全文获取类型
收费全文 | 24759篇 |
免费 | 1159篇 |
国内免费 | 513篇 |
专业分类
耳鼻咽喉 | 549篇 |
儿科学 | 878篇 |
妇产科学 | 366篇 |
基础医学 | 2599篇 |
口腔科学 | 370篇 |
临床医学 | 1538篇 |
内科学 | 4614篇 |
皮肤病学 | 878篇 |
神经病学 | 2180篇 |
特种医学 | 1219篇 |
外国民族医学 | 1篇 |
外科学 | 3630篇 |
综合类 | 1648篇 |
现状与发展 | 1篇 |
预防医学 | 614篇 |
眼科学 | 621篇 |
药学 | 3496篇 |
3篇 | |
中国医学 | 360篇 |
肿瘤学 | 866篇 |
出版年
2023年 | 125篇 |
2022年 | 328篇 |
2021年 | 520篇 |
2020年 | 352篇 |
2019年 | 540篇 |
2018年 | 660篇 |
2017年 | 593篇 |
2016年 | 470篇 |
2015年 | 443篇 |
2014年 | 738篇 |
2013年 | 1279篇 |
2012年 | 645篇 |
2011年 | 763篇 |
2010年 | 606篇 |
2009年 | 686篇 |
2008年 | 797篇 |
2007年 | 762篇 |
2006年 | 626篇 |
2005年 | 587篇 |
2004年 | 712篇 |
2003年 | 796篇 |
2002年 | 1428篇 |
2001年 | 1802篇 |
2000年 | 1973篇 |
1999年 | 1293篇 |
1998年 | 1254篇 |
1997年 | 1130篇 |
1996年 | 687篇 |
1995年 | 464篇 |
1994年 | 304篇 |
1993年 | 279篇 |
1992年 | 244篇 |
1991年 | 268篇 |
1990年 | 224篇 |
1989年 | 206篇 |
1988年 | 172篇 |
1987年 | 155篇 |
1986年 | 125篇 |
1985年 | 191篇 |
1984年 | 172篇 |
1983年 | 115篇 |
1982年 | 145篇 |
1981年 | 118篇 |
1980年 | 114篇 |
1979年 | 82篇 |
1978年 | 74篇 |
1977年 | 83篇 |
1976年 | 80篇 |
1975年 | 42篇 |
1974年 | 43篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
《Anaesthesia and Intensive Care Medicine》2020,21(11):572-577
Phaeochromocytomas and paragangliomas (PPGL) are catecholamine-secreting neuroendocrine tumours. These tumours may be identified incidentally, as part of a work-up for multiple endocrine neoplasia or following haemodynamic surges during unrelated procedures. Advances in preoperative management and improved management of intraoperative haemodynamic instability have significantly reduced surgical mortality from around 40% to less than 3%. Surgery is the definitive treatment in most cases and laparoscopic resection where possible is associated with improved outcomes. Anaesthetic management of PPGL cases represents a unique haemodynamic challenge both before, during and after tumour resection. In this article we describe the physiology of these tumours, their diagnosis, preoperative optimization methods, intraoperative anaesthetic management and management of postoperative complications. 相似文献
3.
4.
Alessandro Vatrella Angelantonio Maglio Corrado Pelaia Girolamo Pelaia Carolina Vitale 《Expert opinion on pharmacotherapy》2020,21(12):1505-1515
ABSTRACT
Introduction
‘Critical Asthma Syndrome’ (CAS) is an umbrella term proposed to include several forms of asthma, responsible for acute and life-threatening exacerbations. CAS requires urgent and adequate supportive and pharmacological treatments to prevent serious outcomes. 相似文献5.
6.
《Drug discovery today》2022,27(6):1733-1742
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are routinely encountered in assays at various stages of drug discovery. We observed that assays for the investigation of thiol-reactive and redox-active compounds have not been collected in a comprehensive review. Here, we review these assays and subject them to experimental optimization to improve their reliability. We demonstrate the usefulness of our assay cascade by assaying a library of bioactive compounds, chemical probes, and a set of approved drugs. These high-throughput assays should complement the array of wet-lab and in silico assays during the initial stages of hit discovery campaigns to pursue only hit compounds with tractable mechanisms of action. 相似文献
7.
8.
Ramya Deepthi Vinnakota Allan S. Brett 《The American journal of the medical sciences》2019,357(2):160-163
Iron deficiency anemia is often listed among potential adverse effects of gastric acid-suppressive medications, given that gastric acidity promotes intestinal absorption of nonheme iron. Additionally, the antacid calcium carbonate can inhibit iron absorption. However, there is little direct clinical evidence that proton-pump inhibitors, histamine-2 receptor antagonists, or calcium carbonate cause iron deficiency anemia. Most case reports have had substantial limitations (e.g., minimal follow-up and presence of other causes of iron deficiency), and retrospective cohort studies have lacked sufficient patient-specific detail to make strong causal inferences. We present 2 cases—both with detailed, prospective 10-year follow-up—in which combinations of proton-pump inhibitors, histamine-2 receptor antagonists and calcium carbonate were clearly associated with development of iron deficiency anemia. Overt iron-deficiency anemia is probably uncommon in patients who use acid-modifying medications and who have no other conditions that predispose to iron deficiency. Nevertheless, clinicians should be aware of this potential complication, given widespread use of these agents. 相似文献
9.
10.