全文获取类型
收费全文 | 977篇 |
免费 | 39篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 6篇 |
妇产科学 | 29篇 |
基础医学 | 47篇 |
口腔科学 | 14篇 |
临床医学 | 36篇 |
内科学 | 130篇 |
皮肤病学 | 3篇 |
神经病学 | 33篇 |
特种医学 | 21篇 |
外科学 | 47篇 |
综合类 | 201篇 |
预防医学 | 48篇 |
药学 | 378篇 |
1篇 | |
中国医学 | 32篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 1篇 |
2022年 | 7篇 |
2021年 | 17篇 |
2020年 | 16篇 |
2019年 | 5篇 |
2018年 | 13篇 |
2017年 | 11篇 |
2016年 | 12篇 |
2015年 | 32篇 |
2014年 | 76篇 |
2013年 | 77篇 |
2012年 | 63篇 |
2011年 | 52篇 |
2010年 | 38篇 |
2009年 | 38篇 |
2008年 | 25篇 |
2007年 | 34篇 |
2006年 | 33篇 |
2005年 | 27篇 |
2004年 | 24篇 |
2003年 | 28篇 |
2002年 | 29篇 |
2001年 | 26篇 |
2000年 | 21篇 |
1999年 | 13篇 |
1998年 | 15篇 |
1997年 | 21篇 |
1996年 | 28篇 |
1995年 | 20篇 |
1994年 | 31篇 |
1993年 | 21篇 |
1992年 | 35篇 |
1991年 | 18篇 |
1990年 | 19篇 |
1989年 | 10篇 |
1988年 | 12篇 |
1987年 | 15篇 |
1986年 | 16篇 |
1985年 | 10篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 10篇 |
1981年 | 5篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 1篇 |
排序方式: 共有1033条查询结果,搜索用时 968 毫秒
1.
John G. Larkin George G. Thompson Gordon Scobie Joan E. Drennan Martin J. Brodie 《Epilepsia》1991,32(5):729-734
Interaction with adenosine A1 receptors is a possible contributory mechanism to the anticonvulsant effects of carbamazepine (CBZ) and the dihydropyridine calcium antagonists. We measured the binding of [3H]cyclohexyladenosine to adenosine A1 receptors in mouse brain stem, cerebellum, and cortex after oral administration of nifedipine, nimodipine (NMD), and CBZ for 7 days and compared the results with binding in control mice. Equilibrium dissociation constant (Kd) and receptor numbers (Bmax) were calculated using Scatchard and saturation isotherm analyses. Mean Kds (SEM) in control brain stem, cerebellum, and cortex were 2.09 (0.31), 2.39 (0.2), and 3.12 (0.28) nM, respectively. Results of Bmax for the same areas were 188 (26), 280 (24), and 449 (54) fmol/mg protein. Nifedipine (p less than 0.005) and NMD (p less than 0.02) raised the Kd of A1 receptors only in the cerebellum, and CBZ increased cerebellar Bmax (p less than 0.05). These minor effects on A1 receptors in CF1 mice, when given in doses previously shown to have anticonvulsant properties in these animals, do not suggest that alteration in A1 receptor activity is an important mechanism for the anticonvulsant effects of these drugs. 相似文献
2.
Influence of Preparation Factors on the Sustained Release of Nifedipine from Eudragit RL/RS Microspheres 总被引:1,自引:0,他引:1
用乳剂—溶剂挥发法制备硝苯地平的丙烯酸树脂缓释微球。微球中药物的释放速度随丙烯酸树脂EudragitRL/RS比率的增加以及制备时搅拌速率的增加而增大,随内相聚合物浓度的增加及微球粒径的增加而减小,释药50%所需时间与微球粒径呈良好线性。微球的释药速率也随药物含量的增加(从4.2%到16.7%)而增大,并快于药物结晶的溶解速率,但药物含量达26.6%时,微球释药速率明显下降并低于药物结晶的溶解速率。用差热分析和X射线衍射分析证明,药物含量为4.2,9.4和16.7%的微球中药物完全是以非晶态分散的,而含药26.6%的微球中有药物结晶存在。不同微球释药低于70%时,释放方式均符合Higuchi时间平方根方程。 相似文献
3.
R. Schall F. O. Müller H. K. L. Hundt L. Duursema G. Groenewoud M. Van Dyk A. M. C. Van Schalkwyk 《Biopharmaceutics & drug disposition》1994,15(6):493-503
Four controlled-release nifedipine products were investigated in two clinical studies. In study 1, 22 healthy male volunteers took part in an open, multiple-dose, randomized, crossover study to determine the relative bioavailablity of two 10 mg controlled-release nifedipine tablet (Adalat® Retard, Bayer), administered 12 hourly, and one 20 mg controlled-release nifedipine tablet (Adalat® Retard, Bayer) administered 12 hourly. In study 2, 24 healthy male volunteers took part in an open, multiple-dose, randomized, three-period, crossover study to determine the relative bioavailability of (i) two 30 mg nifedipine gastro-intestinal therapeutic system (GITS) tablets (Adalat® XL, Bayer) administered once daily; (ii) one 60 mg nifedipine GITS tablet (Adalat® XL, Bayer) administered once daily; and (iii) one 20 mg plus one 10 mg nifedipine controlled-release tablet (Adalat® Retard, Bayer), administered 12 hourly. In both studies detailed pharmacokinetic data, in particular with respect to the controlled-release characteristics of the different formulations, were collected. Results of both studies indicate that all nifedipine products investigated are bioequivalent with respect to the extent of absorption of nifedipine. The nifedipine GITS products (Adalat® XL) have better controlled-release properties than the Adalat® Retard product, and are suitable for once-a-day administration. 相似文献
4.
Summary The effectiveness of nifedipine retard as a treatment for Raynaud's phenomenon was assessed in 15 patients in a placebo controlled double blind study. An associated connective tissue disease was evident in 7 patients. Changes in finger and forearm blood flow (venous occlusion plethysmography), digital skin temperature and digital systolic pressure were measured acutely before and after a 2-week treatment period. Subjective assessment of efficacy was based on patient diary data. In addition alpha2-adrenoceptor density on platelets was measured before and after chronic nifedipine therapy in both the patient group and in an age-and-sex-matched control group. No significant haemodynamic changes were observed. Nifedipine retard significantly reduced the frequency (p<0.05) with no change in either the duration or severity of vasospastic attacks. Side effects were commono following nifedipine retard. A reduction in alpha2-adrenoceptor density on platelets was observed in patients compared to a control group (p<0.05). Alpha2-adrenoceptor density was unchanged following a 2-week treatment period with nifedipine retard. This study concludes that nifedipine retard is not effective in the treatment of Raynaud's phenomenon over a short time course. Patients with Raynaud's phenomenon have reduced alpha2-adrenoceptor densities on their platelets. 相似文献
5.
Arend Bökenkamp Bettina Bohnhorst Christian Beier Norbert Albers Gisela Offner Johannes Brodehl 《Pediatric nephrology (Berlin, Germany)》1994,8(2):181-185
Gingival hyperplasia is a common side-effect of immunosuppression with cyclosporine A. Nifedipine is often used to control hypertension in kidney graft recipients. Analysis of gingival status in 106 children transplanted at our centre, and treated either with azathioprine, cyclosporine A or both, revealed significantly higher degrees of gingival overgrowth in those children receiving a combination of cyclosporine A and nifedipine compared with those children treated with cyclosporine A or nifedipine alone. Seven children undergoing gingivectomy at our centre over the past few years had received this combination. After a change in the antihypertensive regimen, avoiding long-term nifedipine medication, and improved dental care with chlorhexidine gel, we noted a reduction in the degree of gingival hyperplasia. In the majority of patients, nifedipine could be replaced by a single drug, usually hydralazine. We therefore recommend avoiding calcium channel blockers in the long-term management of hypertension in patients receiving cyclosporine. 相似文献
6.
B. N. Purdue G. C. A. Fernando A. Busuttil 《International journal of legal medicine》1991,104(5):289-291
Summary An incident is reported in which 2 intravenous drug abusers died as the result of uncontrolled experimentation with intravenous injection of the common anti-hypertensive and anti-anginal drug Nifedipine (Adalatt.m. Bayer), probably in mistake for the commonly abused short-acting benzodiazepine drug Temazepam. Large quantities of Nifedipine were identified in the blood of both deceased men by gas chromatography. Apart from intense gastric mucosal congestion, pulmonary oedema and general visceral congestion, the autopsy findings were entirely nonspecific. The similarity in colour, shape and texture between capsules of Nifedipine and those of Temazepam is likely to have prompted the mistake. 相似文献
7.
132例高血压病患者随机分为二组,观察组76例采用脉君安与巯甲丙脯酸、硝苯吡联合应用。对照组56例采用巯甲丙脯酸、硝比啶联合应用。共用4周,结果降压总有依次为97.36%、85.71%;副作用发生率依次为2.63%、,17.86%。未见明显的电解质、血糖和血脂变化,提示脉群安与巯甲丙酸,硝苯吡啶联合应用可以提高降压疗效减少副作用。 相似文献
8.
Stanley G. Rane George G. Holz IV Kathleen Dunlap 《Pflügers Archiv : European journal of physiology》1987,409(4-5):361-366
Dihydropyridine (DHP) calcium channel antagonists, which inhibit the slowly inactivating or L-type cardiac calcium (Ca) current, have been shown to be ineffective in blocking45Ca influx and Ca-dependent secretion in a number of neuronal preparations. In the studies reported here, however, the antagonist DHP nifedipine inhibited both the L-type Ca current and potassium-evoked substance P (SP) release from embryonic chick dorsal root ganglion (DRG) neurons. These results suggest that, in DRG neurons. Ca entry through L-type channels is critical to the control of secretion. The inhibition of Ca current by nifedipine was both voltage and time-dependent, significant effects being observed only on currents evoked from relatively positive holding potentials maintained for several seconds. As expected from these results, nifedipine failed to inhibit L-type Ca current underlying the brief plateau phase of the action potential generated from the cell's normal resting potential; likewise, no significant effect of the drug was observed on action potential-stimulated SP release evoked by electrical field stimulation. The results of this work are discussed in terms of an assessment of the role of L-type Ca channels in neurosecretion.This work was supported by United States Public Health Service Grant NS16483 (KD) and by a USPHS Postdoctoral Fellowship (SGR) 相似文献
9.
Summary The role of Ca channel and extracellular Ca2+ on autoregulation of renal blood flow was investigated in the perfused kidney of the anesthetized dog. The perfusion pressure was changed in the range between 60 and 200 mm Hg. Intra-arterial infusion of nifedipine (5 g/min) increased renal blood flow at a perfusion pressure above 100 mm Hg and inhibited autoregulation. Simultaneous infusion of 5 g/min of BAY K 8644 antagonized the effect of nifedipine. Renal blood flow was increased and autoregulatory relationship between flow and perfusion pressure was inhibited by EDTA (30 mg/min) infusion. The inhibitory effect of EDTA on renal autoregulation was counteracted by simultaneous infusion of CaCl2 at 30 mg/min, but not counteracted by that of BAY K 8644 (5 g/min). BAY K 8644 also could not antagonize the inhibitory effect of a vasodilator, papaverine (5 mg/min) on renal blood flow autoregulation. These results provide the evidence that the renal autoregulation involves the process of Ca2+ influx into the vascular smooth muscle cell through the Ca channels.
Send offprint requests to N. Ogawa at the above address 相似文献
10.
目的:探讨硝苯地平联合拉贝洛尔治疗对子痫前期患者可溶性Fms样酪氨酸激酶–1(sFlt–1)及胎盘生长因子(PLGF)浓度的影响。方法:选择2021年4月至2022年4月于郑州大学第一附属医院诊治的380例子痫前期患者,根据简单随机法分成观察组、对照组,各190例。对照组患者给予硫酸镁联合硝苯地平治疗,观察组患者在对照组基础上联合拉贝洛尔治疗,比较两组患者治疗前、治疗14 d后血液/尿液指标[尿肌酐(UCr)、24 h尿蛋白定量(24h UPQ)、血清脑利尿钠肽(BNP)、sFlt–1、PLGF]、血压[收缩压(SBP)、舒张压(DBP)]、超声检查指标[血流阻力指数(RI)、脐动脉血流速度峰谷比(S/D)与搏动指数(PI)]以及妊娠结局。结果:观察组患者治疗后UCr、24h UPQ、血清BNP、s Flt–1水平、SBP、DBP、RI、PI、S/D均低于对照组,血清PLGF水平高于对照组,差异具有统计学意义(P <0.05);观察组不良妊娠结局总发生率为13.16%,低于对照组的25.26%,差异具有统计学意义(P <0.05)。结论:子痫前期患者联合应用硝苯地平与拉贝洛... 相似文献