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Relationship of glycated hemoglobin,and fasting and postprandial hyperglycemia in type 2 diabetes mellitus patients in Malaysia 
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Kazunori Sakurai Yuko Kawai Masanori Yamazaki Mitsuhisa Komatsu 《Journal of diabetes and its complications》2018,32(12):1118-1123
Aims
Continuous glucose monitoring (CGM) is not available for all patients with type 2 diabetes (T2D) at risk of nocturnal hypoglycemia (NH). This study was performed to predict the lowest nocturnal blood glucose (LNBG) levels.Methods
An LNBG prediction formula was developed by multivariate analysis using the data including self-monitoring of blood glucose from a formula making (FM) group of 29 insulin-treated T2D patients with CGM. The validity of the formula was assessed by nonparametric regression analysis of actual and predicted values in a formula validation group consisting of 21 other insulin-treated patients. The clinical impact on prediction was evaluated using a Parkes error grid.Results
In the FM group with a median age of 64.0, the following formula was established: Predicted LNBG (mg/dL)?=?127.4–0.836?×?Age (y)?+?0.119?×?Self-monitored fasting blood glucose (mg/dL)?+?0.717?×?Basal insulin dose (U/day) (standard error of calibration 17.2?mg/dL). Based on the validation results, standard error of prediction was 31.0?mg/dL. All predicted values fell within zones A (no effect on clinical action) and B (little or no effect on clinical outcome) on the grid.Conclusions
LNBG could be predicted, and may be helpful for NH prevention. 相似文献3.
Takahiro Yajima Kumiko Yajima Makoto Hayashi Hiroshi Takahashi Keigo Yasuda 《Journal of diabetes and its complications》2018,32(3):310-315
Aims
To evaluate the efficacy and safety of adding once-weekly dulaglutide to insulin therapy in type 2 diabetes mellitus (T2DM) patients on hemodialysis.Methods
Fifteen insulin-treated T2DM patients on hemodialysis were enrolled. Continuous glucose monitoring was performed before (1st hospitalization) and after the fifth dulaglutide administration (2nd hospitalization). The insulin dose was reduced after the first administration of dulaglutide (1st hospitalization day 6). Parameters of glycemic control were compared on 1st hospitalization days 4–5, 2nd hospitalization days 3–4, and days 6–7.Results
The median total daily insulin dose was reduced significantly from 12 (12–25) to 0 (0?12) U (p?<?0.0001) after treatment with dulaglutide. Mean glucose level on 2nd hospitalization days 3–4 significantly decreased and that on days 6–7 tended to decrease compared with that on 1st hospitalization days 4–5 (median, 8.2 to 6.7?mmol/L, P?=?0.006 and 8.2 to 6.9?mmol/L, P?=?0.053, respectively). %CV of glucose levels decreased significantly after dulaglutide administration (28.1 to 19.8, P?=?0.003 and 28.1 to 21.0, P?=?0.019). However, the incidence of hypoglycemia remained unchanged.Conclusions
Dulaglutide may improve glycemic control and excursion and allow total daily insulin to be reduced without increasing the risk of hypoglycemia in T2DM patients on hemodialysis. 相似文献4.
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背景 目标范围内时间（TIR）作为血糖管理的新指标，与短期血糖波动相关，是否与长期血糖变异性相关尚不清楚。 目的 探讨老年男性2型糖尿病患者TIR与长期随访期间糖化血红蛋白（HbA1c）变异系数、HbA1c变异性评分（HVS）的关系。 方法 选取2007年1月至2011年1月在解放军总医院第二医学中心住院行动态血糖监测（CGM）的老年男性2型糖尿病患者200例，根据患者基线TIR水平，将其分为TIR≥85%组（n=141）和TIR<85%组（n=59）。对受试者随访观察（12.5±1.1）年，比较两组长期随访期间HbA1c变异系数和HVS。采用Pearson相关、多元线性回归分析TIR与HbA1c变异系数、HVS的关系。 结果 TIR<85%组患者的长期HbA1c变异系数〔（9.7±3.8）%比（8.2±4.5）%，P=0.028）〕、HVS〔（48.7±20.4）分比（32.5±20.8）分，P<0.001）〕均明显高于TIR≥85%组。Pearson相关分析结果显示，TIR与长期HbA1c变异系数（r=-0.239，P<0.001）、HVS（r=-0.400，P<0.001）呈线性负相关。多元线性回归分析结果显示，在调整混杂因素后，TIR对长期HbA1c变异系数、HVS有影响〔b（95%CI）分别为-0.07（-0.12，-0.03）、-0.44（-0.67，-0.21），P<0.05〕。 结论 老年男性2型糖尿病患者TIR与长期随访期间HbA1c变异系数、HVS相关。TIR越低的患者，长期血糖变异性越明显。 相似文献
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