化学试剂行业钼盐产品作业工人职业性眼病的研究

本文对化学试剂厂从事钼盐产品专业厂的１０５名职工详细询问了病史，并进行了眼科全面检查。受检者分为接触组８３人和对照组２２人。接触毒物主要为钼盐类。检查结果表明２组受检者在眼部症状、眼病史、外眼病发生率、角膜知觉、调节近点、辐辏近点诸方面有显著性差异。角膜染色２组间无显著性，但２组与正常人群比较均有显著性，说明钼盐类化学物质对作业工人眼部有一定的影响。本文并提出相应的防护措施。     

聚环氧乙烷/LixMoO3纳米复合材料的制备及表征

介绍了聚环氧乙烷（ＰＥＯ）／ＬｉｍＭｏＯ３纳米复合材料的制备过程。结果表明,ＰＥＯ大分子插入到ＬｉｘＭｏＯ３片层间,使层间距增大了０．７３ｎｍ。ＰＥＯ在ＬｉｘＭｏＯ３层间呈ＰＥＯ－ＨｇＣｌⅠ型构象,其运动能力受到限制。     

乳腺癌的CT和钼靶摄影分析

目的 探讨CT和钼靶摄影在诊断乳腺癌中的价值。方法 收集23例乳腺癌，均为术后病理证实。钼靶采用美国GE公司Senographe2000D全数字化乳腺X线摄影机进行头尾位和中侧斜位进行双乳摄影，必要时加照中侧位和局部点压放大及其他特殊体位摄影。CT采用snmalom AR．SP螺旋CT机进行平扫和增强扫描，扫描范围从腋窝顶部至乳房下界。23例全部采用增强扫描，分别在注射造影剂100ml后30s、60s、90s时进行动脉相、静脉相、延迟相哪扫描，病人采用俯卧位，上胸及腹部垫高，使乳房自然下垂，双前臂交叉放在头上。结果 钼靶对乳腺癌诊断率为78．3％，钼靶和CT结合达到91．3％。在显示病变与周围组织的关系、腋窝淋巴结、观察病变的血流动力学改变及小而致密的乳腺或贴近胸壁的病变，CT优于钼靶。对微小钙化的显示，钼靶比CT敏感。结论 临床可疑乳腺癌病例先进行钼靶摄影，必要时进行叫增强扫描，二者结合可明显提高诊断率。     

钼靶联合hMAM、BRCA-1表达水平检测对乳腺癌的诊断价值

目的探讨钼靶联合乳腺癌人乳腺珠蛋白(hMAM)基因、乳腺癌易感基因-1(BRCA-1)表达水平对乳腺癌的诊断价值。方法选取2016年1月至2019年8月在该院就诊的乳腺癌患者150例纳入肿瘤组,另选取同期良性乳腺肿瘤患者100例纳入良性组。通过受试者工作特征(ROC)曲线分析单独及联合应用钼靶及hMAM、BRCA-1检测诊断乳腺癌的灵敏度、特异度、ROC曲线下面积(AUC)等。结果肿瘤组钼靶检测阳性率(68.7%)明显高于良性组(27.0%),差异有统计学意义(χ2=41.730,P<0.05)。肿瘤组hMAM表达水平明显高于良性组,BRCA-1表达水平明显低于良性组,差异有统计学意义(t=49.723、30.632,P<0.05)。钼靶及hMAM、BRCA-1联合检测诊断乳腺癌的灵敏度(78.7%)明显高于单独检测的灵敏度(68.7%、57.3%、60.7%),差异有统计学意义(P<0.05),还保持了较高的特异度(79.0%),联合检测的AUC(0.864)明显高于单独检测(0.792、0.753、0.642),差异有统计学意义(P<0.05)。结论钼靶检测及hMAM、BRCA-1表达水平检测可提高乳腺癌诊断的灵敏度,并保持较高的特异度,对乳腺癌诊断有重要的临床价值。     

Effects of Deposition and Annealing Temperature on the Structure and Optical Band Gap of MoS2 Films

In this study, molybdenum disulfide (MoS₂) film samples were prepared at different temperatures and annealed through magnetron sputtering technology. The surface morphology, crystal structure, bonding structure, and optical properties of the samples were characterized and analyzed. The surface of the MoS₂ films prepared by radio frequency magnetron sputtering is tightly coupled and well crystallized, the density of the films decreases, and their voids and grain size increase with the increase in deposition temperature. The higher the deposition temperature is, the more stable the MoS₂ films deposited will be, and the 200 °C deposition temperature is an inflection point of the film stability. Annealing temperature affects the structure of the films, which is mainly related to sulfur and the growth mechanism of the films. Further research shows that the optical band gaps of the films deposited at different temperatures range from 0.92 eV to 1.15 eV, showing semiconductor bandgap characteristics. The optical band gap of the films deposited at 200 °C is slightly reduced after annealing in the range of 0.71–0.91 eV. After annealing, the optical band gap of the films decreases because of the two exciton peaks generated by the K point in the Brillouin zone of MoS₂. The blue shift of the K point in the Brillouin zone causes a certain change in the optical band gap of the films.     

An In Situ Reflectance Spectroscopic Investigation to Monitor Two-Dimensional MoS2 Flakes on a Sapphire Substrate

In this work, we demonstrate the application of differential reflectance spectroscopy (DRS) to monitor the growth of molybdenum disulfide (MoS₂) using chemical vapor deposition (CVD). The growth process, optical properties, and structure evolution of MoS₂ were recorded by in-situ DRS. Indeed, blue shifts of the characteristic peak B were discussed with the decrease of temperature. We also obtained the imaginary part of the MoS₂ dielectric constant according to reflectance spectra. This method provides an approach for studying the change of two-dimensional (2D) materials’ dielectric constant with temperature. More importantly, our work emphasizes that the DRS technique is a non-destructive and effective method for in-situ monitoring the growth of 2D materials, which is helpful in guiding the preparation of 2D materials.     

Cellular proliferation and differentiation induced by single-layer molybdenum disulfide and mediation mechanisms of proteins via the Akt-mTOR-p70S6K signaling pathway

Single-layer molybdenum disulfide (SLMoS₂) is a novel kind of 2D nanosheet that has attracted great attention regarding its use in biosensors, drug delivery, tissue engineering, and therapy. However, our results demonstrated that SLMoS₂ accelerated proliferation and promoted myogenic differentiation and epithelial–mesenchymal transition (EMT) in human embryonic lung fibroblasts (HELFs). The abnormal proliferation and differentiation of HELFs contribute to idiopathic pulmonary fibrosis. Specifically, SLMoS₂ significantly stimulated the expression of myofibroblast- and mesenchymal-associated genes and proteins. The Akt-mTOR-p70S6K signaling pathway plays a critical role in the acceleration of proliferation and promotion of myogenic differentiation and EMT in HELFs induced by SLMoS₂. After cell uptake, SLMoS₂ was primarily located in the cytoplasm and the perinuclear region and activated Akt-dependent signaling due to the generation of reactive oxygen species (ROS). Moreover, bovine serum albumin (BSA) binding markedly inhibited the cellular uptake of SLMoS₂ and the production of intracellular ROS due to an increased thickness and reduced adhesion of HELFs. BSA binding also mitigated the SLMoS₂-activated phosphorylation of Akt-dependent signaling pathways. This study is the first to illustrate the induction of cellular proliferation and differentiation by SLMoS₂ and the related mediation by proteins through Akt-mTOR-p70S6K signaling pathway.     

Quantitative in vivo biocompatibility of new ultralow‐nickel cobalt–chromium–molybdenum alloys

Nickel (Ni) eluted from metallic biomaterials is widely accepted as a major cause of allergies and inflammation. To improve the safety of cobalt–chromium–molybdenum (Co–Cr–Mo) alloy implants, new ultralow‐Ni Co–Cr–Mo alloys with and without zirconium (Zr) have been developed, with Ni contents of less than 0.01%. In the present study, we investigated the biocompatibility of these new alloys in vivo by subcutaneously implanting pure Ni, conventional Co–Cr–Mo, ultralow‐Ni Co–Cr–Mo, and ultralow‐Ni Co–Cr–Mo with Zr wires into the dorsal sides of mice. After 3 and 7 days, tissues around the wire were excised, and inflammation; the expression of IL‐1β, IL‐6, and TNF‐α; and Ni, Co, Cr, and Mo ion release were analyzed using histological analyses, qRT‐PCR, and inductively coupled plasma mass spectrometry (ICP‐MS), respectively. Significantly larger amounts of Ni eluted from pure Ni wires than from the other wires, and the degree of inflammation depended on the amount of eluted Ni. Although no significant differences in inflammatory reactions were identified among new alloys and conventional Co–Cr–Mo alloys in histological and qRT‐PCR analyses, ICP‐MS analysis revealed that Ni ion elution from ultralow‐Ni Co–Cr–Mo alloys with and without Zr was significantly lower than from conventional Co–Cr–Mo alloys. Our study, suggests that the present ultralow‐Ni Co–Cr–Mo alloys with and without Zr have greater safety and utility than conventional Co–Cr–Mo alloys. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1505–1513, 2016.     

乳腺疾病超声与钼靶 X线诊断回顾性分析

目的：探讨超声、钼靶X线在乳腺疾病中的诊断价值。方法回顾性分析102例患者超声及钼靶影像资料,并且以临床病理结果作为对照标准。结果乳腺疾病超声诊断符合率87．3％,X线钼靶诊断符合率84．3％,两者联合应用诊断符合率92．2％。结论超声与钼靶对乳腺疾病诊断均有较大价值,乳腺超声可作为乳腺疾病普查首选方法,两者联合应用可提高乳腺疾病诊断符合率。     

Cysteine-Induced Hybridization of 2D Molybdenum Disulfide Films for Efficient and Stable Hydrogen Evolution Reaction

The noble, metal-free materials capable of efficiently catalyzing water splitting reactions currently hold a great deal of promise. In this study, we reported the structure and electrochemical performance of new MoS₂-based material synthesized with L-cysteine. For this, a facile one-pot hydrothermal process was developed and an array of densely packed nanoplatelet-shaped hybrid species directly on a conductive substrate were obtained. The crucial role of L-cysteine was determined by numerous methods on the structure and composition of the synthesized material and its activity and stability for hydrogen evolution reaction (HER) from the acidic water. A low Tafel slope of 32.6 mV dec⁻¹, close to a Pt cathode, was registered for the first time. The unique HER performance at the surface of this hybrid material in comparison with recently reported MoS₂-based electrocatalysts was attributed to the formation of more defective 1T, 2H-MoS₂/MoO_x, C nanostructures with the dominant 1T-MoS₂ phase and thermally degraded cysteine residues entrapped. Numerous stacks of metallic (1T-MoS₂ and MoO₂) and semiconducting (2H-MoS₂ and MoO₃) fragments relayed the formation of highly active layered nanosheets possessing a low hydrogen adsorption free energy and much greater durability, whereas intercalated cysteine fragments had a low Tafel slope of the HER reaction. X-ray photoelectron spectroscopy, scanning electron microscopy, thermography with mass spectrometry, high-resolution transmission electron microscopy, Raman spectroscopy techniques, and linear sweep voltammetry were applied to verify our findings.