Enhanced zinc consumption causes memory deficits and increased brain levels of zinc

Zinc deficiency has been shown to impair cognitive functioning, but little work has been done on the effects of elevated zinc. This research examined the effect on memory of raising Sprague-Dawley rats on enhanced levels of zinc (10 ppm ZnCO3; 0.153 mM) in the drinking water for periods of 3 or 9 months, both pre- and postnatally. Controls were raised on lab water. Memory was tested in a series of Morris Water Maze (MWM) experiments, and zinc-treated rats were found to have impairments in both reference and working memory. They were significantly slower to find a stationary platform and showed greater thigmotaxicity, a measure of anxiety. On a working memory task, where the platform was moved each day, zinc-treated animals had longer latencies over both trials and days, swam further from the platform, and showed greater thigmotaxicity. On trials using an Atlantis platform, which remained in one place but was lowered on probe trials, the zinc-treated animals had significantly fewer platform crossings, spent less time in the target quadrant, and did not swim as close to the platform position. They had significantly greater latency on nonprobe trials. Microprobe synchrotron X-ray fluorescence (microSXRF) confirmed that brain zinc levels were increased by adding ZnCO3 to the drinking water. These data show that long-term dietary administration of zinc can lead to impairments in cognitive function.     

An adjustable microplate platform

Summary An adjustable platform has been designed to facilitate the addition of biological assay components to a multiwell microplate. Nonmanifold additions of liquid components to microplate wells are made especially easy by using this device. The microplate platform can accommodate any of the common formats of disposable microplates. Moreover, it can be adjusted to varying angles allowing the investigator to view into all the wells as assay components are being added.     

科云生产管理平台在期刊集约化生产中的探索实践

【目的】 分享科云生产管理平台(以下简称“科云平台”)在数据中台建设以及出版生产管理方面的实践与经验,为出版同行建设学术服务平台以及实现数字化出版流程管理提供参考。【方法】 分享科云平台架构,梳理科云平台在期刊集约化出版生产中的特色功能与作用,阐明科云平台对期刊集群化发展的促进作用,同时提出科云平台下一步设想。【结果】 基于科云平台,对出版流程进行切分、优化,细化编辑分工,有助于提升期刊质量和出版效率,并形成集约化出版模式;构建数据中台,将数据与业务相契合,形成闭环模式,有助于提升数字出版平台的学术服务能力。【结论】 坚持以技术革新为突破口,突破传统出版模式,搭建具有自主知识产权的数字化出版管理平台是实现科技期刊可持续发展的必由之路,有助于推动科技期刊数字化转型升级、加快科技期刊集群化发展。     

A Web-Based Interactive Patient-Provider Software Platform Does Not Increase Patient Satisfaction or Decrease Hospital Resource Utilization in Total Knee and Hip Arthroplasty Patients in a Single Large Hospital System

BackgroundWeb-based platforms used to enhance patient-provider communication are being explored to improve patient satisfaction and care delivery, and decrease cost. This study tested a web-based interactive patient-provider software platform (IPSP), JointCOACH, which enabled patient communication with their care team and preparatory/recovery guidance. The aims of this study are to compare (1) patient satisfaction and (2) healthcare resource utilization by patients who underwent total knee and hip replacements and added IPSP to standard of care (SOC).MethodsThis study is a prospective, randomized clinical trial at a single large academic healthcare system. Between May 2018 and March 2020, 399 patients undergoing elective total hip or knee arthroplasty were randomized to SOC arm (n = 204) or SOC + IPSP arm (n = 195). Patient demographics, surgical details, and comorbidities were collected. Patient satisfaction was assessed using Visual Analog Scale and the Picker Patient Experience-15. Healthcare utilization was measured using length of stay, emergency department and office visits, office calls, readmissions, and reoperations at 30 and 90 days after surgery.ResultsNo difference was found in length of stay between SOC and SOC + IPSP. No differences were found in 30-day or 90-day satisfaction or in healthcare resource utilization (P > .05) including number of office and emergency department visits, phone calls, and readmissions.ConclusionStatistical differences were not found in satisfaction and healthcare utilization with the addition of IPSP to SOC. IPSP can be used to reinforce patient education and communication between the patient and provider, and should be evaluated as an element of virtual care rather than supplementing traditional in-office follow-up.Clinicaltrials.govMore information on this study can be found at clinicaltrials.gov NCT03499028.     

基于点云数据的髋臼置钉通道全局优化

针对髋臼前后柱置钉通道多截面调控规划法的不足,该研究提出了基于大密度点云数据、相关理论、软件内置功能及自编程序的规划方法,实现了对置钉通道总长的全局优化,同时进行了基于7截面、11截面调控规划法以及点云数据的前柱最大内接圆柱体虚拟置钉实验,分析了实验结果及形成机理,验证了基于点云数据规划法的全局优化效果,但对多截面调控规划法的调控有效性表示还存有疑问,此外,还对基于点云数据的髋臼置钉通道规划方法应用的相关原理和操作技巧作了简略介绍。     

病案终末监控的新模式

目的探讨病案终末监控的新模式对病案质量的影响。方法每月抽查每位医师2～3份出院病案,结果汇总后反馈给经治医师进行自监,自监结果交回病案室计分。对分数有疑义者请多名专家复议,然后计分。最终得出病案质量和监控能力分数。结果病案质量得到了全面、客观、准确的监控,全员重视病案质量的意识也明显提高,甲级病案率达98．2％。结论病案终末监控的新模式对病案质量和监控能力的提高有很大影响。     

浅谈医院客户服务电子平台的建设

目的通过信息化管理手段,提高医院客户服务中心管理水平。方法采用计算机、网站、电话、短信、视频等多种技术,建立一体化的客户服务电子平台。结果实现市场调研、分析、宣传和客户服务系统化管理。结论解决了客户管理分散和人工操作的现状,提高了工作效率,增进了人性化服务,加强了客户档案管理。     

网上医用耗材采购解决方案

通过介绍医用耗材招标及中标医用耗材配送监管整个过程中信息技术的运用，提出了一套简单、实用的解决方案。     

基于新型冠状病毒肺炎的临床数据治理和科研平台建设实践

我院作为新型冠状病毒肺炎患者收治的定点医院,积累了大量新型冠状病毒肺炎患者的医疗数据.为有效利用这些数据为临床关于新型冠状病毒肺炎科研攻关服务,我院自主研发基于新型冠状病毒肺炎的科研数据平台.利用ETL工具KETTLE整合新型冠状病毒肺炎患者的门诊和住院数据,跨平台采集和清洗HIS、电子病历、LIS和PACS等业务系统...     

基于智能化平台的医院配电系统安全探讨

结合实例,对医院建设配电安全平台的需求进行分析,阐述了配电安全平台的开发思路及系统功能,总结出应用配电智能化系统的成效.