下生殖道感染与子宫颈细胞学异常的相关性研究

Objective?To study the association between abnormal cervical cytology and bacterial vaginosis (BV), vulvovaginal candidiasis(VVC), trichomonas vaginitis(TV), high-risk human papillomavirus(HR-HPV) infection in women attending cervical cancer screening. Methods?The study recruited 3 300 women aged 21 to 64 years of age who participated in cervical cancer screening. Demographic information was collected. Cervical exfoliated cell specimens were collected for liquid-based cytological diagnosis and HR-HPV detection. Reproductive tract secretions specimens were collected for molecular vaginitis diagnostics from women who were diagnosed with negative for intraepithelial lesion or malignancy(NILM) and all HR-HPV positive or ≥atypical squamous cells of undetermined significance(ASC-US). The Logistic multivariate model was used to analyze the risk factors of abnormal cervical cytology. Results?645 women were included in the study, including 408 NILM, 182 ASC-US, 23 low-grade squamous intraepithelial lesion (LSIL), and 32 high-grade squamous intraepithelial lesions (HSIL). The positive rate of HR-HPV (14.7%, 39.0%, 78.3% and 87.5%) increased with the severity of cytology (P<0.001). The prevalence of BV in different cytological diagnosis (34.1%, 49.5%, 60.9% and 43.8%) were significantly different (P<0.001), and the prevalence of BV in ASC-US were significantly higher than that in women with NILM (P<0.05). The prevalence of VVC in different cytological diagnosis (14.2%, 4.9%, 8.7% and 3.1%) was significantly different (P<0.01), and the ASC-US group was significantly lower than the NILM group (P<0.001). There was also a significant difference in the distribution of the prevalence of TV (2.5%, 9.3%, 4.3%, and 6.3%, P<0.01). The prevalence of TV in women with abnormal cytology was higher than that in women with normal cytology(P<0.05). The Logistic analysis showed that HR-HPV infection, BV, TV, VVC, lower level of education, and postmenopause were related to abnormal cervical cytology. Conclusion?HR-HPV infection is the determinant of abnormal cervical cytology. BV, TV, VVC, lower level of education, postmenopause, etc. may associate with abnormal cervical cytology.     

利用山羊红细胞进行人外周血E玫瑰花测定的初步报告

目前国内外应用E玫瑰花结反应测定人外周血T淋巴细胞水平的方法,都是采用绵羊血。1976年我们在四川省盐亭县食管癌现场工作过程中,遇到因当地不适绵羊生存,只有山羊的问题。为了适应工作需     

术前放疗对中晚期食管癌的疗效观察

目的:对采用钴60进行术前放疗的疗效进行分析。方法:根据治疗方式的不同,将治疗的73例中晚期食管癌患者划分为术前放疗组和非放疗组,并对其治疗总有效率和术后3、5年生存率进行观察和分析。结果:术前放疗组患者的总有效率为68.84%,非放疗组患者的总有效率为45.87%。术后3、5年的生存率分别为43.46%和22.44%、35.21%和18.19%。结论:术前放疗能够有效提高食管癌患者的临床缓解率以及术后3、5年的生存率,但由于其容易引发患者的呼吸功能不全,并且会提高患者的住院死亡率,因此在应用时应加以注意。     

盐亭县核黄素强化盐干预试验人群食管癌前病变与转归的研究

目的:研究核黄素强化盐对食管癌高发人群食管癌前状态的影响.方法:用食管脱落细胞学检查方法,比较分析在食管癌高发区四川盐亭县开展核黄素强化营养盐干预5年的前后,试验组与对照组食管上皮增生的检出率、食管正常者的进展率和食管增生者的逆转率,评价核黄素强化盐对人群的食管癌前病变的干预效果.结果:干预试验前,试验组和对照组的食管上皮增生检出率,男性分别为19.6%(47/240)和10.9%(24/222),女性分别为15.5%(36/233)和13.6%(29/213);干预5年后,试验组男性和女性食管上皮增生检出率分别为12.5%(30/240)和12.9%(30/233),比对照组分别降低49/6%(X2=11.55,P<0.01)和57.0%(X219.68,P<0.01).与对照相比,试验组男性和女性食管增生转归的比数比分别为3.8(95%CI为1.1～13.2,P<0.05)和10.0(95%CI为2.6～37.9,P<0.01);而在正常人群中,试验组男性和女性食管向癌变进展的比数比分别为0.42(95%CI为0.24～0.76,P<0.01)和0.38(95%CI为0.21～0.68,P<0.01).结论:在食管癌高发区人群中实施核黄素强化营养盐的干预措施能延缓和逆转食管癌前病变的发展进程,有益于降低食管癌的发病率.     

食管癌围术期心律失常的处理

目的了解食管癌患者围术期发生心律失常的特点及处理要点。方法总结了1995年-2005年1872例食管癌患者围术期发生心律失常的764例,发生率为40.81%,并按每10岁分组(不含39岁以下者)进行了比较,分析其相关因素及治疗措施。结果1872例食管癌患者围术期发生心律失常者764例,发生率40.81%,并提示随年龄增大,心律失常明显增多。结论术前充分了解心血管功能,评估心律失常的危险性,积极有效地抗心律失常,维持血压、心率及心律的原水平是麻醉的主要目标,对于提高麻醉和手术安全性具有重要意义。     

盐亭食管癌高发区饮食喂饲大鼠血清叶酸水平及添加叶酸等维生素的影响

目的:探讨盐亭食管癌高发区饮食喂饲的大鼠血清叶酸水平及复合维生素对其影响.方法:将雄性Sprague-Dawley( SD)大鼠随机分为4组,每组10只.分别喂饲大鼠常规饲料、盐亭饮食、盐亭饮食添加维生素(维生素A、E、叶酸,设高、低两个剂量).各组大鼠喂饲30天后经股动脉取血,用微生物法测定其血清叶酸水平.结果:盐亭...     

百合固金汤加味治疗放射性肺炎114例

放射性肺炎是胸部恶性肿瘤在放疗过程中所导致的放射性肺损害并发症之一。严重影响到患者的康复和进一步治疗，目前西医药治疗尚不理想。根据中医辨证施治原则，采用百合固金汤加味治疗放射性肺炎114例，结果治愈49例，显效52例，无效13例，总有效率89％。证明百合固金汤加味治疗放射性肺炎疗效确切，供同道参考。     

食管上皮细胞重度增生患者417例配对分析

本文通过４１７例食管上皮细胞重度增生（以下简称重度增生）研究说明：重度增生的检出率以４０～４９岁组为多，占３５．０％。重度增生与食管正常配对分析说明重度增生患者的咽喉部不适紧缩感、咽下食物梗噎感和胸骨后不适疼痛感出现率均明显高于食管正常居民（Ｐ＜０．０１），而冒酸和剑突下疼痛出现率差异不显著（Ｐ＞０．０５）。     

46161例食管上皮正常、增生癌变时间、癌变率的研究

 对食管上皮细胞正常（以下简称正常）、食管上皮细胞轻度增生（以下简称轻度增生）和食管上皮细胞重度增生（以下简称重度增生）共46161例进行了癌变时间和癌变率的研究结果说明：食管癌变平均时间的频率差异为重度增生癌变平均时间3年7月＜轻度增生癌变平均时间5年4月＜食管正常癌变平均时间8年10月。食管癌变率的频率差异为重度增生癌变率38．9%＞轻度增生癌变率5．8%＞正常癌变率1．4%。