.0~100.0μg/ml范围内呈现良好的线性关系,平均加样回收率分别为99.4%、100.4%、101.1%。结论该方法快速、准确、重复性好,适用于氯化铵甘草口服溶液中吗啡、愈创甘油醚和甘草酸的检测和质量控制。 相似文献
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