首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   64243篇
  免费   4023篇
  国内免费   541篇
耳鼻咽喉   379篇
儿科学   1436篇
妇产科学   900篇
基础医学   4157篇
口腔科学   1129篇
临床医学   11969篇
内科学   6815篇
皮肤病学   458篇
神经病学   2901篇
特种医学   1763篇
外科学   4128篇
综合类   7970篇
一般理论   10篇
预防医学   18507篇
眼科学   424篇
药学   3221篇
  302篇
中国医学   1385篇
肿瘤学   953篇
  2023年   1390篇
  2022年   2284篇
  2021年   3135篇
  2020年   3431篇
  2019年   3667篇
  2018年   3249篇
  2017年   2680篇
  2016年   1910篇
  2015年   2140篇
  2014年   5007篇
  2013年   5190篇
  2012年   4164篇
  2011年   4345篇
  2010年   3423篇
  2009年   3118篇
  2008年   2996篇
  2007年   2766篇
  2006年   2207篇
  2005年   1571篇
  2004年   1256篇
  2003年   1013篇
  2002年   842篇
  2001年   720篇
  2000年   606篇
  1999年   462篇
  1998年   381篇
  1997年   320篇
  1996年   227篇
  1995年   219篇
  1994年   175篇
  1993年   172篇
  1992年   175篇
  1991年   109篇
  1990年   86篇
  1989年   71篇
  1988年   72篇
  1987年   63篇
  1985年   281篇
  1984年   417篇
  1983年   325篇
  1982年   334篇
  1981年   326篇
  1980年   263篇
  1979年   247篇
  1978年   221篇
  1977年   167篇
  1976年   145篇
  1975年   130篇
  1974年   105篇
  1973年   81篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
目的 探讨主动呼吸循环技术(ACBT)联合肺康复运动训练对慢性阻塞性肺疾病(COPD)康复期患者心率变异性(HRV)和肺功能的影响。方法 分析2017年8月~2019年8月到我院就诊的COPD康复期患者的临床资料,从采用常规肺康复训练治疗的患者中随机选取36例为常规训练组,从采用ACBT干预的患者中随机选取36例为ACBT组,从采用常规肺康复训练联合ACBT治疗的患者中随机选取36例为常规训练+ACBT组。对比3组患者干预前、干预12周后HRV指标[24 h正常RR间期标准差(SDNN)、连续5 min正常RR间期差值的均方根值(rMSSD)、正常相邻RR间期的间隔50 ms以上的百分比(PNN50)、低频(LF)以及高频(HF)]、肺功能指标[第1 s用气呼吸容积(FEV1)、用力肺活量(FVC)、呼气峰值流速(PEF)]、康复情况[6分钟步行距离(6MWD)、Borg呼吸困难评分(BS)]及生活质量(CRQ评分)的差异。结果 干预12周后,3组患者的HRV指标、肺功能指标及CRQ评分较干预前显著提高,且常规训练+ACBT组的上述指标显著高于ACBT组和常规训练组(均P<0.05);3组患者干预12周后的6MWD评分较干预前显著提高(均P<0.05),BS评分较干预前明显降低(均P<0.05),规训练+ACBT组的6MWD评分显著高于ACBT组及常规训练组,BS评分显著低于ACBT组及常规训练组(均P<0.05)。结论 ACBT联合肺康复运动训练对COPD康复期患者进行干预,可有效改善患者心率变异性,提升患者肺功能,促进康复,提升生活质量,具有较好的应用价值。  相似文献   
2.
目的 分析大连市瓦房店地区在2016—2019年公共场所公共用具卫生状况,为卫生监督管理提供依据。方法 按照国家双随机抽检要求,2016—2019年在大连市瓦房店地区内抽查公共场所共计352家,进行微生物指标监测和分析。结果 2016—2019年共抽检公共用品用具1 057份,微生物指标合格率92.62%(978/1 057),四年间合格率差异有统计学意义(χ2=7.98,P=0.046),以2018年最高,为94.61%(158/167);不同种类公共用品用具微生物指标合格率差异有统计学意义(χ2=18.55,P<0.001),其中毛巾最低,为87.34%(276/316);不同公共场所微生物指标合格率差异有统计学意义(χ2=10.42,P=0.003),以沐浴场所微生物指标合格率最低,为50.00(3/6)。结论 大连市瓦房店地区公共场所公共用品用具的卫生状况整体良好,沐浴场所以及毛巾类样品超标严重,需要加强消毒管理。  相似文献   
3.
BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction.  相似文献   
4.
BackgroundPolypharmacy is commonly related to poor drug adherence, decreased quality of life and inappropriate prescribing in eldery. Furthermore, this condition also leads to a higher utilization of health services resources, due to the increased risk of adverse drug events, length of stays in hospitals and readmissions rates after discharge.ObjectiveThis Systematic Review aimed to synthesize the current evidence that evaluates pharmaceutical services on polymedicated patients, from an economic perspective.MethodsSystematic searches were conducted in MEDLINE, SCOPUS and Cochrane Library databases to identify studies that were published until January 2021. Experimental and observational studies were included in this review, using strict inclusion/exclusion criteria and were assessed for quality using the following tools: RoB and ROBINS-I. Two independent reviewers selected the articles and extracted the data.Results3,662 articles were retrieved from the databases. After the screening, 18 studies were included: 9 experimental and 9 observational studies. The studies reported that the integration of the pharmacist as a member of the healthcare team provides an optimized use of pharmacotherapy to polymedicated patients and contributes to health promotion, providing reduction of spending on medication, reduction of expenses related to emergency care and hospitalizations and other medical expenses. The ECRs made cost-effectiveness or cost-benefit analysis, and most of the Non Randomized studies had statistically significant cost savings even considering the expenses of pharmaceutical assistance. Experimental studies reported a cost reduction varying between US$ 193 to US$ 4,966 per patient per year. Furthermore, observational studies estimated a cost reduction of varying from US$ 3 to US$ 2,505 per patient per year. The cost savings are related to decrease in emergency visits and hospitalizations, through pharmacist intervention (medication review and pharmacotherapy follow-up).ConclusionsConsidering the set of studies included, pharmaceutical care services directed to polymedicated patients may cooperate to save financial resources. Most of the interventions showed positive economic trends and also contributed to improving clinical parameters and quality of life. However, due to the majority of the studies having exploratory or qualitative methodology, it is essential to carry out more robust studies, based on full economic evaluation.  相似文献   
5.
目的探讨对老年类风湿性关节炎(RA)应用辅助任务导向训练的干预对其手功能康复以及生存质量的影响。方法选取佛山市第五人民医院治疗的老年RA患者80例,根据入院先后顺序,通过随机数字表分为治疗组40例与对照组40例,入组患者均给予规范抗风湿药物常规治疗,对照组采取常规手部抗阻训练方式,治疗组则在对照组的基础上给予辅助任务导向训练干预,对两组干预1个月,比较干预前后两组患者手指总主动活动度(TAM)、握力、改良Barthel指数评分以及生活质量评价量表(SF-36)评分情况。结果①两组患者治疗前双侧手指TAM、握力、改良Barthel指数评分以及SF-36评分比较差异无统计学意义(P>0.05)。②治疗后,两组双侧手指TAM、握力、改良Barthel指数评分以及SF-36评分分别较组内治疗前明显改善(P<0.05)。治疗后治疗组左手TAM(268.25±20.62)°与右手TAM(259.93±23.44)°分别高于对照组左手TAM(235.56±25.21)°与右手TAM(224.37±21.86)°(P<0.05);治疗后治疗组左手握力(75.12±8.09)mmHg(1 mmHg=0.133 kPa)与右手握力(79.62±7.86)mmHg分别高于对照组左手握力(62.56±7.78)mmHg与右手握力(65.13±8.10)mmHg(P<0.05);治疗后治疗组改良Barthel指数评分(35.25±4.60)分高于对照组改良Barthel指数评分(31.56±5.25)分(P<0.05);治疗后治疗组SF-36评分(88.25±11.62)分高于对照组SF-36评分(80.56±16.21)分(P<0.05)。结论对老年RA进行辅助任务导向训练干预可提高患者手部关节活动度,增强手部握力,提高日常生活手功能活动能力以及改善生存质量水平。  相似文献   
6.
目的探讨基于量化评估下的早期循序渐进康复训练对ICU机械通气患者预后的影响。方法选取2019年1月-2020年12月ICU机械通气患者96例,将2019年1月-12月48例患者设为对照组,将2020年1月-12月48例患者设为观察组。对照组行ICU常规护理,观察组在对照组的基础上实施基于量化评估下的早期循序渐进康复训练。比较两组干预前、干预后1个月神经肌肉功能、肌力、并发症发生及预后情况。结果观察组干预后神经肌肉功能总分及各维度评分、肌力评分显著高于对照组(P<0.05)。观察组机械通气时间、入住ICU时间、总住院时间显著短于对照组(P<0.05),观察组ICU获得性肌无力、呼吸机相关性肺炎、压疮发生率显著低于对照组(P<0.05)。结论基于量化评估下的早期循序渐进康复训练能有效改善机械通气患者神经肌肉功能,降低ICU获得性肌无力、呼吸机相关性肺炎及压疮发生率,有利于患者预后及康复。  相似文献   
7.
探索重大突发公共卫生事件中以亚定点医院为代表的医疗管理模式。从上海新国际博览中心W1亚定点医院的实际运行情况出发,对其医疗供需、收治标准、运行效果、存在问题等逐一分析,结合本医疗队的经验,提出新的工作模式和管理思路。亚定点医院为普通型和有基础疾病的新冠病毒阳性感染者提供及时有效的救治,缓解了定点医院的运行压力,但也暴露出人员配置、信息化支撑、院感防控等方面的问题。采取“两级缓冲、双向转诊”的工作模式和“三个快、三个准、三个稳、三个全”的管理方案,可为患者提供及时、有效、适宜的医疗服务,缓解定点医院运行压力。  相似文献   
8.
Since its creation, the Psychiatric Guidance and Reception Centre (CPOA) has received and cared for patients aged 16 to 18. Among them, the rate of Unaccompanied Minor Refugees (UMR) has steadily increased, from 10% in 2016 to 12% in 2018. Meeting UMR patients most often occurs at the peak of their crisis, when their personal resources are overwhelmed and when they experience a severe state of psychological suffering. Our objective was to understand who UMR are concerning the particularities and the similarities they could share at clinical and therapeutic levels with other adolescents. We conducted a retrospective and observational cohort study of the 52 UMR received at the CPOA in 2018 in order to draw a portrait of them, to identify the specificities of their care, their guidance and their access to care, and to compare them with other young non UMR patients. UMR we met at CPOA in 2018 were most often boys aged 16 to 17, with limited resources and in great psychological distress. UMR had more suicidal behaviors (19%) than other minor patients (13%), and our results showed more prolonged consultations for UMR than non UMR at the CPOA (44% versus 41%), indicating that the isolated situation of UMRs complicates their ambulatory support. This study also allowed us to question the existence of emergency care specially dedicated to UMR. Although there are few recommendations to date, it seems important to reintroduce time into their care, in order to recreate a unit, which has sufficient place and time for these young patients whose lives are marked by many breakdowns.  相似文献   
9.
Backgroundand purpose: Exercise has not typically been used as an adjunct in treatment of anorexia nervosa (AN). This study aimed to examine the effects of progressive resistance exercise (PREx) on perceived quality of life (QoL) and body composition in adolescents with AN.Materials and methodsForty-four adolescents diagnosed with AN were randomly allocated to either PREx or control groups after hospitalization. The PREx group completed twenty-four PREx sessions over two months including three sets of 8–10 repetitions of eight whole-body exercises at a moderate intensity. QoL and body composition were evaluated at baseline and after two months using Health Questionnaire Short-Form 36 (SF-36) and anthropometric measurements.ResultsAt completion, forty-one participants (n = 19 PREx, and n = 22 controls) with mean age of 12.78 ± 0.88 years and mean body mass index of 18 ± 2.2 kg/m2 were analyzed. Significant group x time effects were found on SF-36 role physical (RP) scores. Significant improvements with large effect sizes (d > 0.72) were found in RP, and arm circumferences in the PREx group. Spearman association analyses between percent change in anthropometric variables and change in QoL scores showed positive associations with moderate-to-large effect sizes in the PREx group among the following variables: mid-thigh-circumference, physical functioning (PF) and general health (GH); calf-circumference relaxed and body pain; biceps skinfold and GH scores; triceps-skinfold, and role physical (RP) and vitality (VT); supraspinale-skinfold and RP and VT; mid-thigh-skinfold and calf-skinfold and VT.ConclusionPREx after hospitalization enables modest positive changes in QoL associated to anthropometric changes in adolescents with AN without adverse effects on weight recovery.  相似文献   
10.
目的:探讨有氧运动结合呼吸训练指导对慢性阻塞性肺疾病(COPD)合并衰弱患者肺功能和生命质量的影响。方法:选取2019年2月至2020年12月福建医科大学附属第一医院收治的COPD合并衰弱患者61例为研究对象,采用奇偶数字法将其分为对照组和观察组,对照组30例,每天给予常规健康教育,观察组31例,给予有氧运动结合呼吸训练指导。比较采用不同方式干预后2组患者的肺功能、睡眠质量。结果:干预后,观察组的用力肺活量占预计值的百分比(FVC%)、第1秒用力呼气量占用力肺活量的百分比(FEV1/FVC%)、第1秒用力呼气容积占预计值的百分比(FEV1%)均高于对照组(P<0.05);观察组的睡眠质量低于对照组(P<0.05)。结论:有氧运动结合呼吸训练能够改善COPD合并衰弱患者的肺功能,提高其睡眠质量。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号