TightRope?

Surgical treatment of horizontally or vertically unstable acromioclavicular (AC) joint dislocations covers a wide range of surgical techniques, e.g. stabilization via a tension band, hooked tie plate or Bosworth screw. Many of these techniques are often accompanied by various complications so that a stabilizing, low complication and approximately physiological surgical treatment has moved increasingly into the focus of scientific interest. Through further development of the dynamic TightRope? system in syndesmosis surgery there is now the possibility to treat unstable AC joint dislocations in a similar manner. Advantages include improved cosmetic aspects through a less stressful surgical access as well as the reduction of postoperative infections and the fact that a second intervention to remove the metal implants is no longer necessary. Within the framework of biomechanical studies scientists were able to show that the TightRope? treatment was able to create a stable situation and to provide a sufficient load capacity.     

Mitigation of septic shock in mice and rhesus monkeys by human chorionic gonadotrophin-related oligopeptides

The marked improvement of several immune‐mediated inflammatory diseases during pregnancy has drawn attention to pregnancy hormones as potential therapeutics for such disorders. Low molecular weight fractions derived from the pregnancy hormone human chorionic gonadotrophin (hCG) have remarkable potent immunosuppressive effects in mouse models of diabetes and septic shock. Based on these data we have designed a set of oligopeptides related to the primary structure of hCG and tested these in models of septic shock in mice and rhesus monkeys. We demonstrate that mice exposed to lipopolysaccharide (LPS) and treated subsequently with selected tri‐, tetra‐, penta‐ and hepta‐meric oligopeptides (i.e. MTR, VVC, MTRV, LQGV, AQGV, VLPALP, VLPALPQ) are protected against fatal LPS‐induced septic shock. Moreover, administration of a cocktail of three selected oligopeptides (LQGV, AQGV and VLPALP) improved the pathological features markedly and nearly improved haemodynamic parameters associated with intravenous Escherichia coli‐induced septic shock in rhesus monkeys. These data indicate that the designed hCG‐related oligopeptides may present a potential treatment for the initial hyperdynamic phase of septic shock in humans.