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1.
目的 应用时空关联成像-M模式(STIC-M)评价正常胎儿右心室收缩功能。方法 对胎儿正常的150名孕妇进行STIC-M检测,测量胎儿三尖瓣半环平面收缩位移(f-TAPSE);应用体器官计算机辅助分析自动测量技术测量胎儿右心室舒张末期容积和收缩末期容积,计算右心室每搏输出量和射血分数(RVEF),分析胎儿f-TAPSE、孕周、RVEF之间的相关性。结果 f-TAPSE与孕周呈显著正相关(r=0.964,P<0.01),与RVEF之间无相关性(r=0.040,P=0.773);胎儿RVEF相对恒定,不随孕周增加而变化,与孕周之间无相关性(r=-0.231,P=0.310)。结论 STIC-M评价正常胎儿右心室收缩功能简单、重复性好,值得临床推广应用。  相似文献   
2.
ObjectiveTo determine whether glycemic derangements are more effectively controlled using software-guided insulin dosing compared with paper-based protocols.Patients and MethodsWe prospectively evaluated consecutive critically ill patients treated in a tertiary hospital surgical intensive care unit (ICU) between January 1 and June 30, 2008, and between January 1 and September 30, 2009. Paper-based protocol insulin dosing was evaluated as a baseline during the first period, followed by software-guided insulin dosing in the second period. We compared glycemic metrics related to hyperglycemia, hypoglycemia, and glycemic variability during the 2 periods.ResultsWe treated 110 patients by the paper-based protocol and 87 by the software-guided protocol during the before and after periods, respectively. The mean ICU admission blood glucose (BG) level was higher in patients receiving software-guided intensive insulin than for those receiving paper-based intensive insulin (181 vs 156 mg/dL; P=.003, mean of the per-patient mean). Patients treated with software-guided intensive insulin had lower mean BG levels (117 vs 135 mg/dL; P=.0008), sustained greater time in the desired BG target range (95-135 mg/dL; 68% vs 52%; P=.0001), had less frequent hypoglycemia (percentage of time BG level was <70 mg/dL: 0.51% vs 1.44%; P=.04), and showed decreased glycemic variability (BG level per-patient standard deviation from the mean: ±29 vs ±42 mg/dL; P=.01).ConclusionSurgical ICU patients whose intensive insulin infusions were managed using the software-guided program achieved tighter glycemic control and fewer glycemic derangements than those managed with the paper-based insulin dosing regimen.  相似文献   
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A total of 76 unrelated male patients with mild (n = 55) or moderate (n = 21) haemophilia A living in the southern Brazilian state of Rio Grande do Sul were studied by direct sequencing of all F8 26 exons, the 5′ UTR and 3′ UTR, intron–exon junctions and the promoter region. When no mutation was found, a multiplex ligation‐dependent probe amplification analysis was performed. We identified the disease‐causing mutations in 69 patients, who showed 33 different mutations: 27 missense, one small deletion, two small duplications and three splice site mutations. Seven missense and two splice site mutations were not previously reported in HAMSTeRS and were not identified in any current literature search. Nine recurrent mutations were found, one of them never described before (p.Tyr1786Phe). Haplotype analysis indicated that this mutation had originated in the Brazilian population as a single event in a common ancestor. The possible influence of these mutations in the determination of the disease was carefully considered, including bioinformatic tools. These data add to the general knowledge of the disease and can also be useful for HA diagnosis and detection of carriers in the southern Brazilian population.  相似文献   
5.
随着三维及四维超声技术的迅速发展,时间-空间相关成像技术(STIC)已成为研究胎儿心脏的一种相对成熟的技术,其多种成像模式可提供更多结构及血流的相关信息,为临床诊断提供依据。STIC技术的反转模式可更清晰、准确地呈现心室腔和血管腔的立体结构。本文就其在胎儿心血管系统中的研究进展进行综述。  相似文献   
6.
目的 分析第三腰椎横突综合征患者的肌骨超声表现及与Oswestry功能障碍指数(ODI)的相关性。方法 回顾性分析2019年1月—2021年2月在河北省中医院就诊的121例第三腰椎横突综合征患者的临床资料(观察组),另取同期该院健康体检者50例作为对照组。治疗前后采用肌骨超声对患者进行检查;并采用ODI评价患者腰椎功能,分析肌骨超声表现与ODI评分的相关性。结果 治疗前,观察组肌骨超声评分、ODI评分高于对照组(P <0.05);治疗后观察组患者肌骨超声评分、ODI评分降低(P <0.05)。观察组治疗前后肌骨超声评分与ODI评分均呈正相关(r =0.735和0.681,P =0.009和0.018)。观察组治疗前后血清IL-6、IL-10、TNF-α水平均高于对照组(P <0.05);治疗后观察组血清IL-6、IL-10、TNF-α水平低于治疗前(P <0.05)。逐步多因素Logistic回归分析结果表明,肌骨超声评分[O^R=1.881(95% CI:1.239,2.856)]、ODI评分[O^R=1.848(95% CI:1.246,2.740)]、IL-6[O^R=1.818(95% CI:1.234,2.681)]、IL-10[O^R=1.868(95% CI:1.226,2.847)]、TNF-α[O^R=1.837(95% CI:1.224,2.756)]是影响第三腰椎横突综合征患者发病的独立危险因素(P <0.05)结论 第三腰椎横突综合征患者的肌骨超声表现与ODI评分呈正相关,肌骨超声评分、ODI评分、IL-6、IL-10、TNF-α是影响第三腰椎横突综合征患者发病的独立危险因素。  相似文献   
7.
BackgroundControl of tuberculosis (TB) depends on a balance between host's immune factors and bacterial evasion strategies. Interleukin-37 (IL-37) is among the immunomodulatory factors that have been proposed to influence susceptibility to tuberculosis.MethodsA case–control study was conducted on 105 patients with pulmonary TB (37 active, 41 multi-drug resistant and 27 relapse) and 79 healthy controls to determine serum levels and single nucleotide polymorphisms (SNPs) of IL-37. The IL-37 level was assessed with an enzyme-linked immunosorbent kit, while DNA-sequencing was used to detect SNPs in the promoter region of IL37 gene.Results: Median level of IL-37 was markedly increased in serum of TB patients compared to controls (325.0 vs. 169.1 pg/mL; p < 0.001). This increase was universally determined in subgroups of patients distributed according to gender, age groups, and clinical type of disease, while no significant differences were found between the subgroups in patients or controls. Analysis of receiver operating characteristic curve confirmed these findings and IL-37 occupied a very good area under the curve, which was 0.816 (95% CI = 0.744–0.888; p < 0.001). At a cut-off value of 185.6 pg/mL, the sensitivity and specificity of IL-37 were 81.0 and 82.3%, respectively. Of the nine detected SNPs (rs2466449 G/A, rs2466450 A/G, rs2723168 G/A, rs3811042 G/A, rs3811045 T/C, rs3811046 G/T, rs3811047 A/G, rs3811048 G/A and rs200782323 G/A), only rs3811048 showed a significant association with TB; the G allele showed a significantly decreased frequency in TB patients compared to controls (25.2 vs. 44.9%; OR = 0.41; p < 0.001). It was possible to assign five haplotypes, and three showed significant differences between patients and controls. Frequency of haplotype A-A-G-A-C-T-G-A-G (0.331 vs. 0.213; OR = 2.10; p = 0.015) was significantly increased in TB patients compared to controls. On the contrary, frequencies of haplotypes A-A-G-A-C-T-G-G-G (0.029 vs. 0.116; OR = 0.24; p = 0.01) and A-A-G-G-T-G-A-G-G (0.140 vs. 0.275; OR = 0.45; p = 0.015) were significantly decreased in patients.ConclusionsIL-37 was up-regulated in the serum of TB patients irrespective of their gender, age or clinical type of disease. SNPs in the promoter region of IL37 gene were proposed to be associated with susceptibility to TB.  相似文献   
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9.
目的 探索初诊前列腺癌(PCa)患者68镓标记的前列腺特异性膜抗原(68Ga-PSMA)-11 PET-CT的代谢体积参数与临床指标的相关性.方法 回顾性分析2019年1月至12月经前列腺活体组织穿刺病理学确诊,于海军军医大学(第二军医大学)长海医院行68Ga-PSMA-11 PET-CT检查的85例未经治疗PCa患者的影像学及临床资料.85例患者中未发生肿瘤转移的有46例(无转移组)、发生肿瘤转移的有39例(转移组).采用Spearman秩相关检验分别分析两组患者原发灶最大标准摄取值(SUVmax),原发灶平均标准摄取值(SUVmean)及病灶前列腺特异性膜抗原(PSMA)总量(TL-PSMA)等多个代谢体积参数与年龄、BMI、格里森评分(GS)、前列腺特异性抗原(PSA)等临床指标的相关性.结果 无转移组中,PSA与原发灶SUVmax、原发灶TL-PSMA呈中度正相关(rs=0.409,P=0.005;rs=0.587,P<0.001);而GS与原发灶SUVmax、原发灶TL-PSMA不相关(rs=0.181,P=0.229;rs=0.101,P=0.505).转移组中,PSA与原发灶TL-PSMA、转移灶TL-PSMA、全身病灶TL-PSMA呈中度正相关(rs=0.439,P=0.005;rs=0.588,P<0.001;rs=0.569,P<0.001),与原发灶SUVmax不相关(rs=0.255,P=0.117);而GS与原发灶SUVmax、原发灶TL-PSMA、转移灶TL-PSMA、全身病灶TL-PSMA均不相关(rs=0.069,P=0.675;rs=0.194,P=0.237;rs=0.299,P=0.064;rs=0.300,P=0.063).结论 反映初诊PCa患者全身肿瘤负荷的代谢体积参数TL-PSMA与血清PSA呈正相关,而与反映原发灶分化程度的GS不相关.  相似文献   
10.
2015—2017年广西卫生资源配置现状及公平性研究   总被引:1,自引:0,他引:1  
目的:分析2015—2017年广西卫生资源配置及公平性情况,为进一步优化卫生资源配置提供参考。方法:采用洛伦兹曲线、基尼系数和泰尔指数从人口、地理、经济三个维度评价广西卫生资源配置公平性。结果:2015—2017年,广西卫生资源拥有量呈上升趋势;人口维度上洛伦兹曲线弯曲度最小,地理维度上弯曲度最大。2015年、2017年各项卫生资源在人口维度上基尼系数值的范围分别为0.0608~0.1505、0.0965~0.1494,地理维度上分别为0.2807~0.3114、0.2892~0.3336,经济维度上分别为0.1160~0.2610、0.1928~0.3079,泰尔指数分析结果显示,2017年各项卫生资源的总泰尔指数位于0.0148~0.1829之间,在人口与经济维度上多表现为组内贡献率>组间贡献率,地理维度上表现为组间贡献率>组内贡献率。结论:2015—2017年,广西卫生资源总量增加,但部分卫生资源配置不公平情况加剧,地区分布不均衡,按人口和经济配置的卫生人力资源公平性较好,但按地理配置的公平性有待提高。建议强化政府在卫生资源配置中的作用,改善地区间分布差异,使资源向落后、偏远地区倾斜,同时实施区域人才稳定政策。  相似文献   
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