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尹丹萍  柳林 《眼科新进展》2007,27(11):865-868
新近发现的Vasohibin是一个内皮组织衍生的可被血管内皮生长因子诱导的分泌性蛋白质,它是迄今为止发现的唯一以负反馈为作用机制调节血管新生的因子。它的发现证实在血管新生的过程中也存在经典的自身调节控制机制—负反馈调节。本文就Vasohibin的结构特点、生物活性及在抑制病理性血管新生中的作用做一综述。  相似文献
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Ischemic and neovascular diseases are one of the most difficult ocular diseases to deal with nowadays. Redundancy, poor visual acuity and decreased life quality are bothering patients and ophthalmologists for decades. After VEGF was found to be a primary factor in promoting retinal angiogenesis, intravitreal injection of anti-VEGF drugs has been the first-line treatment. Whereas, some patients are refractory to this therapy and problems of economic burden, local complications and adverse effects promote researches into other possible targets. The vasohibin (VASH) family is a newly-investigated factor in modulating ocular angiogenesis. The family includes VASH1 and VASH2, which show opposite effects of inhibiting and accelerating angiogenesis respectively. Positive results have been reported in cellular and animal experiments. With further researches, it can be a promising future target of treating ocular neovascular diseases.  相似文献
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