全文获取类型
收费全文 | 1285篇 |
免费 | 69篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 10篇 |
妇产科学 | 8篇 |
基础医学 | 47篇 |
口腔科学 | 6篇 |
临床医学 | 83篇 |
内科学 | 78篇 |
皮肤病学 | 9篇 |
神经病学 | 27篇 |
特种医学 | 23篇 |
外科学 | 62篇 |
综合类 | 548篇 |
预防医学 | 226篇 |
眼科学 | 1篇 |
药学 | 139篇 |
7篇 | |
中国医学 | 45篇 |
肿瘤学 | 33篇 |
出版年
2023年 | 20篇 |
2022年 | 73篇 |
2021年 | 100篇 |
2020年 | 90篇 |
2019年 | 35篇 |
2018年 | 58篇 |
2017年 | 85篇 |
2016年 | 102篇 |
2015年 | 67篇 |
2014年 | 138篇 |
2013年 | 95篇 |
2012年 | 74篇 |
2011年 | 80篇 |
2010年 | 46篇 |
2009年 | 41篇 |
2008年 | 47篇 |
2007年 | 28篇 |
2006年 | 37篇 |
2005年 | 19篇 |
2004年 | 19篇 |
2003年 | 16篇 |
2002年 | 24篇 |
2001年 | 7篇 |
2000年 | 8篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 8篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1973年 | 1篇 |
1972年 | 2篇 |
排序方式: 共有1361条查询结果,搜索用时 31 毫秒
1.
《Vaccine》2022,40(30):3999-4007
BackgroundA value of vaccination framework for economic evaluation (EE) identified unique value concepts for the broad benefits vaccination provides to individuals, society, healthcare systems and national economies. The objectives of this paper were to work with experts in developed countries to objectively identify three priority concepts to extend current EE.MethodsThe previously developed classification of value concepts in vaccination distinguished 18 concepts, categorised as conventional payer and societal perspective concepts and novel broader societal concepts. Their inclusion in current EE guidelines was assessed. Experts identified eight criteria relevant to decision-making and measurement feasibility, which were weighted and used to score each concept. The relative ranking of concepts by importance and the gaps in guidelines were used to identify three priority concepts on which to focus immediate efforts to extend EE.ResultsThe EE guidelines review highlighted differences across countries and between guidelines and practice. Conventional payer perspective concepts (e.g., individual and societal health gains and medical costs) were generally included, while gaps were evident for conventional societal perspective concepts (e.g., family/caregiver health and economic gains). Few novel broader societal benefits were considered, and only in ad hoc cases. The top-three concepts for near-term consideration: macroeconomic gains (e.g., benefiting the economy, tourism), social equity and ethics (e.g., equal distribution of health outcomes, reduced health/financial equity gaps) and health systems strengthening, resilience and security (e.g., efficiency gains, reduced disruption, increased capacity).ConclusionsGaps, inconsistencies and limited assessment of vaccination value in EE can lead to differences in policy and vaccination access. The three priority concepts identified provide a feasible approach for capturing VoV more broadly in the near-term. Robust methods for measuring and valuing these concepts in future assessments will help strengthen the evidence used to inform decisions, improving access to vaccines that are demonstrably good value for money from society’s point of view. 相似文献
2.
3.
《Clinical neurophysiology》2021,132(8):1820-1829
Objective: to obtain locally valid reference values (RVs) from existing nerve conduction study (NCS) data.Methods: we used age, sex, height and limb temperature-based mixture model clustering (MMC) to identify normal and abnormal measurements on NCS data from two university hospitals. We compared MMC-derived RVs to published data; examined the effect of using different variables; validated MMC-derived RVs using independent data from 26 healthy control subjects and investigated their clinical applicability for the diagnosis of polyneuropathy.Results: MMC-derived RVs were similar to published RVs. Clustering can be achieved using only sex and age as variables. MMC is likely to yield reliable results with fewer abnormal than normal measurements and when the total number of measurements is at least 300. Measurements from healthy controls fell within the 95% MMC-derived prediction interval in 97.4% of cases.Conclusions: MMC can be used to obtain RVs from existing data, providing a locally valid, accurate reflection of the (ab)normality of an NCS result.Significance: MMC can be used to generate locally valid RVs for any test for which sufficient data are available.1 相似文献
4.
5.
The fatality risk–money tradeoff that is the value of a statistical life (VSL) may vary with the nature of the fatality event. While all fatalities involve loss of future life expectancy, the morbidity effects and their duration may differ. This article analyzes fatality risks accompanied by morbidity effects of different duration to disentangle the mortality and morbidity components of VSL using data from the Census of Fatal Occupational Injuries (CFOI). The VSL is comprised of the sum of the value of the fatality risk and the value of the morbidity risk. Labor market valuations of morbidity risks are positive, even for fatalities that are caused by traumatic injuries. The value of the fatality risk is the dominant component of VSL, rather than the value of the morbidity risk. 相似文献
6.
7.
8.
目的:研究急性阑尾炎诊断中高频超声的应用价值。方法:2018年4月~2019年12月本院接诊的急性阑尾炎病患75例,予以低频和高频超声检查。结果:本组高频超声诊断的准确率比低频超声高,P<0.05。结论:于急性阑尾炎诊断中运用高频超声,可提高诊断准确率。 相似文献
9.
《Vaccine》2021,39(38):5368-5375
BackgroundAnaphylaxis is a rare, serious allergic reaction. Its identification in large healthcare databases can help better characterize this risk.ObjectiveTo create an ICD-10 anaphylaxis algorithm, estimate its positive predictive values (PPVs) in a post-vaccination risk window, and estimate vaccination-attributable anaphylaxis rates in the Medicare Fee For Service (FFS) population.MethodsAn anaphylaxis algorithm with core and extended portions was constructed analyzing ICD-10 anaphylaxis claims data in Medicare FFS from 2015 to 2017. Cases of post-vaccination anaphylaxis among Medicare FFS beneficiaries were then identified from October 1, 2015 to February 28, 2019 utilizing vaccine relevant anaphylaxis ICD-10 codes. Information from medical records was used to determine true anaphylaxis cases based on the Brighton Collaboration’s anaphylaxis case definition. PPVs were estimated for incident anaphylaxis and the subset of vaccine-attributable anaphylaxis within a 2-day post-vaccination risk window. Vaccine-attributable anaphylaxis rates in Medicare FFS were also estimated.ResultsThe study recorded 66,572,128 vaccinations among 21,685,119 unique Medicare FFS beneficiaries. The algorithm identified a total of 190 suspected anaphylaxis cases within the 2-day post-vaccination window; of these 117 (62%) satisfied the core algorithm, and 73 (38%) additional cases satisfied the extended algorithm. The core algorithm’s PPV was 66% (95% CI [56%, 76%]) for identifying incident anaphylaxis and 44% (95% CI [34%, 56%]) for vaccine-attributable anaphylaxis. The vaccine-attributable anaphylaxis incidence rate after any vaccination was 0.88 per million doses (95% CI [0.67, 1.16]).ConclusionThe ICD-10 claims algorithm for anaphylaxis allows the assessment of anaphylaxis risk in real-world data. The algorithm revealed vaccine-attributable anaphylaxis is rare among vaccinated Medicare FFS beneficiaries. 相似文献
10.
目的探讨新生儿缺氧缺血性脑病(HIE)超声(US)、磁共振成像(MRI)表现及诊断价值。方法选定本院2019年3月至2021年3月收诊的80例HIE患儿,按照程度不同分为轻度(28例)、中度(30例)、重度(22例),同期选择30例健康新生儿,均行MRI、US检查。观察MRI、US两种影像学检测方法的诊断结果,比较其脑梗死(CI)、白质软化(PVL)、旁矢状区脑损伤(PBI)、基底节丘脑损伤(BGTI)、选择性神经元损伤(SND)、脑水肿(CE)病理显示情况。并记录MRI的表观扩散系数(ADC)值,以及US的阻力指数(RI)、舒张期峰值血流速度(VD)、收缩期峰值血流速度(VS),分析其相关性。结果(1)MRI的轻度检出率较US高,差异有统计学意义(P<0.05);其中、重度检出率与US相比,差异无统计学意义(P>0.05)。(2)MRI的CI、PVL、BGTI、CE病理显示率与US相比,差异无统计学意义(P>0.05);MRI的PBI、SND病理显示率较US高,差异有统计学意义(P<0.05)。(3)健康体检者、HIE轻度患儿、HIE中度及重度患儿的的ADC值、VD、VS、RI,差异有统计学意义(P<0.05);经Kendall秩相关系数检验,HIE患儿的ADC值与RI、VS呈负相关性,差异有统计学意义(P<0.05)。结论横向对比中,US与MRI部分诊断存在关联性,可相互补充;纵向对比中,MRI的诊断效果整体优于US。 相似文献