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1.
Objective To study the expressive levels of galectin-3(gal-3) and sambucus nigra agglutinin (SNA) and their clinicopathological significance in the benign and malignant lesions of stomach. Methods EnVisonTM immunohistochemistry for assaying gal-3 expressive level and ABC cytochemistry for determining SNA expressive level were used in conventional paraffin-embedded sections from specimens of gastric cancer(n=49), peritumoral tissues(n=20), metastastic foci of lymph nodes(n=36), and different types of benign lesions(n=80). Results The positive rates of gal-3 and SNA were significantly higher in gastric cancer tissues than those in peritumoral tissues and different types of benign lesions (P<0.05, P<0.01). The positive cases of gal-3 and/or SNA in peritumoral tissues and benign lesions showed mild- to severe-atypical hyperplasia of mucous epithelial cells. No difference was found between the primary foci and metastatic foci in gal-3 and SNA expressions (P>0.05). The positive rates of gal-3 and SNA were significantly lower in histologic grade Ⅱ, infitrating depth T1,T2 and no-metastasis of regional lymph node than those in histologic grade Ⅲ, Ⅳ, infitrating depth T3,T4 and metastasis of lymph node in gastric cancer(P<0.05). The positive rates of gal-3 and SNA were higher in lymphnede metastatic site N1 and no-metastasis of distant organs than those in lymphnede metastatic site N2, N3 and metastasis of distant organs, but no significant difference was found (P>0.05). The consistence was found between the expression of gal-3 and SNA in gastric cancer tissues (χ2=6.59,P<0.05). Conclusions The expressive levels of gal-3 and SNA may be important molecular markers of lectins for reflecting the carcinogenesis, progression and biological behaviors in gastric cancer. 相似文献
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从忍冬科接骨木属植物接骨木Sambucuswilliamsii干燥茎枝乙醇提取物的石油醚和氯仿部分中分得6个单体化合物。通过化学方法和波谱分析鉴定其结构分别为:棕榈酸蛇麻脂醇酯(Ⅰ)、熊果酸(Ⅱ)、β-谷甾醇(Ⅲ)、α-香树脂醇(Ⅳ)、三十烷酸(Ⅴ)和β-谷甾醇-β-D-葡萄糖苷。以上化合物均为首次从该植物中分得。 相似文献
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THE BODY SHOP接骨木花眼胶在大S的《美容大王》里被推荐过,据说是戴安娜王妃生前最喜欢的一款东东,也是THE BODY SHOP卖的最好的产品之一。它在网络上得到了众多爱美MM的追捧,然而买到假货会让MM们痛心不已,现在“美粉”们不用担心了,小编这就带你火眼金睛辨假货! 相似文献
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目的:收集蒙药材接骨木研究的最新资料,为进一步开发研究接骨木提供依据。方法:查阅文献及最新报道,对蒙药材接骨木的化学成分,药理作用及营养进行综述。结果:查阅的资料全面、内容新颖、数据可靠,可做接骨木研究的参考资料。 相似文献
7.
金叶接骨木的生药学实验研究 总被引:1,自引:0,他引:1
目的:了解金叶接骨木生药学特征、主要化学成分,为金叶接骨木的鉴别和开发利用提供依据。方法:对金叶接骨木茎叶进行生药性状、显微和薄层色谱的鉴别研究。结果:生药学鉴别中可见单宁细胞、腺毛及油细胞等接骨木属显微特征;薄层色谱表明含有黄酮类成分槲皮素、芸香苷以及熊果酸、齐墩果酸等三萜类化学成分。结论:通过以上研究结果建立了有效的鉴别金叶接骨木的方法。 相似文献
8.
基于GC-MS分析接骨木3个品种果实中挥发油成分 总被引:1,自引:0,他引:1
目的:对接骨木3个品种(耐盐碱品种、天然红1号品种、青州15号品种)果实的挥发油成分进行研究。方法:采用水蒸气蒸馏法提取接骨木3个品种果实中的挥发油,利用气相色谱-质谱联用(GC-MS)分析挥发油样品中的成分,对比找出不同品种接骨木药材的特有成分。结果:耐盐碱品种果实分离出32个化合物,鉴定出30个化合物,21个特有成分;天然红1号品种果实分离出62个化合物,鉴定出34个化合物,32个特有成分;青州15号品种果实分离出26个化合物,鉴定出24个化合物,16个特有成分。结论:通过分析可找出不同品种接骨木的挥发油特征成分,为接骨木的开发利用提供实验资料。 相似文献
9.
Objective To study the expressive levels of galectin-3(gal-3) and sambucus nigra agglutinin (SNA) and their clinicopathological significance in the benign and malignant lesions of stomach. Methods EnVisonTM immunohistochemistry for assaying gal-3 expressive level and ABC cytochemistry for determining SNA expressive level were used in conventional paraffin-embedded sections from specimens of gastric cancer(n=49), peritumoral tissues(n=20), metastastic foci of lymph nodes(n=36), and different types of benign lesions(n=80). Results The positive rates of gal-3 and SNA were significantly higher in gastric cancer tissues than those in peritumoral tissues and different types of benign lesions (P<0.05, P<0.01). The positive cases of gal-3 and/or SNA in peritumoral tissues and benign lesions showed mild- to severe-atypical hyperplasia of mucous epithelial cells. No difference was found between the primary foci and metastatic foci in gal-3 and SNA expressions (P>0.05). The positive rates of gal-3 and SNA were significantly lower in histologic grade Ⅱ, infitrating depth T1,T2 and no-metastasis of regional lymph node than those in histologic grade Ⅲ, Ⅳ, infitrating depth T3,T4 and metastasis of lymph node in gastric cancer(P<0.05). The positive rates of gal-3 and SNA were higher in lymphnede metastatic site N1 and no-metastasis of distant organs than those in lymphnede metastatic site N2, N3 and metastasis of distant organs, but no significant difference was found (P>0.05). The consistence was found between the expression of gal-3 and SNA in gastric cancer tissues (χ2=6.59,P<0.05). Conclusions The expressive levels of gal-3 and SNA may be important molecular markers of lectins for reflecting the carcinogenesis, progression and biological behaviors in gastric cancer. 相似文献
10.
接骨木多糖对大鼠胰岛细胞增殖及胰岛素分泌的影响 总被引:1,自引:0,他引:1
目的探讨接骨木多糖对体外培养大鼠胰岛β细胞株INS-1E细胞增殖和胰岛素分泌的影响。方法采用CCK-8方法检测接骨木多糖对大鼠胰岛细胞活性影响以及对四氧嘧啶损伤后细胞活性的影响;采用ELISA法检测接骨木多糖联合四氧嘧啶对大鼠胰岛细胞分泌胰岛素功能的影响。结果接骨木多糖可以明显促进大鼠胰岛细胞增殖(P<0.05),并降低四氧嘧啶诱导的大鼠胰岛细胞损伤(P<0.05)、增加胰岛素分泌(P<0.05)。结论接骨木多糖对四氧嘧啶诱导的大鼠胰岛细胞损伤具有保护作用。 相似文献