全文获取类型
收费全文 | 24217篇 |
免费 | 2553篇 |
国内免费 | 944篇 |
专业分类
耳鼻咽喉 | 442篇 |
儿科学 | 476篇 |
妇产科学 | 583篇 |
基础医学 | 1271篇 |
口腔科学 | 158篇 |
临床医学 | 2438篇 |
内科学 | 4068篇 |
皮肤病学 | 153篇 |
神经病学 | 1499篇 |
特种医学 | 507篇 |
外科学 | 3546篇 |
综合类 | 3908篇 |
预防医学 | 887篇 |
眼科学 | 108篇 |
药学 | 1374篇 |
8篇 | |
中国医学 | 115篇 |
肿瘤学 | 6173篇 |
出版年
2024年 | 68篇 |
2023年 | 404篇 |
2022年 | 1044篇 |
2021年 | 1352篇 |
2020年 | 1281篇 |
2019年 | 1012篇 |
2018年 | 1001篇 |
2017年 | 945篇 |
2016年 | 1049篇 |
2015年 | 1032篇 |
2014年 | 2015篇 |
2013年 | 1626篇 |
2012年 | 1727篇 |
2011年 | 1804篇 |
2010年 | 1375篇 |
2009年 | 1326篇 |
2008年 | 1297篇 |
2007年 | 1242篇 |
2006年 | 1110篇 |
2005年 | 872篇 |
2004年 | 721篇 |
2003年 | 594篇 |
2002年 | 432篇 |
2001年 | 438篇 |
2000年 | 386篇 |
1999年 | 336篇 |
1998年 | 223篇 |
1997年 | 180篇 |
1996年 | 133篇 |
1995年 | 115篇 |
1994年 | 82篇 |
1993年 | 57篇 |
1992年 | 63篇 |
1991年 | 52篇 |
1990年 | 41篇 |
1989年 | 36篇 |
1988年 | 42篇 |
1987年 | 31篇 |
1986年 | 15篇 |
1985年 | 34篇 |
1984年 | 26篇 |
1983年 | 9篇 |
1982年 | 20篇 |
1981年 | 7篇 |
1980年 | 18篇 |
1979年 | 11篇 |
1978年 | 6篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1972年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
A. G. D. Maran J. A. Wilson M. N. Gaze 《European archives of oto-rhino-laryngology》1993,250(3):127-132
Summary Squamous cell carcinoma of the head and neck is a disease predominantly of males and is due to a variety of known environmental irritants, notably cigarette smoke. Dietary, viral and immunological factors may also be relevant. Head and neck squamous cancers express epidermal growth factor receptors and some show weak levels of oestrogen receptor activity, but a reliable serum marker of tumour burden remains to be identified. The prognosis is found to be less favourable in females, in those with advanced T stage, in association with multiple node involvement, especially where extracapsular spread is present and where the T4/T8 ratio is elevated. Administration of heterologous blood during therapy may also have an adverse effect on prognosis. Interested clinicians must remember that most cases are preventable.
Correspondence to: A.G.D. Maran 相似文献
2.
儿童无症状尿检异常IgA肾病的临床病理和预后分析 总被引:2,自引:0,他引:2
目的 探讨儿童无症状尿检异常的IgA肾病的临床病理特征和预后。 方法 对54例IgA肾病儿童的临床和病理特征进行分析。根据起病时有无临床症状分为无症状尿检异常组和有症状肾炎组。组织病理学分级参照Lee氏和Katafuchi氏半定量积分法。 结果 无症状尿检异常组18例,有症状肾炎组36例。有症状肾炎组尿蛋白量(24 h)明显高于无症状尿检异常组[(2.3±2.2) g比(0.4±0.3) g,P < 0.05]。无症状尿检异常的IgA肾病儿童表现为镜下血尿者,87%有尿微量白蛋白增高。无症状尿检异常IgA肾病患儿病理表现以Lee 氏Ⅰ~Ⅱ级为主,2例表现为Lee氏Ⅳ~Ⅴ级和 5例发生Katafuchi Ⅱ~Ⅲ级肾小管间质病变。有症状肾炎组Lee氏病理分级以Ⅱ~Ⅲ级为主,两者病理分级分布差异无统计学意义(P > 0.05)。全组患儿平均随访(26.9±8.8)月后,1例病理为Lee 氏Ⅴ级患儿进入终末期肾衰竭,其余患儿Scr均无升高1倍以上。 结论 无症状尿检异常的儿童IgA肾病虽临床症状轻微,但可出现病理损害严重的病例,并影响其预后。 相似文献
3.
Michelle L. DeOliveira Timothy M. Pawlik Ana L. Gleisner Lia Assumpcaom Gaspar J. Lopes-Filho Michael A. Choti 《Journal of gastrointestinal surgery》2007,11(8):970-976
Survival after resection of colorectal liver metastases has traditionally been associated with clinicopathologic factors.
We sought to investigate whether echogenicity of colorectal liver metastasis as assessed by intraoperative ultrasound (IOUS)
was a prognostic factor after hepatic resection. Prospective data on tumor IOUS appearance were collected in 84 patients who
underwent hepatic resection for colorectal liver metastasis. Images were digitally recorded, blindly reviewed, and scored
for echogenicity (hypo-, iso-, or hyperechoic). The median tumor number was 1 and the median tumor size was 5.0 cm. At the
time of surgery, the IOUS appearance of the colorectal liver metastases were hypoechoic in 35 (41.7%) patients, isoechoic
in 37 (44.0%) patients, and hyperechoic in 12 (14.3%) patients. Traditional clinicopathologic prognostic factors were similarly
distributed among the three echogenicity groups (all p > 0.05). Patients with a hypoechoic lesion had a significantly shorter median survival (30.2 months) compared with patients
who had either an isoechoic (53.2 months) or hyperechoic (42.3 months) lesion (p = 0.005). The 5-year survival after hepatic resection of colorectal liver metastasis was also associated with the echogenic
appearance of the lesion (hypoechoic 14.4 vs isoechoic 37.4 vs hyperechoic 46.2%) (p < 0.05). Intraoperative ultrasound echogenicity should be considered a prognostic factor after hepatic resection of metastatic
colorectal cancer.
This study was presented at the 47th annual meeting of The Society for Surgery of the Alimentary Tract, Los Angeles, CA, USA,
22 May 2006. 相似文献
4.
伴肝转移的Ⅳ期胃癌手术方式的合理选择 总被引:1,自引:0,他引:1
目的探讨不同手术方式对伴肝转移的Ⅳ期胃癌患者的临床疗效。方法回顾性分析1993-2004年间102例伴肝转移的Ⅳ期胃癌病例的手术方式,评价不同术式对预后的影响。结果肝转移H1的胃癌病例行姑息切除后半年、1年和2年的生存率分别为69%、44%和6%,与改道手术、开腹探查术者的生存率比较,差异有统计学意义(P=0.009)。肝转移H2的胃癌病例姑息切除术后半年、1年和2年的生存率分别为56%、13%和6%,与改道手术、开腹探查术者的生存率比较,差异无统计学意义(P=0.068)。肝转移H3的胃癌病例行姑息切除半年、1年和2年的生存率分别为25%、13%和0,与改道手术、开腹探查术者的生存率比较,差异无统计学意义(P=0.157)。有或无腹膜转移的病例,其术后生存率比较,差异亦无统计学意义(P=0.132)。结论肝转移H1的胃癌患者,无论伴与不伴腹膜转移,均应尽量行姑息性切除手术。肝转移H2、H3的Ⅳ期胃癌患者行切除性手术无益于预后。 相似文献
5.
6.
7.
目的 探讨肿瘤微血管密度(MVD)与肝细胞性肝癌临床病理及预后的关系。方法对30例肝细胞性肝癌根治性切除病理组织切片进行苏木精伊红染色.并用CD34单克隆抗体进行免疫组化染色,计数被CD34抗体染色的肿瘤血管内皮细胞数,以测定MVD。对MVD与临床病理因素及术后生存率关系进行分析。结果 单因素分析结果表明.MVD水平与肿瘤大小、TNM分期都是影响肝细胞性肝癌预后的因素;多因素分析结果表明.肝癌大小及肿瘤分期是肝细胞性肝癌独立预后因素。结论 MVD是肝细胞性肝癌一种预后因素。 相似文献
8.
9.
重型颅脑损伤持续颅内压及脑灌注压监护与预后关系 总被引:2,自引:0,他引:2
作者对50例重型颅脑损伤患者(GCS3-8分),及50例伤情与诊断和手术方式基本相似的另一组患者进行颅内压(ICP)与脑灌注压(CCP)连续监测对比研究。结果表明,监护组除8例ICP压力<2.00kPa,CPP>9.33kPa外,余42例均有不同程度ICP增高与CPP降低。这些患者分别为创伤性颅内血肿、广泛性脑挫裂伤、继发性脑水肿或脑肿胀等,均采取积极的手术及综合治疗。死亡率为14%。非监护组治疗方法与监护组相同,预后较差且并发症多,死亡率为28%。作者认为,对重型颅脑损伤患者施行连续ICP、CPP监护,是降低并发症和死亡率,提高疗效的有力措施,具有重要的临床应用价值。 相似文献
10.
N Dubosc-Marchenay F Lacombe P Dumain G Marit M Montastruc F Belloc J Reiffers 《Hematological oncology》1992,10(5):235-249
Bone marrow blast cell antigen expression from 86 patients with de novo acute myeloid leukemias (AML) was studied and correlated with FAB classification and clinical outcome. Among a panel of 14 monoclonal antibodies routinely used for the diagnosis of acute leukemias we studied the expression of six antibodies (CD13, CD15, VIM2, CD33, CD14, CD34) of the granulomonocytic lineage and found that some of them were useful for diagnosis and/or prognosis. For FAB subclassification of AML, the CD13 or VIM2 antigen expression was of no benefit. Monocytic leukemias (M4 + M5PD + M5WD) more frequently expressed CD34 antigen (28/31) than granulocytic (M1 + M2 + M3) subtypes (33/53) (P < 0.01). Finally, the most striking differences were found with CD14 antigen expression: CD14 antigen was more frequently expressed in M4 + M5 leukemias (21/31) than in M1 + M2 + M3 subtypes (12/33) (P < 0.01). The mean percentage of CD14 positive blast cells was accordingly higher in monocytic leukemias than in granulocytic leukemias and the difference was highly significant (P < 0.0001). The CD15 antigen was more frequently expressed in differentiated leukemias (M2 + M3 + M4 + M5WD) (35/44) than in poorly differentiated forms (M1 + M5PD) (17/37) (P < 0.001). The statistical difference was higher when the mean percentage of CD15 positive blast cells were compared (P < 0.0003). Moreover these latter percentages were different in M1 and M2 subtypes (P < 0.003). The blast cell expression of CD13, CD14, CD15 or CD33 was not predictive of the length of CR or survival. Moreover, our results support previously published findings suggesting a longer overall survival duration for patients whose leukemic cells do not express the CD34 antigen (P < 0.01). We also confirm that patients with the more differentiated subtypes of AML (CD13-, CD34+) tend to survive longer than patients with the less differentiated subtypes of AML (CD13-, CD34+) (P < 0.001). 相似文献