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1.
孟繁英 《吉林医药学院学报》2018,(4):274-275
医学高校要培养医学"全人",必须强调了各门课程的协同作用,重视职业技能与职业精神的融合,本文探寻医学生职业技能与职业精神融合的路径,以期对全方位推进医学高校的思想政治工作有所帮助. 相似文献
2.
目的探讨慢性乙型肝炎患者血清HBV DNA含量对IL-12诱导其PBMC产生Th1/Th2类细胞因子协同效应的影响。方法选取2017年1月至2018年6月我院收治的慢性乙型肝炎患者120例,对所有患者的血清乙肝病毒的脱氧核糖核酸(HBV DNA)含量进行测量,对不同血清HBV DNA含量的患者外周血单个核细胞(PBMC)产生Th1/Th2类细胞因子含量进行测量。结果 HBV DNA含量10~3拷贝/mL的患者21例,在10~3~10~5拷贝/mL之间的患者37例,在10~5~10~7拷贝/mL之间的患者32例,10~7拷贝/mL的患者30例;随着HBV DNA含量升高,抗原单独诱导或者是与IL-12一同诱导,PBMC产生Th1类细胞因子IL-2(白细胞介素-2)、IFN-γ(γ-干扰素)的含量不断下降,而Th2类细胞因子IL-4(白细胞介素-4)、IL-10(白细胞介素-10)的含量不断增高。抗原单独诱导与联合IL-12一同诱导相比较,随着HBV DNA含量升高,IL-12对PBMC产生的IFN-γ细胞因子协同效应不断下降,尤其对于10~7拷贝/mL的患者基本无协同效应。对于10~3拷贝/mL的患者,IL-12对HbeAg(e抗原)诱导PBMC产生的IL-4细胞因子有显著的抑制作用、在10~3~10~5拷贝/mL之间的患者,对IL-4细胞因子、IL-10细胞因子有显著的抑制作用;e抗原阴性患者PBMC产生的IFN-γ、IL-4细胞因子高于e抗原阳性患者(P0.05);e抗原阴性患者PBMC产生的IL-10细胞因子含量低于e抗原阳性患者(P0.05)。结论慢性乙型肝炎患者血清HBV DNA含量对IL-12诱导其PBMC产生Th1/Th2类细胞因子协同效应的研究期间,血清HBV DNA含量越高对IL-12诱导其PBMC产生IFN-γ细胞因子协同效应存在明显的抑制。 相似文献
3.
Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production 总被引:1,自引:0,他引:1
Carvalho AT Souza H Carneiro AJ Castelo-Branco M Madi K Schanaider A Silv F Pereira Junior FA Pereira MG Tortori C Dines I Carvalho J Rocha E Elia C 《World journal of gastroenterology : WJG》2007,13(15):2166-2173
AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor α (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD).
METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-α and IL-12 were quantified in the supernatant of organ cultures by ELISA.
RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-α and IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-α levels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-α and IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells.
CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. 相似文献
METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-α and IL-12 were quantified in the supernatant of organ cultures by ELISA.
RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-α and IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-α levels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-α and IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells.
CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. 相似文献
4.
目的 针对社区中喝酒抽烟人群开展健康教育,减少疾病隐患,提高保健意识。方法采取多种教育方式,由社区护士向抽烟喝酒人群传授知识,使其逐步戒除不良嗜好,培养良好的生活方式。结果通过健康教育,达到了预期目的。结论健康教育是一项低投入、高产出、高效益的保健措施,值得存社区中推广使用。 相似文献
5.
6.
枸杞子多糖及合并应用厌氧短棒杆菌菌苗对小鼠腹腔巨噬细胞抑制肿瘤增殖活性 总被引:6,自引:0,他引:6
本研究观察了中药枸杞子(Lycium barbarumL.)提取物枸杞多糖(LBP)对小鼠腹腔巨噬细胞抑制肿瘤增殖活性的影响。结果表明,给正常小鼠ipLBP40mg/kg×7d能增强经ConA处理的巨噬细胞抑制肿瘤靶细胞增殖的活性;LBP5,10,20,40mg/kg×7d并与小剂量(250ug/只)厌氧短棒杆菌菌苗(Corynebacterium parvum,CP)合并应用,具有明显的协同效应,在LBP浓度为20mg/kg时,效应最为显著,对靶细胞P815及P388增殖的抑制率分别为85.5%和63.3%;CP对照组则为28.1%及240%,表明合并应用LBP及CP可减少二者的用量,增强效应,减低CP的毒副作用,据本室先前的研究发现,LBP为主要作用于T细胞的免疫增强剂,能增强CTL,NK细胞的功能;CP则为巨噬细胞刺激剂,本研究结果提示,合并应用作用于免疫应答不同环节的免疫增强剂可获得协同效主尖,这将为临床肿瘤的免疫疗法中免疫增强剂的联合应用提供参考,此外,本实验还发现,来自经肿瘤细胞免疫小鼠的腹腔巨噬细胞,表现出较强的特异性抑制肿瘤增殖活性,LBP则能进一步加强其作用。以上结果提示,LBP无论对巨噬细胞在非特异性抗肿瘤或特异性抗肿瘤过程中,均具有激活作用。 相似文献
7.
《国外医药(抗生素分册)》2009,30(2):93-93
传统上,进行长期抗生素治疗已经成为慢性细菌性前列腺炎(CBP)治疗的金标准。然而,由于这种治疗方法的治疗效果不够理想及长期抗生素用药易导致不良反应和细菌耐药等因素,患者和医生对慢性细菌性前列腺炎的这种治疗方法均不满意,而较关注植物药疗法和其他替代疗法。番茄红素是番茄提取物,报道其通过抗氧化功效而具有抗炎作用。 相似文献
8.
目的 针对社区中喝酒抽烟人群开展健康教育,减少疾病隐患,提高保健意识.方法 采取多种教育方式,由社区护士向抽烟喝酒人群传授知识,使其逐步戒除不良嗜好,培养良好的生活方式.结果 通过健康教育,达到了预期目的 .结论 健康教育是一项低投入、高产出、高效益的保健措施,值得在社区中推广使用. 相似文献
9.
血管紧张素原M235T基因多态性及体重指数与原发性高血压的关系 总被引:1,自引:0,他引:1
目的探讨血管紧张素原(ATG)基因多态性及体重指数与高血压的关系。方法采用聚合酶链反应结合限制性内切酶消化,对72例原发性高血压患者和78例血压正常者血管紧张素原的M235T基因多态性进行检测。结果高血压组收缩压、体重指数和血管紧张素原水平均高于正常对照组(P〈0.05);高血压组与对照组的MM、MT和TT基因型频率分别为0.347、0.319、0.333,0.564、0.244、0.192,差异明显(P〈0.05),TT基因型患高血压的相对危险最高。调整多种混杂因素后,Logistic回归分析示T等位基因和体重指数均不同程度的增加了高血压患病的危险性,同时二者存在着协同作用。结论T等位基因、体重指数是预测高血压危险性的有效指标,且二者存在协同效应。控制体重可以有效地防治高血压。 相似文献
10.
[目的]探讨协同效应在治疗老年慢性阻塞性肺疾病(COPD)并发呼吸衰竭病人治疗中的应用及护理效果.[方法]对26例老年COPD并发呼吸衰竭病人实施协同治疗(无创通气联合舒利迭吸入)、有效的呼吸道管理、心理护理及健康教育、严密细致的病情观察,同时对并发症先兆症状给予恰当的处理及护理.[结果]协同治疗7 d后,病人呼吸频率、心率、呼吸困难、发绀、血气指标等临床症状明显改善.[结论]协同效应是治疗老年COPD 并发呼吸衰竭的一种有效措施,而正确使用呼吸机和舒利迭、保持呼吸道通畅及防治并发症是护理工作的重点. 相似文献