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1.
IntroductionAlthough hyperferritinemia may reflect the inflammatory status of patients with non-alcoholic fatty liver disease (NAFLD), approximately 33% of hyperferritinemia cases reflect real hepatic iron overload.AimTo evaluate a non-invasive method for assessing mild iron overload in patients with NAFLD using 3T magnetic resonance imaging (MRI) relaxometry, serum hepcidin, and the expression of ferritin subunits.MethodsThis cross-sectional study assessed patients with biopsy-proven NAFLD. MRI relaxometry was performed using a 3T scanner in all patients, and the results were compared with iron content determined by liver biopsy. Ferritin, hepcidin, and ferritin subunits were assessed and classified according to ferritin levels and to siderosis identified by liver biopsy.ResultsA total of 67 patients with NAFLD were included in the study. MRI revealed mild iron overload in all patients (sensitivity, 73.5%; specificity, 70%). For mild (grade 1) siderosis, the transverse relaxation rate (R2*) threshold was 58.9 s?1 and the mean value was 72.5 s?1 (SD, 33.9), while for grades 2/3 it was 88.2 s?1 (SD, 31.9) (p < 0.001). The hepcidin threshold for siderosis was > 30.2 ng/mL (sensitivity, 87%; specificity, 82%). Ferritin H and ferritin L subunits were expressed similarly in patients with NAFLD, regardless of siderosis. There were no significant differences in laboratory test results between the groups, including glucose parameters and liver function tests.ConclusionsMRI relaxometry and serum hepcidin accurately assessed mild iron overload in patients with dysmetabolic iron overload syndrome.  相似文献   
2.
Background and aims(Poly)phenols might contribute to prevent cardiovascular disease, but limited prospective studies exist among adolescents. This study aimed to evaluate within-subject longitudinal changes in (poly)phenols intakes and food group contributors while also exploring the association with metabolic syndrome risk (MetS) during 10 years of follow up in European adolescents becoming young adults.Methods and resultsIn 164 participants (58% girls, 13-18 y at baseline) from Ghent, Zaragoza and Lille, longitudinal data (2006–2016) on (poly)phenol intake was retrieved via 2 or 3 24 h recalls. Linear and logistic longitudinal regression tested the association of (poly)phenols intake (total and classes) with Mets risk or its components (waist-height-ratio, HDL cholesterol, LDL cholesterol, triglycerides, blood pressure and insulin resistance index), adjusted for age, sex, country and other nutrient intakes. The total (poly)phenols intake was 421 ± 107 mg/day (192 mg/1000 kcal/day) at baseline, while 610 ± 101 mg/day (311 mg/1000 kcal/day) at follow-up. The three major food sources for (poly)phenols were ‘chocolate’, ‘fruit and vegetable juices’, ‘cakes and biscuits’ during adolescence and ‘coffee’, ‘tea’ and ‘chocolate’ during adulthood. Phenolic acid intake was associated with less LDL increase over time, while stilbene intake with a steeper increase in triglycerides over time.ConclusionsDifferences in major (poly)phenols contributors over time were partially explained by age-specific dietary changes like increased coffee and tea during adulthood. Some significant (poly)phenols-MetS associations might argue for nutrition-based disease prevention during adolescence, especially since adolescents had low (poly)phenols intake.  相似文献   
3.
Background and aimsWhile low-density lipoprotein cholesterol (LDL-C) is a good predictor of atherosclerotic cardiovascular disease, apolipoprotein B (ApoB) is superior when the two markers are discordant. We aimed to determine the impact of adiposity, diet and inflammation upon ApoB and LDL-C discordance.Methods and resultsMachine learning (ML) and structural equation models (SEMs) were applied to the National Health and Nutrition Examination Survey to investigate cardiometabolic and dietary factors when LDL-C and ApoB are concordant/discordant. Mendelian randomisation (MR) determined whether adiposity and inflammation exposures were causal of elevated/decreased LDL-C and/or ApoB. ML showed body mass index (BMI), dietary saturated fatty acids (SFA), dietary fibre, serum C-reactive protein (CRP) and uric acid were the most strongly associated variables (R2 = 0.70) in those with low LDL-C and high ApoB. SEMs revealed that fibre (b = ?0.42, p = 0.001) and SFA (b = 0.28, p = 0.014) had a significant association with our outcome (joined effect of ApoB and LDL-C). BMI (b = 0.65, p = 0.001), fibre (b = ?0.24, p = 0.014) and SFA (b = 0.26, p = 0.032) had significant associations with CRP. MR analysis showed genetically higher body fat percentage had a significant causal effect on ApoB (Inverse variance weighted (IVW) = Beta: 0.172, p = 0.0001) but not LDL-C (IVW = Beta: 0.006, p = 0.845).ConclusionOur data show increased discordance between ApoB and LDL-C is associated with cardiometabolic, clinical and dietary abnormalities and that body fat percentage is causal of elevated ApoB.  相似文献   
4.
Weight among immigrants in the United States (US) is lower than among the US-born on average, but higher among long-term immigrants than the newly arrived. Neighborhood coethnic concentration—the proportion of neighborhood residents of the same ethnic background—may influence weight among immigrants via behavioral norms and market-driven community resources. However, the relevant exposure timeframe may be far longer than is captured by existing cross-sectional and short-term studies. Using detailed historical residential address information on 1449 older Latino and Chinese long-term immigrants, we investigated associations of 10–20-year neighborhood coethnic concentration trajectories with current waist circumference and weight-related behaviors (diet, physical activity, and sedentary time). Among Chinese participants, compared to persistent low coethnic concentration, increasing coethnic concentration was associated with higher waist circumference (difference = 1.45 cm [0.51, 2.39]). In contrast, both increasing coethnic concentration and persistent high coethnic concentration were associated with a healthier diet. Among Latino participants, trajectories characterized by higher coethnic concentration were associated with higher waist circumference (e.g., difference = 2.11 cm [0.31, 3.91] for persistent high vs. persistent low) and low physical activity. Long-term patterns of neighborhood coethnic concentration may affect weight-related outcomes among immigrants in complex ways that differ by ethnicity and outcome.  相似文献   
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6.
背景 代谢综合征(MS)与冠心病、糖尿病等慢性病密切相关,其患病率逐年升高,但目前诊断标准不统一,诊断条件复杂,基层医务人员操作困难。目的 比较中国人群中人体测量学指标〔腰高比(WHtR)、腰臀比(WHR)、腰围(WC)、体质指数(BMI)〕及三酰甘油葡萄糖乘积(TyG)指数、TyG指数与BMI的乘积(TyG-BMI)、TyG指数与WC的乘积(TyG-WC)与MS相关性的差异及其对MS的诊断价值,确定MS的简易筛查指标。方法 选取北京市通州区觅子店社区2 972例参加健康体检人员,分别进行问卷调查、体格检查及实验室检查,计算WHtR、WHR、BMI及TyG指数、TyG-BMI、TyG-WC。依据中华医学会糖尿病学分会(CDS)诊断标准确定MS患者。采用SPSS 18.0统计软件绘制上述各项指标诊断MS的受试者工作特征(ROC)曲线,计算曲线下面积(AUC),并采用MedCalc 16.8软件进行AUC比较。结果 男性和女性的MS患病率无统计学差异〔206/1 044比368/1 928,P>0.05〕。同性别MS患者的WHtR、WHR、WC、BMI、TyG指数、TyG-BMI、TyG-WC均高于非MS者(P<0.05)。BMI、WHtR、WHR、WC诊断男性MS的AUC分别为0.81、0.77、0.68、0.77,诊断女性MS的AUC分别为0.78、0.76、0.66、0.76,BMI诊断男性MS和女性MS的AUC均高于其他3项指标(P<0.05)。BMI诊断男性和女性MS的切点分别为25.00、25.30 kg/m2。TyG指数、TyG-BMI、TyG-WC诊断男性MS的AUC分别为0.88、0.89、0.88,诊断女性MS的AUC分别为0.88、0.88、0.87,TyG指数诊断男性MS和女性MS的AUC与其他2项指标比较无统计学差异(P>0.05)。TyG指数诊断男性和女性MS的切点分别为8.87、8.80。TyG指数诊断男性MS和女性MS的AUC高于BMI(P<0.05)。结论 人体测量学指标、TyG指数及其相关指数与MS均明显相关。BMI同MS的相关性优于其他人体测量学指标,可用于MS的大规模人群初步筛查;TyG指数的诊断价值优于BMI,可作为基层医务人员判断MS风险的简易指标。  相似文献   
7.
AimTo assess the association between elevated waist circumference (WC) and high waist-to-height ratio (WHtR) with insulin resistance biomarkers.MethodsWe conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC ≥ 90 in male participants and WC ≥ 80 in adult women as elevated, and values of WHtR≥0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C) ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio ≥ 3 as high and TGI values ≥ 8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI).ResultsWe analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2% (n = 61) and 33.2% (n = 118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8% (n = 88) and 12.7% (n = 45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR = 3.61; 95%CI: 1.59–8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR = 2.54; 95%CI:1.08–5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR = 1.54; 95%CI: 0.95–2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR = 1.87; 95%CI: 1.00–3.50).ConclusionElevated WC and high WHtR were associated with a high TG/HDL-C ratio in women. It is necessary to perform prospective follow-up studies in the Peruvian population in order to corroborate our results.  相似文献   
8.
BackgroundCalf circumference (CC) has been used as a surrogate for calf muscle mass, which facilitates venous blood return to the heart through active skeletal muscle. However, the correlation between CC and calf muscle mass has not been extensively examined. This study aimed to examine the relationship between CC and calf muscle mass considering differences in sex and physique in elderly individuals.MethodsA total of 124 community-dwelling elderly individuals ≥60 years of age (61 men, mean [±SD] age 74.3 ± 5.7 years) were enrolled. Maximal CC was measured using a tape measure with the subject supine. The cross-sectional area of skeletal muscle tissues was measured using magnetic resonance imaging from the point of greatest calf circumference to 5 cm proximal and distal. Calf muscle mass was calculated by multiplying the area of each slice by slice thickness (5 mm).ResultsCC was strongly correlated with calf muscle mass in male and female subjects (male: r = 0.908, P < 0.001; female: r = 0.892, P < 0.001). Multiple regression analysis revealed that CC and body mass index (BMI) were independent associate factors of calf muscle mass. The following estimation formulae were derived: (male) calf muscle mass (cm3) = 47.82 × CC (cm)−12.50 × BMI (kg/m2) −732.80; (female) calf muscle mass (cm3) = 32.23 × CC (cm) −4.85 × BMI (kg/m2) −429.94.ConclusionsA strong correlation was found between CC and calf muscle mass according to magnetic resonance imaging. Sex differences and BMI should be considered for accurate estimation of calf muscle mass using CC.  相似文献   
9.
目的 了解四川省西昌市居民的中心性肥胖流行现况与影响因素,为后续当地相关的干预措施的制定提供理论依据与数据支持。方法 综合考虑经济水平、民族构成、地理位置等因素,在西昌市选择6个调查点,根据调查点社区人口数确定抽样比例,采用简单随机抽样的方法抽取18周岁及以上的成年居民进行问卷调查与体格检查,对所得数据进行描述性分析、单因素χ2分析与多因素logistic回归分析。结果 共纳入874名居民,中心性肥胖率为39.24%。单因素分析结果显示,不同饮酒情况(χ2=4.914,P<0.05)、高血压患病情况(χ2=15.869,P<0.001)、BMI(χ2=300.521,P<0.001)的成年居民中心性肥胖率不同。多因素分析结果显示,饮酒者(OR=1.545,95%CI:1.028~2.322)、高血压患者(OR=1.684,95%CI:1.093~2.592)发生中心性肥胖的风险所增加;相较于正常体重(18.5kg/m2≤BMI<23.9kg/m2)的居民,BMI<18.5kg/m2组别人群(OR=0.114,95%CI:0.015~0.843)发生中心性肥胖的风险更低,而BMI≥24.0kg/m2组别人群(OR=12.196,95%CI:8.630~17.234)则风险更高。 结论 西昌市成年居民中心性肥胖率较低。BMI<18.5kg/m2为中心性肥胖的保护因素,而饮酒、高血压患病、BMI≥24.0kg/m2为中心性肥胖的危险因素。  相似文献   
10.
目的:分析东乡族成人围度特点及其与血压间的关系。方法:采用随机整群抽样法选取甘肃临夏州东乡县 东乡族成年居民1 160 名,测量研究对象血压及颈围、胸围、腰围、腹围、臀围、大腿围、小腿围及上臂围等指 标,并分析收缩压、舒张压与围度的关系。 结果:东乡族男性及女性不同年龄段各围度指标差异均有统计学意义; 东乡族成人高血压检出率为27.41%,其中男性、女性分别为29.05%、26.47% ;多元线性回归分析显示,性别、 年龄、颈围、腰围是东乡族成人收缩压的影响因素,舒张压与年龄、颈围及上臂围呈正相关。结论:东乡族成人 高血压患病率略高于全国城市平均水平,但低于全国农村水平;颈围、腰围及上臂围均可作为预测血压的围度指标。  相似文献   
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