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《Saudi Pharmaceutical Journal》2022,30(6):669-678
BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction. 相似文献
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Guo-Quan Shi Huajun Zhu & Zhen-Guo Yan 《Communications In Computational Physics》2022,31(4):1215-1241
A priori subcell limiting approach is developed for high-order flux reconstruction/correction procedure via reconstruction (FR/CPR) methods on two-dimensional unstructured quadrilateral meshes. Firstly, a modified indicator based on
modal energy coefficients is proposed to detect troubled cells, where discontinuities
exist. Then, troubled cells are decomposed into nonuniform subcells and each subcell has one solution point. A second-order finite difference shock-capturing scheme
based on nonuniform nonlinear weighted (NNW) interpolation is constructed to perform the calculation on troubled cells while smooth cells are calculated by the CPR
method. Numerical investigations show that the proposed subcell limiting strategy on
unstructured quadrilateral meshes is robust in shock-capturing. 相似文献
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目的观察医护一体化管理模式对沙库巴曲缬沙坦治疗老年心力衰竭患者用药依从性及并发症的影响。 方法纳入2020年1月至12月江苏省人民医院心血管内科收治的老年心力衰竭患者106例,入院后给予强心、利尿等常规治疗,并在常规治疗的基础上加用沙库巴曲缬沙坦治疗。将106例患者按入院后管理方式的不同分为2组,对照组55例采用常规管理,医护一体化组51例采用医护一体化模式管理,患者出院后随访6个月。观察2组患者出院后总有效率、满意度、依从性和并发症发生率的差异。 结果出院后6个月随访可见,与对照组相比,医护一体化组患者并发症发生率显著降低(P<0.05),而总有效率、用药依从性和满意度均显著提高(P<0.05)。 结论对沙库巴曲缬沙坦治疗的老年心力衰竭患者而言,采用医护一体化管理模式可有效提高患者出院后的用药依从性,在提高总体疗效的同时还降低了并发症发生率。 相似文献
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[摘要] 目的:观察常规抗心衰药物基础上换用沙库巴曲缬沙坦钠(Sacubitril/Valsartan,LCZ696)对慢性心力衰竭合并肾功能不全患者的临床疗效。方法:回顾性分析2018年9月至2020年9月在复旦大学附属闵行医院心内科治疗的射血分数降低型心力衰竭(HFrEF)合并肾功能不全患者196例,所有患者均接受指南导向药物治疗(GDMT),患者在抗心衰标准药物治疗基础上将ACEI/ARB替换为LCZ696治疗,平均观察(9.3±3.6)个月。比较患者治疗前后纽约心功能分级(NYHA),生活质量评分的变化,左心室射血分数(LVEF)、左心室舒张末内径(LVEDD)、血浆N-端脑钠肽前体(NT-proBNP)水平、eGFR及血钾的变化。结果:治疗后LVEF较治疗前显著升高,LVEDD较治疗前明显降低(P<0.001),NYHA分级明显改善(P<0.001); NT-ProBNP较治疗前明显降低(P<0.001)。治疗后躯体、情绪、其他领域及总分均较治疗前明显降低(P<0.05)。诊室日间收缩压和家庭自测夜间收缩压与治疗前相比均显著降低(P<0.05;P<0.01),eGFR较治疗前明显升高(P<0.01),血钾无明显变化(P>0.05)。结论:HFrEF合并肾功能不全患者在标准抗心衰药物治疗基础上换用LCZ696能明显改善NYHA分级、肾功能和生活质量评分,降低NT-ProBNP,对血钾无明显影响。符合适应症的慢性心衰合并肾功能不全患者应用沙库巴曲缬沙坦钠安全有效。 相似文献
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目的探讨糖尿病足溃疡(DFU)患者中性粒细胞淋巴细胞比值(NLR)与其病变严重程度的相关性及对预后的预测价值。方法回顾性分析2016年6月—2020年6月收治的DFU 176例的临床资料。收集入院时NLR、C反应蛋白(CRP)等指标,分析不同DFU病情、下肢缺血及感染程度NLR水平。根据随访6个月时转归分为预后良好组和预后不良组,应用多因素Logistic回归分析DFU患者预后不良的危险因素,并采用受试者工作特征(ROC)曲线评估NLR对DFU患者预后不良的预测价值。结果随病情严重程度、下肢缺血程度、感染程度加重NLR水平逐渐升高(P<0.01)。176例随访6个月后溃疡预后不良60例(34.09%)。NLR>6.58、CRP>58.35 mg/L是DFU患者预后不良的危险因素。NLR以7.17为临界值预测DFU患者预后不良的曲线下面积高于CRP(P<0.01)。结论DFU患者短期预后不良风险高,NLR能反映其病变程度,且早期预测预后不良的价值高于CRP。 相似文献
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Since their inception in the 1960s–70s, mesenchymal stem/stromal cells (MSCs) have gained interest because of their differentiation potential, anti-inflammatory effects, and immune-modulating properties. Both cell-based and cell-free MSC treatments show healing capacity in injured tissues. Cell-based treatment comprises MSCs and all secreted products, whereas cell-free treatments include only the secreted products. MSCs are therapeutically administered to many damaged organs owing to their efficacy. Specifically, the eye is a unique organ system to study the effects of MSCs, as treatment is easily applied and measured owing to its external location. The eye holds an immune-privileged status, wherein inflammation and immune responses are innately down-regulated. As excessive inflammation in the cornea often leads to fibrosis and irreversible corneal hazing, many studies have investigated the anti-inflammatory and immune-modulating capacities of MSCs. Decades of research suggest that MSCs modulate the immune response by secreting cytokines, growth factors, and extracellular matrix proteins that inhibit the infiltration of inflammatory cells following injury and promote a healing phenotype via M2 macrophage polarization. MSCs have also shown trans-differentiation potential into cornea-specific cell types during the wound healing process, such as corneal epithelial, stromal, or endothelial cells. This review discusses recent investigations of MSC treatment in the cornea, focusing on therapeutic efficacy, mechanisms, and future directions. 相似文献
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