新疆宫颈癌高发区维吾尔族人群人乳头瘤病毒亚型的研究

目的 分析人乳头瘤病毒(HPV)各亚型在新疆宫颈癌高发区维吾尔族人群中的分布.方法 通过凯普导流杂交HPV DNA检测法,对新疆墨玉县喀尔赛乡维吾尔族男性尿道分泌物及女性宫颈分泌物(各400例)进行21种HPV亚型的检测.结果 (1)女性HPV感染总阳性率为14.25%,HPV亚型按其出现的频率依次为HPV16、58、39、18、33、52、43、66、CP8304、6、11,其中HPV16在HPV阳性者中比例最高(66.67%).(2)男性HPV总阳性率为8.00%,其中HPV16在HPV阳性者中比例最高(44.44%);HPV亚型按其出现的频率依次为HPV16、43、33、39、6(39和6型并列)、53.(3)夫妻间配对后发现男、女性HPV感染类型不同;女性HPV感染者的配偶中大部分HPV阴性;而男性HPV阳性者的配偶中也大部分HPV阴性.夫妻HPV感染吻合率为7.02%,而男性HPV感染与女性吻合率为9.38%.结论 HPV在新疆维吾尔族人群中的阳性率均较低,但HPV阳性者中高危型HPV尤其是HPV16的构成比高,HPV16是新疆地区维吾尔族人群中流行的主要病毒类型.     

新疆宫颈癌高发区维吾尔族人群人乳头瘤病毒亚型的研究

目的 分析人乳头瘤病毒(HPV)各亚型在新疆宫颈癌高发区维吾尔族人群中的分布.方法 通过凯普导流杂交HPV DNA检测法,对新疆墨玉县喀尔赛乡维吾尔族男性尿道分泌物及女性宫颈分泌物(各400例)进行21种HPV亚型的检测.结果 (1)女性HPV感染总阳性率为14.25%,HPV亚型按其出现的频率依次为HPV16、58、39、18、33、52、43、66、CP8304、6、11,其中HPV16在HPV阳性者中比例最高(66.67%).(2)男性HPV总阳性率为8.00%,其中HPV16在HPV阳性者中比例最高(44.44%);HPV亚型按其出现的频率依次为HPV16、43、33、39、6(39和6型并列)、53.(3)夫妻间配对后发现男、女性HPV感染类型不同;女性HPV感染者的配偶中大部分HPV阴性;而男性HPV阳性者的配偶中也大部分HPV阴性.夫妻HPV感染吻合率为7.02%,而男性HPV感染与女性吻合率为9.38%.结论 HPV在新疆维吾尔族人群中的阳性率均较低,但HPV阳性者中高危型HPV尤其是HPV16的构成比高,HPV16是新疆地区维吾尔族人群中流行的主要病毒类型.     

新疆宫颈癌高发区维吾尔族人群人乳头瘤病毒亚型的研究

目的 分析人乳头瘤病毒(HPV)各亚型在新疆宫颈癌高发区维吾尔族人群中的分布.方法 通过凯普导流杂交HPV DNA检测法,对新疆墨玉县喀尔赛乡维吾尔族男性尿道分泌物及女性宫颈分泌物(各400例)进行21种HPV亚型的检测.结果 (1)女性HPV感染总阳性率为14.25%,HPV亚型按其出现的频率依次为HPV16、58、39、18、33、52、43、66、CP8304、6、11,其中HPV16在HPV阳性者中比例最高(66.67%).(2)男性HPV总阳性率为8.00%,其中HPV16在HPV阳性者中比例最高(44.44%);HPV亚型按其出现的频率依次为HPV16、43、33、39、6(39和6型并列)、53.(3)夫妻间配对后发现男、女性HPV感染类型不同;女性HPV感染者的配偶中大部分HPV阴性;而男性HPV阳性者的配偶中也大部分HPV阴性.夫妻HPV感染吻合率为7.02%,而男性HPV感染与女性吻合率为9.38%.结论 HPV在新疆维吾尔族人群中的阳性率均较低,但HPV阳性者中高危型HPV尤其是HPV16的构成比高,HPV16是新疆地区维吾尔族人群中流行的主要病毒类型.

Abstract：

Objective To study the distribution of human papilloma virus(HPV)subtypes in Uyghur people from the high risk region of cervical cancer in Xinjiang. Methods 21 subtypes of HPV from 400 cases of men's swabs of penile and 400 cases of women's cervix swabs were detected, using flow-through hybridization and gene chip technology. Results(1)The positive rate of HPV among the 400 women cases was 14.25% ,with HPV16 the most common type. In women whose HPV was positive, the positive rate of HPV16 was 66.67%. The ranking of frequencies on the HPV subtypes in women were: HPV 16, 58,39, 18,33,52,43,66, CP8304, HPV6 and 11.(2)Among the 400 male cases, the positive rate of HPV was 8.00%, with HPV16 the most common type. In men whose HPV was positive, the rate of HPV16 was 44.44%. The ranking of HPV subtypes in men were HPV16, 43, 33, 39, 6(HPV39 and 6 are equivalent)and 53.(3)Both wives and husbands were infected by different subtypes of HPV, the positive rate was relatively low among men whose wife's HPV were positive. However, the HPV positive rate was relatively low among women whose husband's HPV were positive. The concordance infection rate of women and men were 7.02% and the concordance infection rate of men and women were 9.38%. Conclusion The HPV positive rates were relatively low in both men and women living in the region with high risk of cervical cancer in Xinjiang. However, the positive rate of high risk types HPV and HPVI6 in both men and women were relatively high. Uyghur men seemed to have played a certain role related to the carcinogenensis of cervical cancer. HPV16 was the main type in both men and women in Xinjiang.