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目的进一步研究家族性肠型胃癌的临床特征。方法随访2个家族性肠型胃癌家族,对肿瘤患者特点和家族遗传特征进行分析。结果2家系中共发现7例胃癌患者,年龄43~72岁(中位年龄65岁)。并在2个家系中各发现1例胃癌之外的肿瘤患者(1例食管癌、1例升结肠癌)。结论2个家族均符合常染色体显性遗传特征;家族中除发生胃癌外还发生其他器官肿瘤。 相似文献
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Tourette syndrome and HLA 总被引:1,自引:0,他引:1
E D Caine L R Weitkamp P Chiverton S Guttormsen R Yagnow S Hempfling D Kennelly 《Journal of the neurological sciences》1985,69(3):201-206
Five kindreds with multiple individuals manifesting Tourette syndrome (TS) or related abnormal movements were evaluated for linkage between TS and HLA-A, B, C and DR antigens. Families were selected to have a constellation of affected individuals which gave the appearance of transmission of a major susceptibility gene. All kindreds had at least two clearly affected first or second degree relatives. Although developmental neurobehavioral disorders are candidates for showing a relationship to specific tissue antigens, we found no evidence for a close linkage between a gene locus determining susceptibility to TS and the HLA loci. 相似文献
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目的 调查幽门螺杆菌(Hp)感染与上消化道癌危险性的关系。方法 在江苏省淮安市和邳州市,应用HpIgG定量酶联免疫(ELISA)检测试剂盒,随机检测312例上消化道癌及其健康一级亲属对照人群外周血中抗HpIgG。结果 ①胃癌患者中HpIgG抗体水平(阳性率50.0%)高于贲门癌患者和食管癌患者(P>0.05,χ2检验);贲门癌患者与食管癌患者之间,以上三类癌症病例与其自身亲属对照之间,差异亦不明显;②胃癌组病例与亲属同时感染Hp的阳性率(27.1%)显著高于贲门癌组和食管癌组(P<0.05),后两组之间无明显差异。结论 Hp感染在胃癌家族中存在明显家庭聚集现象,Hp感染与胃癌危险性的关系有待进一步观察。 相似文献
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