全文获取类型
收费全文 | 73290篇 |
免费 | 7017篇 |
国内免费 | 1823篇 |
专业分类
耳鼻咽喉 | 448篇 |
儿科学 | 1895篇 |
妇产科学 | 1476篇 |
基础医学 | 6592篇 |
口腔科学 | 1569篇 |
临床医学 | 8401篇 |
内科学 | 10493篇 |
皮肤病学 | 815篇 |
神经病学 | 6361篇 |
特种医学 | 1109篇 |
外国民族医学 | 7篇 |
外科学 | 5978篇 |
综合类 | 11413篇 |
现状与发展 | 8篇 |
一般理论 | 1篇 |
预防医学 | 13292篇 |
眼科学 | 1120篇 |
药学 | 4731篇 |
49篇 | |
中国医学 | 1770篇 |
肿瘤学 | 4602篇 |
出版年
2024年 | 278篇 |
2023年 | 1413篇 |
2022年 | 2879篇 |
2021年 | 3714篇 |
2020年 | 3563篇 |
2019年 | 2672篇 |
2018年 | 2614篇 |
2017年 | 2722篇 |
2016年 | 3066篇 |
2015年 | 2744篇 |
2014年 | 5431篇 |
2013年 | 5978篇 |
2012年 | 5088篇 |
2011年 | 5314篇 |
2010年 | 4064篇 |
2009年 | 3778篇 |
2008年 | 3706篇 |
2007年 | 3600篇 |
2006年 | 3058篇 |
2005年 | 2522篇 |
2004年 | 2030篇 |
2003年 | 1729篇 |
2002年 | 1429篇 |
2001年 | 1241篇 |
2000年 | 1008篇 |
1999年 | 806篇 |
1998年 | 715篇 |
1997年 | 626篇 |
1996年 | 487篇 |
1995年 | 466篇 |
1994年 | 428篇 |
1993年 | 336篇 |
1992年 | 336篇 |
1991年 | 314篇 |
1990年 | 247篇 |
1989年 | 211篇 |
1988年 | 188篇 |
1987年 | 150篇 |
1986年 | 141篇 |
1985年 | 172篇 |
1984年 | 150篇 |
1983年 | 93篇 |
1982年 | 114篇 |
1981年 | 96篇 |
1980年 | 82篇 |
1979年 | 73篇 |
1978年 | 48篇 |
1977年 | 60篇 |
1976年 | 51篇 |
1975年 | 34篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
周蕾 《国际妇产科学杂志》2015,42(1):91-95
宫颈癌对妇女健康构成严重威胁,人乳头瘤病毒感染与宫颈病变及宫颈癌的发生密切相关。关于宫颈癌发生发展的机制仍在研究中。近年研究发现一种多功能核蛋白,即死亡结构域相关蛋白(death domain associated protein,Daxx),其与细胞内蛋白或病毒蛋白相互作用,参与调节细胞凋亡、转录调控、抗病毒等细胞活动,在不同途径中发挥不同的生理或病理作用。通过对Daxx功能及其作用机制的研究有助于进一步阐明宫颈癌发生发展的机制,有助于发现新的预防和治疗方法。综述Daxx的一般特性和研究现况及其在宫颈病变的研究进展。 相似文献
2.
目的:探究原发性肝癌患者手术切除术后早期复发影响因素分析。方法:对广州市番禺区中医院2017年2月-2019年2月收治的原发性肝癌患者98例进行回顾性分析,依据各项临床指标分析手术切除术后早期复发的影响因素。结果:原发性肝癌患者经由手术切除后出现复发的可能性较高,同时手术切缘有残留、包膜不完整、肿瘤结节、心理因素、甲胎蛋白、血管侵犯、肝硬化及肿瘤直径等均是影响原发性肝癌手术期后再复发的高危因素。结论:原发性肝癌通常具有术后复发的生物学特性,依据对手术切除术之后早期复发因素的分析,对手术风险与治疗方案进行充分评估,同时要求患者进行定期复查及随访等工作,可对患者手术成功以及并发症的防治等均具有积极意义。 相似文献
3.
Camille Veit 《Annales médico-psychologiques》2019,177(4):347-351
Objectives
This paper introduces some epistemology about mental health developments and how it leads to reconsider the landscape of clinical practices.Materials
From an epistemological point of view, the author reviews several writings about mental hygiene going back to the nineteenth century. It clarifies the common roots between mental hygiene and mental health. Then, the article examines the first World Health Organization's reports, that shed light on psychiatric and political issues in the middle of the twentieth century, which allows to reach out the foundations of mental health as a discursive practice.Results
The review of the developments from “mental hygiene” to “mental health” highlights a general climate of redesign on many points: Mental health as a discursive space is characterized by an expansion of its address field. It is not only addressed to specialists, psychiatrist and psychiatric patients, but also, and above all, to every citizen. Psychic suffering, as far as mental illness, is part of a larger whole including what preserves or deteriorates the proper functioning of an individual, within society. Mental health is at the crossroads of financial, political, citizen's rights and social interests. Contemporary mental health relies on the objectives of prevention and promotion. Clinical practices are organized by some discourses with mental health as a key word. At the turn of 2000s, French psychiatry has been impacted by many shuffles in health policies. However, the roots of these restructuring are not new, as they update an old interest in safeguarding public health, funds and welfare. Psychic suffering and mental illness recently enter the field of “psychic disability”. It brought social benefits such as financial assistance from the state. It may also contribute to the campaigns of awareness-raising and destigmatization among the public opinion. However, financial and subjective effects do not perfectly match. In other words, the benefits listed above should not lead to desert the listening of the users’ experience in its singularity.Conclusions
The developments of mental health point out a reorganization in the psychiatric field and open new clinical challenges. If the spaces of singularity and universal are in a permanent relationship, the political and economic sides cannot answer or evacuate the subjectivity posed by the subject and his suffering. It should lead to focus on a clinical practice driven by a subtle listening, which does not exclude psychopathology and recognizes the importance of alterity. 相似文献4.
N. V. Bashmakova G. N. Chistiakova I. A. Gazieva Y. M. Trapeznikova D. O. Mazurov 《Gynecological endocrinology》2015,31(10):31-33
AbstractThis study was undertaken to compare the concentrations of pro- and anti-angiogenic growth factors, nitric oxide (NO) stable metabolites in maternal serum and embryonic left ventricular (LV) isovolumic relaxation time (IRT, ms) during the first trimester in two groups of women: with pregnancy conceived by assisted reproductive technologies (ART, n?=?39) and normally conceived (control group, n?=?68) pregnancy. The concentration of vasoconstrictor endothelin 1 was 45.5 times more in ART than in control group. On the contrary, the concentrations of NO stable metabolites in ART were 1.9 times less than in control women. The assessment of angiogenic suppressors in ART women demonstrates the decrease in s-endoglin concentration was 1.6 times and in soluble receptor to vascular endothelial growth factor concentration was 2.0 times in comparison with control group. There was a significant increase in LV IRT in ART embryos in comparison to control ones. These data suggest significant changes in pro- anti-angiogenic factors balance and increase in vascular impedance in ART-conceived embryos. 相似文献
5.
Takaharu Negoro Kanami Orihara Tomoko Irahara Hiroshi Nishiyama Kanae Hagiwara Risa Nishida Hiroki Takagi Kazue Satoh Yoshiki Yamamoto Shunichi Shimizu Tamio Hagiwara Masakazu Ishii Toshihiro Tanioka Yasuko Nakano Ken Takeda Isao Yoshimura Yoji Iikura Takashi Tobe 《Pediatric allergy and immunology》2006,17(8):583-590
Although many single nucleotide polymorphism (SNP) studies have reported an association of atopy, allergic diseases and total serum immunoglobulin E (IgE) levels, almost all of these studies sought risk factors for the onset of these allergic diseases. Furthermore, many studies have analyzed a single gene and hardly any have analyzed environmental factors. In these analyses, the results could be masked and the effects of other genes and environmental factors may be decreased. Here, we described the correlation between four genes [interleukin (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in connection with IgE production; the role of IL-10 (C-627A) as a regulatory cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) in 220 Japanese allergic children. In addition to these SNPs, environmental factors, i.e., patient's attitude, indoor environment, and so on, were also investigated in this study. Our study was retrospective, and the correlation was analyzed by our defined clinical scores divided into three terms: worst symptoms, recent symptoms and general amelioration at the most recent examination during the disease course. Our results indicated that IL-10 AA, the genotype with lower IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, estimate; 0.912). Marginal liver abnormalities were observed in the subject group with both FA and AE (p < 0.1191, estimate; 0.1490). Our defined clinical scores enabled evaluation of various aspects of disease severity. Based on the scores, while no single SNP selected in this study determined severity, the combination of the SNP with laboratory data and environmental factors appeared to determine severity. 相似文献
6.
7.
疾病是人体对外界事物与环境变化的反应过程,而此过程对机体造成了生理和心理上的重大影响,使机体的正常生理和心理出现失衡状态。要恢复机体的平衡必需要通过相应的措施,特别是针对心理变化的改善对策。良好的心理护理会使疾病的恢复“事半功倍”。 相似文献
8.
颅内肿瘤切除术后颅内感染危险因素分析 总被引:1,自引:0,他引:1
目的 探讨颅内肿瘤切除术后颅内感染的危险因素和预防措施。方法 回顾性分析442例颅内肿瘤切除术患者的临床资料。结果 442例颅内肿瘤切除术患者发生颅内感染33例,感染率为7.47%。非脑膜瘤手术颅内感染率为10.04%,高于脑膜瘤术后颅内感染率3.83%(P〈0.05);手术时间≥4h者颅内感染率为9.87%,高于手术时间〈4h者颅内感染率4.78%(P〈0.05);有脑脊液漏者颅内感染率为15.00%,高于无脑脊液漏者颅内感染率6.28%(P〈0.05);引流管留置≥24h者颅内感染率为11.58%,高于未留置或留置〈24h者颅内感染率5.03%(P〈0.05)。结论 手术时间≥4h、引流管留置时间≥24h、存在脑脊液漏是颅内肿瘤切除术后发生颅内感染的危险因素。 相似文献
9.
目的通过分析初中生心理发展的特点,找出信件咨询常见问题的原因,提出问题解决的对策。方法通过对初中生心理咨询信件的整理分析。结果信件咨询作为学校心理咨询的一种非主流形式,由于其自身的种种缺陷并没有受到过多的重视。介从初中生的来询信件中确实反映了一些问题。结论对初中生进行心理健康教育有十分重要的意义。 相似文献
10.
慢性肾衰竭急性加重的临床特征及相关因素分析 总被引:2,自引:0,他引:2
目的:探讨慢性肾衰竭(CRF)急性加重因素及其治疗措施对预后的影响。方法:对2001年1月~2005年6月住院治疗的CRF急性加重患者42例,按其加重原因、基础疾病、治疗方式和疗效进行回顾性总结。结果:CRF急性加重因素依次为各种感染(45.2%)、原发病加重(19.0%)、高血压未控制(14.3%)、水电解质紊乱(11.9%)、肾毒性药物(11.9%)、心功能不全(9.5%)、尿路梗阻(4.8%)、血高粘滞状态(2.4%),7例同时存在≥2种上述病因(16.7%)。CRF急性加重原发病以慢性肾小球肾炎(52.4%)和糖尿病肾病(11.9%)为主。积极治疗后肾功能恢复达到或接近原来水平者40例,死亡2例,死亡2例的年龄均在60岁以上。结论:对于CRF肾功能急剧恶化的患者,应积极寻找其加重因素,并采取非透析和透析相结合治疗,改善肾功能,降低病死率,延长患者生命。 相似文献