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排序方式： 共有1511条查询结果，搜索用时 27 毫秒
1.
Luo Xiao dong Wang Peng Li Zhe Liang De Huang Feng Liu Jinwen Chen Xinyu Hu Guoheng Fang Suting Zhang Huajian 《中医杂志(英文版)》2017,37(2):193-200
Objective
To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.Methods
This was a multicenter, single-blind, randomized, controlled trial. From April 2002 to November 2003, 499 patients were randomly assigned to either the treatment or the control group. The treatment group was orally administered granules prepared with a formula for cervical spondylosis, while the control group was given Jingfukang granules. The treatment course was 1 month for both groups.Results
In patients with the nerve root type of cervical spondylosis, the total effect rate in the treatment group (87.21%) was significantly higher than that in the control group (80.70%, P < 0.01). After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of pain, numbness of the upper limbs, muscle strength of the upper limbs, and fatigue than the control group (all P < 0.05). In patients with the vertebral artery type of cervical spondylosis, the total effect rate in the treatment group (82.07%) was similar to that in the control group (71.21%, P > 0.05). After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of weakness of the waist and knees than the control group (P < 0.05).Conclusion
The cervical spondylosis formula granules significantly improve numbness, muscle strength, and fatigue, and reduce pain in patients with the nerve root type of cervical spondylosis, and improve the weakness of the waist and knees in patients with the vertebral artery type of cervical spondylosis. 相似文献2.
Gao Hui Xia Tian Ma Ruihong Zhao Zhimei Song Xueru Wang Baojuan Liu Lijing Han Kaimei Wang Guoqing Fu Yu Hao Guimin 《中医杂志(英文版)》2017,37(4):530-537
Objective
To evaluate the clinical efficacy and safety of Heyan Kuntai capsule (HYKT) in treating women with infertility caused by diminished ovarian reserve (DOR).Methods
One hundred eight eligible patients from three Chinese hospitals were randomly divided into an HYKT treatment group (n = 55) ora dehydroepiandrosterone (DHEA) treatment group (n = 53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a 3-month period.Results
Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment (P < 0.05) especially in the HYKT group (P < 0.05). Serum follicle stimulating hormone (FSH) levels and FSH/luteinizing hormone ratios decreased (P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased (P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively (not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer (IVF-ET) and the number of retrieved oocytes was (5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was (4.2 ± 1.9) (not significant); clinical pregnancy rates were 38% in the HYKT group and 20% in DHEA group (not significant). No significant adverse reactions were observed.Conclusion
HYKT can improve the ovarian reserve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA treatment. HYKT might be an alternative to the treatment of infertility caused by DOR. 相似文献3.
Jiang Junjie Zhang Yin Xie Yanming Li Yuan Sun Shuailing Zhang Yili Wang Shuo Zhu Yong Qi Wensheng 《中医杂志(英文版)》2017,37(5):621-628
Objective
To observe the curative effect of Jinye Baidu granule in the treatment of fever and swollen and sore throat caused by wind-warmth lung-heat disease (heat in the lung-wei) to further identify the indications.Methods
This randomized, double-blind, parallel, controlled trial will include patients with acute upper respiratory infection and wind-warmth lung-heat disease (heat in the lung-wei). Patients with serious bacterial infection (white blood cell count > 12 × 109, neutrophils > 80%) will be excluded. Patients will be divided into three categories (blocks) according to their condition: fever only, a swollen and sore throat, and combined fever plus a swollen and sore throat. Patients within each of the three blocks will be further divided into a treatment group and a control group via stratified blocked randomization. The treatment group will be treated with Jinye Baidu granule, and the control group will be treated with Fufang Shuanghua granule. The primary outcome measure will be body temperature recovery time for patients with fever, throat symptom score for patients with a swollen and sore throat, and body temperature recovery time and throat symptom score for patients with combined fever plus a swollen and sore throat. Routine blood testing, urine testing, liver function, kidney function and ECG data of all patients will be collected as safety indices before and after enrollment, and adverse events will be recorded during the whole trial course.Conclusion
This study protocol will include stratified block analysis according to patients' symptoms, and identify the accurate clinical indications of Jinye Baidu granule. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment. 相似文献4.
Wu Lingling Liu Xiaohui Yin Yuzhu Sun Ke Wu Ling Yi Wei Li Shangrong Hou Hongying 《中医杂志(英文版)》2017,37(5):629-635
Objective
To evaluate the effectiveness of acupuncture analgesia (AA) compared with combined spinal-epidural anesthesia (CSEA) for labor pain relief and labor outcomes.Methods
We evaluated 131 primiparous women who received respiratory guidance during maternal uterine contractions and received either AA (n = 43), CSEA (n = 45), or no additional treatment (control, n = 43). The groups were compared regarding visual analog scale (VAS) scores for abdominal and back pain, and labor outcomes.Results
The abdominal VAS scores of the AA and CSEA groups were significantly lower than that of the control group. In addition, the VAS scores of the CSEA group were significantly lower than that of the AA group at 10 and 60 min after intervention. The back pain VAS scores of the AA and CSEA groups were significantly lower than that of the control group at 5, 10, and 60 min after intervention. The duration of the active phase of labor in the CSEA group was significantly longer than that of the AA and control groups. The rates of oxytocin use (4.70%), urinary retention (4.70%), and postpartum hemorrhage (273.72 ± 53.63 mL) in the AA group were significantly lower than in the CSEA group (46.70%, 24.20%, and 320.00 ± 85.60 mL, respectively).Conclusion
Both AA and CSEA were effective for labor pain relief, CSEA provided more effective pain relief, while AA was associated with a shorter duration of labor and fewer adverse effects.and each has its advantages and disadvantages. 相似文献5.
Chen Pei Zhang Yong Ling Lili Chen Xing Ren Yi Jiang Lan Wu Shuang Wang Wenting Wang Yuguang Zou Yihuai 《中医杂志(英文版)》2017,37(6):810-818
Objective
To investigate the efficacy and safety of Xinglouchengqi (XLCQ) decoction in treatment of acute ischemic stroke with constipation.Methods
In this prospective, multicenter, assessor-blinded, randomized controlled trial, 360 eligible participants will be randomized to the XLCQ group or the control group. Participants in the XLCQ group will receive XLCQ decoction, while those in the control group will undergo clysis therapy using glycerin enemas or oral administration of lactulose solution. Both groups will undergo a treatment period of (5 ± 2) d and a 1-month follow-up. The primary outcome measure will be the Constipation Scale score. The secondary outcome measures will include scores on the National Institutes of Health Stroke Scale, the Traditional Chinese Medicine (TCM) Stroke Scale, the Diagnostic Scale for TCM Syndromes of Ischemic Stroke and TCM Scale for Syndrome of Phlegm-heat and Fu-organ Excess. Therapeutic mechanism outcomes and safety outcomes will also be assessed. Assessments will be conducted at baseline, at the end of the treatment period, and at the follow-up. Moreover, daily visits will be scheduled to grade the status of constipation during the treatment period.Discussion
The results of this study will provide scientific and objective data with which to assess the efficacy and safety of XLCQ decoction for patients with acute ischemic stroke and constipation. 相似文献6.
OBJECTIVE
To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) on the neutrophil-to-lymphocyte ratio (NLR) and quality of life in patients with non-small-cell lung cancer (NSCLC).METHODS
Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) every day for 6 weeks, while group B received no intervention (control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.RESULTS
Five participants dropped out, leaving a final total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B (P < 0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life (P < 0.001) and function (P < 0.05), and significantly lower in terms of symptoms (P < 0.05).CONCLUSION
The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli (ST 36) and Feishu (BL 13) effectively decreases the NLR and improves the quality of life in patients with NSCLC. 相似文献7.
目的 通过治疗后的治疗有效率、不良反应发生率等进行Meta分析,评价聚桂醇治疗下肢静脉曲张的有效性和安全性.方法 计算机检索CBM、CNKI、万方、pubmed等数据库,纳入聚桂醇治疗下肢静脉曲张的随机对照实验,并对纳入研究的方法学质量进行系统评价,并应用RevMan5.2软件进行统计分析.结果 共纳入16个随机对照试验.Meta分析结果表明:有效治疗率比较显示聚桂醇治疗组较对照组更为有效,合并治疗有效率效应量RR=5.80[2.76,12.18](95％CI),P＜0.00001,明显有统计学意义;安全性比较分析显示说明聚桂醇试验组的安全性高于对照组,不良反应的数据合并效应量RR=0.25[0.15,0.39](95％CI),P＜0.00001,明显有统计学意义.但由于纳入的文献相对较少,质量不高,存在发表偏移,故仍需要扩大样本量及加长随访时限等来完善研究.结论 基于纳入16项文献的Meta分析结果,认为聚桂醇治疗下肢静脉曲张是具有疗效的,并且在一定程度上可减少不良反应发生率.结论 对治疗下肢静脉曲张的临床用药有一定的参考性. 相似文献
8.
目的：评价坦度螺酮辅助治疗非糜烂性反流病的临床疗效。方法整群选取该院收治的167例非糜烂性反流病患者，随机分为治疗组81例和对照组86例，对照组采用泮托拉唑联合莫沙比利治疗，治疗组在对照组基础上加用坦度螺酮。观察治疗后两组患者临床疗效以及RDQ评分。结果治疗结束后治疗组总有效率为90.38%，对照组为70.24%，治疗组总有效率高于对照组（P<0.05）；两组治疗后烧心、反酸、胸痛、反食等症状均有所改善，治疗组RDQ评分明显低于对照组（P<0.05）；两组均无明显不良反应发生。结论坦度螺酮辅助治疗非糜烂性反流病临床疗效明显，推荐用于合并焦虑抑郁情绪患者。 相似文献
9.
目的 观察神经生长因子治疗周围神经损伤的临床疗效.方法 纳入60例周围神经损伤患者,采用随机数字表法分为2组.试验组30例采用鼠NGF肌内注射治疗,对照组30例采用维生素B12治疗,治疗4周后观察疗效.观察指标包括疼痛(VAS)、麻木等临床症状和体征,同时观察单神经的神经电生理情况.结果 疼痛改善:试验组总有效率93.33％,对照组为53.33％;麻木改善:试验组总有效率86.67％,对照组为66.67％;2组比较差异均有统计学意义(P＜0.05).试验组恢复神经的感觉及运动电位的潜伏期时间均明显短于对照组,差异有统计学意义(P＜0.05);而波幅则均显著高于对照组,差异有显著性意义(P＜0.05).结论 神经生长因子能有效改善患者的疼痛、麻木症状,而且能对神经纤维的修复、电生理功能有促进作用. 相似文献
10.
目的 使用荟萃分析方法汇总所有的随机对照研究,比较不同放射性活度131I清除术后残留甲状腺(清甲)的成功率,明确最佳的清甲剂量.方法 以‘thyroid’+‘cancer or carcinoma’+‘ablat$’(包括了ablation、ablative和ablate)为关键词检索2014年3月前Cochrane Library、MEDLINE、EMBASE和SCOPUS等数据库评估不同放射性活度”1 I清甲成功率的随机对照研究文献,并用Google学术查找相关文献.用RevMan 5.2进行统计学分析,依据Cochrane质量评价标准进行文献质量评估.纳入标准如下:(1)已发表的比较不同剂量131I对分化型甲状腺癌(DTC)清甲成功率的研究.(2)患者均行甲状腺切除术.(3)均为术后首次131I治疗.(4)服131I后3～12个月行清甲成功率评估.(5)服131I剂量为888 ～4 440 MBq(24～120 mCi).本研究定义低剂量为888～1 443 MBq(24～39 mCi)、中剂量为1 480～2 923 MBq(40 ～79 mCi)、高剂量为2 960～4 440 MBq(80～120 mCi).当研究间存在异质性时(I2＞50％)、采用随机效应模型进行荟萃分析,否则采用固定效应模型进行荟萃分析.结果 共纳入17个随机对照研究,包括3 737例患者(低剂量1 514例、中剂量811例、高剂量1 412例).5项研究比较了低剂量与中剂量的成功率,研究间有异质性(I2 =67％,P=0.02)、采用随机效应模型,荟萃分析结果显示两组的清甲成功率差异无统计学意义[风险比(RR) =0.89(0.80～1.00),P=0.06].7项研究比较了中剂量与高剂量的成功率,研究间无异质性(I2=34％,P=0.17),采用固定效应模型,荟萃分析结果显示两组剂量的清甲成功率差异无统计学意义[RR =0.94(0.89～1.00),P=0.05].11项研究比较了低剂量与高剂量的成功率,研究间有异质性(I2=70％,P=0.0002),采用随机效应模型,荟萃分析结果显示高剂量的清甲成功率显著高于低剂量[RR=0.89(0.81 ～0.97),P=0.008].结论 对于术后DTC患者,低剂量与中剂量131I以及中剂量与高剂量131I的清甲成功率无明显差异,但高剂量131I的清甲成功率显著高于低剂量. 相似文献