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1.
Subconjunctival bevacizumab for corneal neovascularization   总被引:2,自引:0,他引:2  
Objective To report the efficacy of subconjunctival bevacizumab injection in patients with corneal neovascularization (NV). Methods This retrospective interventional case study included two eyes of two patients with corneal NV due to aqueous-deficient dry eye with filamentary keratitis in the first case, and corneal graft failure in the second case. Patients received a subconjunctival injection of 2.5 mg (0.1 ml) bevacizumab. Morphologic changes were investigated by slit-lamp biomicroscopy and corneal photography. Results Corneal NV was dramatically regressed a week after injection in the first case. In the second case, minor vessels were regressed while the major one did not. No infection or inflammation was observed. No relapse was seen within the follow-up of two to three months. Conclusion Subconjunctival injection of bevacizumab may offer an additional strategy for the treatment of corneal NV.  相似文献
2.
高度近视伴色觉缺失的家系分析   总被引:2,自引:0,他引:2  
目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能.结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变.2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传.结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础.  相似文献
3.
Background To evaluate the results of pars plana vitrectomy with peeling of the internal limiting membrane (ILM) in eyes with chronic macular oedema.Methods PPV with indocyanine green (ICG) assisted peeling of the ILM was performed in 33 eyes with diabetic (21 eyes) or non-diabetic (12 eyes) macular oedema. Postoperatively, resolution of macular oedema, improvement of visual acuity (VA) and complications were documented. The peeled membranes were submitted for light and transmission electron microscopic evaluation.Results The mean follow-up time was 12.2 months. The macular oedema decreased or was resolved in 17 (81%) eyes in the diabetic group and in 11 (92%) eyes in the non-diabetic group. VA improved by at least 2 lines in 11 (52%) eyes in the diabetic group and in 7 (58%) eyes in the non-diabetic group. The difference between visual acuity improvements of the two groups was not statistically significant (P>0.05). However, in the diabetic group the difference of visual improvement between cystoid and diffuse type of macular oedema eyes was statistically significant (14% versus 71%, P=0.02). Light and transmission electron microscopy showed the presence of ILM in all specimens. During the follow-up period no recurrence of macular oedema or epiretinal membrane formation was observed.Conclusion Pars plana vitrectomy with peeling of the ILM and epiretinal membrane leads to the resolution of macular oedema in the majority of eyes. This however, is not always associated with VA improvement. In diabetic eyes, cystoid type of macular oedema appears to be a poor prognostic factor for improved VA.  相似文献
4.
Eosinophilic angiocentric fibrosis of the orbit   总被引:1,自引:0,他引:1  
A 30-year-old woman complained of right-sided epiphora for 2 years. She also reported diplopia on certain gaze positions and felt a hard mass behind the right medial inferior orbital rim. Magnetic resonance imaging studies demonstrated a relatively well-delineated mass in the right inferomedial orbit with minimal ethmoid sinus involvement. Histopathological evaluation following a large incisional biopsy showed massive eosinophilic infiltration and fibrosis with the final diagnosis of eosinophilic angiocentric fibrosis. She was then discovered to have significant peripheral eosinophilia and elevated serum IgE levels and clinical findings of allergic rhinitis and sinusitis. She was treated with systemic fluorocortolon and desloratadin for 4 months. She remained stable without recurrence for 32 months. The patient with this exceptionally rare tumour of the orbit benefited from debulking surgery followed by systemic corticosteroids and antihistaminics.  相似文献
5.
Microbial keratitis in West Anatolia,Turkey: a retrospective review   总被引:1,自引:0,他引:1  
Purpose To analyze the clinical and microbiological characteristics of microbial keratitis in West Anatolia, Turkey during a 16-year period. Methods This is a retrospective study in which medical records were reviewed for all eyes with clinically diagnosed microbial keratitis presenting at the Izmir Ataturk Training and Research Hospital from January 1990 to December 2005. Risk factors, microbial isolations and clinical features were analyzed. Results Microbial keratitis was diagnosed for 620 eyes in 620 patients (250 women and 370 men; mean age: 54.13 years ± 20.06). Pathogens from cultures were identified for 225 eyes (36.2%) and included Gram-negative (8.9%) and Gram-positive micro-organisms (68.8%) and fungi (22.3%). Staphylococcus epidermidis was the most commonly isolated micro-organism (26.6%), followed by S. aureus (24.4%), Streptococci pneumoniae (15.5%), fungi (22.3%), Pseudomonas species (6.6%), Enterobacter (2.2%) and Corynebacterium (2.2%). Ocular trauma was the most common predisposing factor (26.6%). Mean duration from onset of symptoms to diagnosis was 11.68 ± 11.29 days. Conclusion Staphylococci are the most commonly isolated microbial agents in cases of infectious keratitis in West Anatolia, Turkey. These findings will provide valuable background information and facilitate successful treatment in this region, and they will be useful as reference data for the particular population in this region as a basis for empirical antibiotic therapy.  相似文献
6.
同一家庭3个姐妹色觉障碍   总被引:1,自引:0,他引:1  
目的:评价我校医学生和她的家庭成员先天色觉障碍的遗传特征,以建立其遗传模式.方法:运用Ishihara(石原)假同色图试验测定色觉障碍,用FW100色调试验评估其类型.并进行眼科检查和遗传学研究,建立色盲家谱,并对她的家庭给予遗传学咨询.结果:眼科检测结果显示双眼最佳矫正视力为20/20(1.0),近视矫正屈光度-2D,裂隙灯检测和眼压测量结果在正常范围,眼底镜检查视神经、黄斑和周边视网膜均正常,其它外眼评估和神经学检测正常,先证者的姐妹和她父母的眼科检测也正常,3姐妹和父亲的IPPT试验错误得分为19~20/25,结果和红绿色盲中绿色觉异常者一致.染色体分析和卵巢周期均正常.结论:根据她家谱,她的色盲是伴X染色体的隐性外显率模式的遗传特征.  相似文献
7.
Between 1973 and 1987 we recorded 300 cases of Behçet's disease with fundus changes. Our routine preview of each case included examination with the Goldman three-mirror contact lens, ophthalmoscopy, referral for laboratory tests, color fundus photography and, most importantly, fluorescein angiography. The ophthalmological findings led to the proper diagnosis in 254 (85%) of our cases. Fluorescein angiography revealed incipient fundus changes in 38 eyes of 19 medically diagnosed patients with no visual complaints and normal fundi on ophthalmoscopy. Eighty-six percent of our cases had or developed diverse fundus changes bilaterally. The fundus changes we encountered most frequently were hyperemia of the optic disc, macula edema, retinal edema, vascular sheathing, retinal exudate, and retinal hemorrhage. With the exception of eyes with very poor prognoses, only 184 of the 403 eyes that were followed up for 3–120 months (median 12) experienced new insults in the posterior segment; 40 of these became totally blind while 59 maintained their visual status. Early diagnosis is necessary for proper treatment patients with Behçet's disease. Fluorescein angiography is required for early diagnosis and for monitoring the posterior segment involvement closely. This is the most characteristic and often the most serious consequence of Behçet's disease; it may also the first indicator of the disease.Presented at the XVIth Meeting of the Club Jules Gonin, Bruges, 4–8 September 1988  相似文献
8.
In this experimental study, various foreign bodies were inserted into fresh bovine eyes, in different localizations. Twenty-one magnetic and non-magnetic foreign bodies, dimensions of which varied from 1.5 × 1.5 × 2 mm to 3.5 × 6 × 7 mm, were tried to detect by computed tomography (CT) and magnetic resonance imaging (MRI) scanning. In addition, further dissections were applied to check the ocular damage attributable to movement of the foreign bodies. Ferromagnetic foreign bodies have been shown to move in the eye and the risk of torsional forces being applied to the ferromagnetic foreign body seemed to cause intraocular complications during MRI scanning. All of the foreign bodies that were implanted in bovine eyes were recognized on CT scanning, except intraocular lenses. As a general rule, metallic foreign bodies produced beamhardening artifacts, but these artifacts did not cause any problem in detecting the localizations of foreign bodies.  相似文献
9.
Topical application of acetazolamide has no known effect on intraocular pressure (IOP). We tried to detect the hypotensive effect on IOP of acetazolamide soaked onto soft contact lenses (CL). We applied CLs soaked in either 1%, 3%, or 5% acetazolamide solution onto one eye of 29 rabbits while the contralateral eye served as a control. There was an average 32% reduction of IOP amongst all acetazolamide applied eyes, and an average 19% reduction of IOP amongst all control eyes. Amongst the 1% acetazolamide-CL applied eyes there was a mean 37% reduction of IOP, amongst the 3% acetazolamide-CL applied eyes a mean 36% reduction, amongst the 5% acetazolamide-CL applied a mean 30% reduction, and a mean 19% reduction in control eyes. The longest period of IOP reduction followed the application of 1% acetazolamide-CLs, probably owing to improved drug corneal penetration at this concentration. Our results reveal that the application of acetazolamide soaked soft CLs has a significant hypotensive effect on IOP in both the applied and contralateral control eyes of rabbits.  相似文献
10.
The aim of this study is to determine the effects of posterior chamber implantation on angle structures. First, without previous knowledge of the position of lens haptics, 360° gonioscopy was performed and any changes in the angle structures were recorded. Then, the pupil was dilated to determine the exact position of the intraocular lens haptics. The apposition of peripheral iris to angle structures or, at least, the narrowing of the angle corresponding to the lens haptic position was observed in almost all of the 117 examined eyes, with no difference found between bag and sulcus implantation. Peripheral anterior synechia overlying the lens haptic was observed in 49 (41.8%) of 117 eyes. Interestingly, we also noted that there was marked and well-limited clumping of pigment in the angle at 6 o'clock position in 67 (57.2%) of 117 eyes. In conclusion, we feel that posterior chamber intraocular lenses are not completely innocuous to the angle structures.  相似文献
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