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1.
目的完善酚氨咖敏颗粒的质量标准。方法采用薄层色谱(TLC)法对乙酰氨基酚、氨基比林、咖啡因及马来酸氯苯那敏进行定性鉴别。采用气相色谱(GC)法同时测定4种成分的含量,色谱柱为TR-1弹性石英毛细管柱(30 m×0. 32 mm,0. 25μm),程序升温(起始温度为180℃,保持1 min,再以8℃/min的速率升至240℃,保持2 min),氢火焰离子化检测器温度为260℃。结果 TLC法可同时鉴别酚氨咖敏颗粒中4种成分。对乙酰氨基酚、氨基比林、咖啡因及马来酸氯苯那敏质量浓度线性范围分别为186. 3~5 960μg/m L(r=0. 999 9),124. 9~3 996μg/m L(r=0. 999 9),38. 24~1 224μg/m L(r=1. 000 0)和2. 525~80. 80μg/m L(r=0. 999 9);平均加样回收率分别为98. 69%,99. 45%,99. 52%,101. 40%,RSD分别为1. 36%,1. 62%,1. 20%,1. 25%(n=9)。结论该方法简便快速、准确可靠,适用于酚氨咖敏颗粒中4种成分的定性、定量分析,可更全面地控制该制剂的质量。  相似文献   
2.
目的:探讨高效液相色谱法(HPLC)测定酚氨咖敏片中马来酸氯苯那敏含量均匀度的方法。方法:采用HPLC,Alltima C18(4.6min×250mm,5μm);1%醋酸溶液(用二乙胺调节pH值至3.7)-甲醇(62:38)为流动相;检测波长260nm。结果:进样量在0.12-0.80μg与峰面积的线性关系良好(r=-0.9999);平均回收率为99.75%,99.90%,99.68%;RSD为0.42%,0.25%,0.70%(n=3),精密度、重复性良好。结论:所建方法准确、简便、快速,适用于酚氨咖敏片中马来酸氯苯那敏含量均匀度的测定。  相似文献   
3.
Since glutathione is thought to be involved in cerebral functions, changes in the glutathione level imply modulations of the neurotransmission in addition to all the known effects of GSH. It was investigated whether alterations of the cerebral glutathione can be induced by consumption of GSH, by inhibition or stimulation of the synthesis of GSH, or by an inhibition of the re-reduction of the oxidized glutathione. Aminophenazone, propyphenazone, acetaminophen, phenytoin, morphine and nitrofurantoin, known to deplete hepatic GSH, had no effects on cerebral GSH. Diethyl maleate (0.6 ml/kg) decreased the cerebral content of GSH and GSSG in adult rats as well as in fetuses. The depletion of the cerebral GSH caused by diethyl maleate treatment for 4 days was followed by an increase up to 125% and a subsequent return to the normal level after 1 week. In rats starved up to 71 h deficiency of exogenous amino acids caused only a minimal or no decrease in cerebral GSH. The specific inhibitor of the gamma-glutamylcysteine synthetase BSO only depleted GSH in the brain of young mice following the repeated s. c. administration of a high dose (890 mg/kg). After cobaltous chloride (20 mg/kg; twice a day for 2 or 4 days) the GSH level in the brain was unchanged. In vivo inhibition of the cerebral glutathione reductase was caused by ammonium metavanadate (12.5 mg/kg; three times a week for 6 weeks). Nitrofurantoin (150 mg/kg) had no effect. After lomustine (10 mg/kg) a minimal increase in glutathione reductase was found, but simultaneously also an increase in GSSG and of the ratio GSSG/total glutathione.  相似文献   
4.
The interference of central monoamine depletion with the anti-nociceptive effect of morphine, pethidine and aminophenazone was studied in rats with regard to the changes in spinal motor activity induced by reserpine, tetrabenazine and α-methyl-p-tyrosine.All three analgesic agents prolonged the time of the tail-flick reaction in intact rats. This effect was abolished by reserpine, which prolonged the reaction time. Bilateral lesioning of the substantiae nigrae with microinjections of 6-hydroxydopamine prolonged the reaction time and abolished the anti-nociceptive effect of morphine. In spinal rats, the time of the tail-flick reaction was prolonged by morphine and reduced by aminophenazone. Reserpine did not abolish the effect of morphine in spinal rats.Morphine, pethidine and aminophenazone inhibited the α-reflex discharges facilitated by conditioning stimulation in intact and spinal rats. Pethidine and aminophenazone, but not morphine, depressed the facilitation of α-reflex discharges produced by central monoamine depletion in intact rats. The increase in the amplitude of monosynaptic mass reflexes produced by reserpine in intact rats was not reduced by morphine, whereas the depression of polysynaptic mass reflexes after reserpine was antagonized by morphine.The three analgesic agents differ markedly in their action on spinal motor activity altered by monoamine depletion. It is concluded that the antagonizing effect of central monoamine depletion on the anti-nociceptive effect of morphine, pethidine and aminophenazone in the rat is due to a change in the basal motor activity on which the spinal nociceptive reflex is elicited.  相似文献   
5.
小儿酚氨咖敏颗粒含量测定方法改进研究   总被引:1,自引:2,他引:1  
赫晓军 《中国药事》2006,20(11):684-686
提高小儿酚氨咖敏颗粒含量测定质量标准,更有效的控制其含量.用HPLC法同时测定氨基比林、对乙酰氨基酚和咖啡因的含量.采用Diamonsal C18色谱柱,流动相为乙腈-0.05mol·L-1磷酸二氢钾溶液-三乙胺-磷酸(10∶90∶0.02∶0.03)(调节pH值为3.5),流速为1ml·min-1,检测波长215nm.线性关系与回收率氨基比林0.06~1.80μg(r=0.9999),101.22%(RSD=0.45%);对乙酰氨基酚0.075~2.25μg(r=0.9999),101.27%(RSD=0.51%);咖啡因0.02~0.6μg(r=0.9999),100.7%(RSD=0.70%).方法简便,准确,重现性好.  相似文献   
6.
目的:采用高效液相色谱法测定酚氨咖敏颗粒中马来酸氯苯那敏的含量均匀度。方法:采用十八烷基硅烷键合硅胶色谱柱,检测波长为224nm,流动相为乙腈0.3%十二烷基硫酸钠溶液一磷酸(60:40±0.02)(用三乙胺调pH值至3.3±0.1),流速为1.0mL/min,进样量为20ML,以外标法测定样品含量。结果:马来酸氯苯那敏在浓度5~100μg/mL范围内与峰面积线性关系良好,平均回收率为100.37%,RSD为0.53%。结论:该方法科学,重复性好,可用于酚氨咖敏颗粒中马来酸氯苯那敏含量均匀度的测定。  相似文献   
7.
万莉 《中国药师》2007,10(10):1001-1002
目的:建立复方金刚烷胺氨基比林片中氨基比林的含量测定HPLC法。方法:色谱柱Diamonsil C_(18)柱(250mm×4.6mm.5μm),流动相为甲醇-水(52:48),检测波长为272 nm,流速为1.0 ml·min~(-1)。结果:线性范围为0.37~2.25μg(r= 0.999 9),平均回收率为99.8%,RSD为0.5%(n=6)。结论:本方法简便准确、准确,重现性好,可用于复方金刚烷胺氨基比林片中氨基比林的含量测定。  相似文献   
8.
目的:建立氨酚比林注射液中对乙酰氨基酚、氨基比林含量的高效液相色谱方法。方法:选用AgilentSBC18(150 mm ×4.6mm,5μm),乙腈-0.1%磷酸溶液-三乙胺(12:87:1)为流动相,检测波长为240 nm,流速为1.0 ml·min-1。结果:对乙酰氨基酚的线性范围为0.35-1.74μg(r=0.999 9),平均回收率为101.4%,RSD=0.5%;氨基比林的线性范围为0.48~2.42 μg,r=0.999 9,平均回收率为100.3%,RSD=0.4%。结论:本方法快速、准确,样品处理简便易行。  相似文献   
9.
酚氨咖敏颗粒含量测定方法研究   总被引:3,自引:0,他引:3  
赫晓军  朱淑芳 《中国药业》2006,15(12):18-19
目的 提高酚氨咖敏颗粒含量测定质量标准,更有效地控制其含量。方法 用高效液相色谱法(HPLC法)同时测定酚氨咖敏颗粒中氨基比林、对乙酰氨基酚和咖啡因的含量。结果 氨基比林、对乙酰氨基酚、咖啡因的线性范围分别是0.06-1.80μg,0.075-2.25μg,0.02-0.6μg(r=0.9999,n=7),平均回收率分别为101.22%,101.27%,100.70%,RSD分别为0.45%,0.51%,0.70%。结论 方法简便,结果准确,重现性好,能有效控制该产品的质量。  相似文献   
10.
RP-HPLC法同时测定氨咖敏片中3组份的含量   总被引:1,自引:1,他引:1  
辛俊衡 《中国药师》2006,9(12):1119-1120
目的:建立用 RP-HPLC 法测定氨咖敏片中氨基比林、咖啡因和马来酸氯苯那敏含量的方法。方法:用 Kromasil C_(18)柱(250 mm×4.6 mm,5μm),以乙腈-0.3%十二烷基硫酸钠溶液-磷酸(60:40:0.02)(用三乙胺调 pH 至3.3)为流动相,流速1.0ml·min~(-1),检测波长215 nm。结果:氨基比林、咖啡因和马来酸氯苯那敏分别在30.2~90.5μg·ml~(-1)(r=0.999 9),2.8~8.4μg·ml~(-1)(r=0.999 6)和10.1~30.2μg·ml~(-1)(r=0.999 9)范围内呈线性关系,平均回收率分别为99.4%,RSD=0.3%(n=9),99.6%,RSD=0.5%(n=9)和99.3%,RSD 0.4%。结论:本法简单、快速和准确,适用于氨咖敏片质量控制。  相似文献   
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